Navigation Links
A novel target for therapeutics against Staph infection
Date:11/27/2008

Researchers at the Texas A&M Health Science Center Institute of Biosciences and Technology, and the University of Edinburgh have uncovered how a bacterial pathogen interacts with the blood coagulation protein fibrinogen to cause methicillin-resistant Staphylococcus aureus (MRSA) infections, a finding that could aid in developing therapeutics against the potentially deadly disease. Their work appears November 28 in the open-access journal PLoS Pathogens.

Once occurring more commonly in healthcare facilities, but now affecting segments of the general population, MRSA is a bacterial pathogen responsible for a range of diseases from mild skin infection to life-threatening sepsis. Even with antibiotics, these infections can still be fatal.

Senior author Magnus Hk, Ph.D. and his colleagues carried out biochemical and structural studies to determine the binding mechanism of clumping factor A (ClfA), a surface protein that plays an important role in the pathogenesis of S. aureus. The group found that ClfA binds to the blood-clotting protein fibrinogen (Fg) at a site that is also responsible for inducing platelet activation and thrombosis (clot inside a blood vessel).

The results show significant structural differences in how staphylococcal and platelet receptor proteins recognize fibrinogen. By exploiting this difference in recognition, the researchers show that agents could be designed that inhibit the ClfAFg interaction but do not interfere with the interaction of Fg with the platelet integrin, therefore avoiding unwanted side effects on the circulatory system.


'/>"/>

Contact: Mary Kohut
Press@plos.org
415-568-3457
Public Library of Science
Source:Eurekalert

1

GOOD

Page: 1

Related biology news :

1. Corn researchers discover novel gene shut-off mechanisms
2. 3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions
3. UT Southwestern researcher awarded Gates Foundation grant for novel vaccine development
4. GEN reports on novel tools for deciphering biological networks
5. Novel publishing approach puts textbook in more hands
6. Cold Spring Harbor Laboratory scientists trace a novel way cells are disrupted in cancer
7. Childrens National researchers develop novel anti-tumor vaccine
8. LIAI launches new division to look at novel approaches to heart disease and inflammation
9. Conaway Lab identifies novel mechanism for regulation of gene expression
10. Scientists identify novel inhibitor of human microRNA
11. Using novel tool, UD researchers dig through cell trash and find treasure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/5/2009)..., A team of researchers at Princeton University an...d a long-sought gene that is fatefully switched on..., spreading the disease, resisting traditional che...he gene, called "Metadherin" or MTDH, is located i... to be crucial to cancer,s spread or metastasis be...
(Date:1/5/2009)...MADISON, WI, January 5, 2009 -- A new calibration ...oil scientists calibrate their thumb and forefinge...bold and colleagues, USDA-NRCS, Lincoln, NE, write... of Natural Resources and Life Sciences Education ...gth of a soil to withstand an applied stress or re...
(Date:1/5/2009)... New Rochelle, NY, January 5, 2009Theodosius Dobz... biologist, said it best: "Nothing in biology make...s year marks the 200th birthday of Charles Darwin ...he publication of the Origin of Species, which lai...selection in exquisite detail. Universities, acade...
(Date:1/5/2009)...WASHINGTON -- The engineering profession,s highest...y of Engineering (NAE), recognize three achievemen...ed to the widespread production of antibiotics; an...a for engineers. , ROBERT H. DENNARD will rece...a $500,000 annual award that honors engineers whos...
Breaking Biology News(10 mins):Team finds breast cancer gene linked to disease spread 2Team finds breast cancer gene linked to disease spread 3Team finds breast cancer gene linked to disease spread 4Team finds breast cancer gene linked to disease spread 5Describing soils: Calibration tool for teaching soil rupture resistance 2GEN joins Charles Darwin 2009 celebration 2Developer of advanced computing memory, father of biochemical engineering, and innovative engineering educators win highest engineering honors of 2009 2Developer of advanced computing memory, father of biochemical engineering, and innovative engineering educators win highest engineering honors of 2009 3Developer of advanced computing memory, father of biochemical engineering, and innovative engineering educators win highest engineering honors of 2009 4Identical twins not as identical as believed 2222 1Coming to the Defense of Cats 12057 1Coming to the Defense of Cats 12057 2Synvista Therapeutics to Present at the Roth 20th Annual OC Growth Stock Conference 12053 1Synvista Therapeutics to Present at the Roth 20th Annual OC Growth Stock Conference 12053 2Synvista Therapeutics to Present at the Roth 20th Annual OC Growth Stock Conference 12053 3Personalized medicine can cut breast cancer risk 12050 1Personalized medicine can cut breast cancer risk 12050 2
...chers studying rapamycin, an antibiotic used to bo...und that the drug may protect the heart against ti...e July issue of the Journal of Molecular and Cellu...ternational Society for Heart Research, researcher...t with a clinically relevant dose of rapamycin ind...
...of Health have discovered that a rare tumor of the...eficiency of an important enzyme. The enzyme is on...,s response to hormones and appears to stop cells ...netics, was conducted by researchers in NIH,s Nati...nt. The NIH group collaborated with scientists fr...
...al Science, researchers at the University of Texa...riments that may soon lead to a test that will ena...e infected with the human form of mad cow disease,...ting itself. , Such a blood test could also help p...oteins that cause variant Creutzfeldt-Jakob diseas...
...stors picking stocks, humans make a wide range of ... However, laboratory studies have not been able to...ation-processing "subcortical" regions of the brai...Steven Quartz and colleagues at the California Ins...g task that, when performed by humans undergoing f...
Other Biology News:New study shows antibiotic may protect the heart 2Lack of key enzyme associated with development of rare tumor 2Prion find points way to test for human 'mad cow' disease 2Brain's 'gambling circuitry' identified 2Brain's 'gambling circuitry' identified 3
(Date:1/6/2009)...Zealand, Jan. 6 MicroDose Technolo...that they have entered into a collaboration to inv...ive(TM) technology with MicroDose,s next generatio...terms of the agreement, MicroDose will fund the de...aler platform and incorporating Nexus6,s Smartinha...
(Date:1/6/2009)...utoGenomics, a leader in providing automated, mole...company has been invited and has accepted to prese...ll be held January 12-15, 2009 at the Westin St. F...nce, Fareed Kureshy, President & CEO will prov...ay, January 13, 2009. , , About JPMorgan 27th A...
(Date:1/6/2009)...ent to innovation in drug-eluting stent technology...l/ -- Boston Scientific Corporation (NYSE: BSX )...ted, a privately held, development-stage drug-elut...eland. Terms of the acquisition were not disclose... for coating drug-eluting stents that uses precise...
(Date:1/6/2009)...-FirstCall/ -- China Sky One Medical,Inc. ("Chin...KI ), a leading,fully integrated pharmaceutical c...ople,s Republic of China ("PRC"), announced today ...in TDR Medical Science and Technology,Heilongjia...gineering, have,been granted the High-Technology ...
Breaking Biology Technology:MicroDose and Nexus6 Announce Collaboration to Evaluate Application of Remote Patient Compliance Monitoring Technology with MicroDose's Electronic Dry Powder Inhaler 2MicroDose and Nexus6 Announce Collaboration to Evaluate Application of Remote Patient Compliance Monitoring Technology with MicroDose's Electronic Dry Powder Inhaler 3Boston Scientific Acquires Labcoat Limited 2Boston Scientific Acquires Labcoat Limited 3Boston Scientific Acquires Labcoat Limited 4China Sky One Medical, Inc. Qualifies for Preferential Income Tax Rate 2China Sky One Medical, Inc. Qualifies for Preferential Income Tax Rate 3
...mes to securing information networks, Paul Barford... the guys in the black hats. , ,Barford, an assis...ison Department of Computer Sciences , said the ac...1 shows no signs of abating. In fact, the fun-seek...iety have been joined by a more sophisticated clas...
..., and blessed with majestic mountains, fertile val...r views. Oh, and a couple million sheep. After a d...o fly business class), my weary, Northern hemisphe... This is definitely not Kansas Frodo; in fact, its...fter dashing through customs, I am back on a plane...
... the dust has settled in the case of Advanced Cel...ity, just what is the judgment of Wisconsin scient...lif.-based company? , ,The question was put to th...em cell basics at the Medical College of Wisconsi...raud and suggested the company exaggerates its fin...
...s wisely into search engine campaigns on Google ,...ildly leads to ruin. , ,Managing a search engine m...ng any investment portfolio: you want to save as m...ng as much money as possible in areas that are lik... good baseline for your search engine marketing ca...
Other Biology Technology:Safe Internet requires total network security, prof. says 2Safe Internet requires total network security, prof. says 3An upside down view of the future 2An upside down view of the future 3An upside down view of the future 4An upside down view of the future 5Wisconsin researchers defend stem cell company 2Wisconsin researchers defend stem cell company 3Risks and returns: Building a search engine marketing portfolio 2Risks and returns: Building a search engine marketing portfolio 3Risks and returns: Building a search engine marketing portfolio 4
Serum is obtained from non-demolished blood that is collected from healthy, fasted donors. The donors are not medicated in any way and are maintained on an antibiotic free diet. Total Protein Concen
...abeling System - dCTP with CyScribe GFX Purificati...ication of Cy3- and Cy5-labeled cDNA.Optimized rea...ling and purification.Flexible and optimized proto... with either Cy3- or Cy5-labeled nucleotides.Relia...
Canine Serum
UV-NIR light source for USB2000, HR4000, HR2000+
Biology Products: