American Chemical Society's Weekly PressPac -- Nov...(e faulty proteins. Those proteins disru...)

The researchers describe discovery of a family of drug-like molecules that target the errant strands of RNA, preventing production of the defective protein. The discovery, they said, provides scientists for the first time with substances that target the root cause of MMD and represent molecules that could be developed into drugs. They note that drugs more commonly target DNA or proteins, with the RNA approach offering a different and potentially valuable route to developing new medications for certain diseases. JS

ARTICLE #2 FOR IMMEDIATE RELEASE
"Dynamic Combinatorial Selection of Molecules Capable of Inhibiting the (CUG) Repeat RNA-MBNL1 Interaction In Vitro: Discovery of Lead Compounds Targeting Myotonic Dystrophy (DM1)"

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CONTACT:
Benjamin L. Miller, Ph.D.
University of Rochester
Rochester, N.Y.
Office: 585-275-9805
Fax: 585-473-6889
Email: Benjamin_miller@urmc.rochester.edu

Toward healthier bread and other whole grain foods
Journal of Agricultural and Food Chemistry

Bread, pasta, and other foods made from whole grains known to help protect against heart disease, cancer and diabetes may get even healthier in the future. Scientists in Europe collaborating in the European Union HEALTHGRAIN project are reporting the largest study to date comparing nutrient levels in the world's different grain varieties, which could lead to the development of healthier varieties of grain and grain-based foods, they say. Their findings will be described in a group of papers scheduled for the November
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