Navigation Links
'New' estrogen receptor found to be key player in tamoxifen resistance
Date:10/29/2008

Washington, D.C. Researchers at Georgetown University Medical Center have discovered a novel way in which breast cancer cells become resistant to tamoxifen, the world's largest-selling breast cancer prevention and treatment drug. They say the findings could provide a way to identify tamoxifen users who are no longer benefiting from the drug, allowing doctors to try another therapy option sooner.

In the November 1 issue of the journal Cancer Research, the researchers show that breast cancer cells that are resistant to tamoxifen display few of the "alpha" estrogen receptors that the drug is designed to bind on to and inhibit, but many more "gamma" estrogen-related receptors, which tamoxifen seems to activate. These two receptors are not closely related they are more like distant cousins than siblings, researchers say, adding that understanding how these gamma estrogen-related receptors work may eventually help in designing new, more effective drugs targeting these receptors.

In fact, they track how, as resistance develops over time, breast cancer cells gradually lose the alpha receptors while gaining the estrogen-related receptor gamma subtype.

The study offers two new insights, according to lead author Rebecca Riggins, Ph.D., a research assistant professor of oncology at GUMC's Lombardi Comprehensive Cancer Center.

One is a clearer understanding of the importance of the gamma estrogen-related receptor in breast cancer. "Until now, this receptor has not been viewed to be of much importance in any type of breast cancer," Riggins says. "All that was known is that there were more of these receptors in breast cancer than in normal breast tissue, we hadn't gone much further than that."

A second important insight is that the discovery could help explain why invasive lobular carcinoma the sub-type of breast cancer in which these findings were made may not respond as well to tamoxifen as perhaps other subtypes do, she says.

"It is
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
215-514-9751
Georgetown University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. New, more direct pathways from outside the cell-to-cell nuclei discovered
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. New molecular regulators of hyperthyroidism and goiter
4. Newly created cancer stem cells could aid breast cancer research
5. Adding up renewable energy
6. Unravelling new complexity in the genome
7. New study warns limited carbon market puts 20 percent of tropical forest at risk
8. New study examines how rearing environment can alter navigation
9. News tips from the Journal of Neuroscience
10. Dominant cholesterol-metabolism ideas challenged by new research
11. Researchers identify proteins involved in new neurodegenerative syndrome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/8/2009)...ernational GIANT (Genetic Investigation of Anthrop...ery of obesity genes. So far, the scientists have ...ide association studies with a total of more than ...te genes were validated in 14 further studies incl...and MC4R genes already known, it was now possible ...
(Date:1/7/2009)...LPHIA The combination of estrogen plus progestin,...e news that it may increase their risk of breast c...r, according to a report published in the January ...ention , a journal of the American Association for...ever taken these hormones, the use of estrogen plu...
(Date:1/7/2009)...ILLE, Fla. Mercury pollution has already spurred ..., but it could become a more pressing concern in a...s in a recent issue of the journal Oecologia . ,...t the University of Florida and the paper,s lead a...s growing in air enriched with carbon dioxide to s...
(Date:1/7/2009)... Mass. January 07, 2009 A special issue of Amer...europsychiatric Genetics presents a comprehensive...ch of Attention Deficit/Hyperactivity Disorder (AD... complex psychiatric genetics, underscoring how ge...aches are needed to uncover its genetic origins. ,...
Breaking Biology News(10 mins):Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect 2Hormone therapy associated with reduced colorectal cancer risk 2To climate-change worries, add 1 more: Extended mercury threat 2To climate-change worries, add 1 more: Extended mercury threat 3Studies examine genetic determinants of ADHD 2International team compares 12 fruit fly genomes 1157 1International team compares 12 fruit fly genomes 1157 2International team compares 12 fruit fly genomes 1157 3Angiotech To Participate In The American Academy Of Ophthalmology 28AAO 29 2007 Annual Meeting 5915 1Angiotech To Participate In The American Academy Of Ophthalmology 28AAO 29 2007 Annual Meeting 5915 23M Gen Probe to Discontinue Molecular Food Testing Collaboration 5912 13M Gen Probe to Discontinue Molecular Food Testing Collaboration 5912 23M Gen Probe to Discontinue Molecular Food Testing Collaboration 5912 3ThermoGenesis Corp Reports First Quarter 2008 Results 5909 1ThermoGenesis Corp Reports First Quarter 2008 Results 5909 2ThermoGenesis Corp Reports First Quarter 2008 Results 5909 3ThermoGenesis Corp Reports First Quarter 2008 Results 5909 4ThermoGenesis Corp Reports First Quarter 2008 Results 5909 5ThermoGenesis Corp Reports First Quarter 2008 Results 5909 6ThermoGenesis Corp Reports First Quarter 2008 Results 5909 7
...ve sequenced and compared the genomes of planktoni...he Pacific Ocean. The pioneering study yielded ins...ies at each depth--ranging from 40 to more than 13... the genomes of entire microbial communities, we c...stem," said MIT,s Ed DeLong, who led the research ...
... new study explains, for the first time, the failu...our known Dengue viruses, and it suggests a very s...aneously at different locations on the body. , A m...ds of people per year and sickens 100 million more...erized by excruciating pain and was "the most impo...
...ade during the first large-scale analysis of inter... for identifying new genes involved in genetic dis...nd the Institute of Bioinformatics (IOB) in Bangal...f Nature Genetics, were made using a database of m...led by the Hopkins-IOB team. The result is believ...
... male contraception likely to be available in the ...ue of THE LANCET highlight how such contraception ...ilable male contraceptive methods (condoms, withdr...uples because they are either not sufficiently rel...o ovulation suppression by hormone treatment in wo...
Other Biology News:Sequencing our seas 2Sequencing our seas 3Simple idea to dramatically improve dengue vaccinations 2Simple idea to dramatically improve dengue vaccinations 3Largest study of human 'interactome' reveals a novel way 2Largest study of human 'interactome' reveals a novel way 3Hormonal male contraception reversible after few months for all men 2
(Date:1/8/2009)...ERDAM, January 8 ,Agendia, a world...ounced the,appointment of Kurt Schmidt, CPA, MBA,..., "Kurt is an exceptional addition to our tea...h.D., President and Chief Executive Officer. "With... the high tech and healthcare,industries, he will...
(Date:1/8/2009)...rapeutics Inc. announced today the dosing of the f...5156, their targeted antisense therapeutic in mid-...s. , The study, entitled "A Phase 2, Multicenter,...bitor of Apoptosis (XIAP) Antisense AEG35156 Given... Combination of Carboplatin/Paclitaxel Alone In Pa...
(Date:1/8/2009)...Dendreon Corporation (Nasdaq: DNDN ) today annou...al J.P. Morgan Healthcare Conference in San Franci.... , , , A live audio webcast of the presenta...ions section of the Dendreon website, http://www....live webcast, it will be archived on the site foll...
(Date:1/8/2009)...ll/ -- Amicus Therapeutics (Nasdaq: FOLD ) today... its Board of Directors. Dr. Barer currently serv...ene Corporation. As an industry veteran, Dr. Bare...d a reputation as a trusted and respected leader w...rld,s preeminent biopharmaceutical companies. , ...
Breaking Biology Technology:Agendia Appoints New Chief Financial Officer 2Aegera Therapeutics Initiates A Randomized Phase 2 Combination Study of AEG35156 for 1st Line Treatment of Non-Small Cell Lung Cancer 2Amicus Therapeutics Adds Sol J. Barer, Ph.D. to Board of Directors 2
...on, Wis. - University of Wisconsin-Madison rese...20 million grant from the National Institutes of ... , ,The grant is part of a $300 million fund for t...ed by the NIH in 2000 to develop techniques and to...,s Center for Eukaryotic Structural Genomics is ...
...CAGO Its that time again for the half-year round...he U.S. life sciences sector. If you recall the re... for the major indices: , , Dow Jones down 3 perce...q Biotech down 16% percent , Amex Biotech down 9 p...below, the results for the first six months of 200...
..., Wis. - Technology is having a profound impact o...technological advances in such fields as manufactu...ight not realize it. , , Wisconsin Farm Technology...al, WI, will showcase the latest technology develo... fair began on Tuesday, July 12, and runs thru Thu...
...osse, Wis. - Merkle Inc. , has selected La Cross...a data quality software solution, to modify their ...on Quality Suite offers customers the ability to c...tch hundreds of millions of rows of data, and prov...rs also have the ability to have complete views of...
Other Biology Technology:UW-Madison awarded $20 million grant for protein research 2UW-Madison awarded $20 million grant for protein research 3Midwest large cap life sciences mostly outperform market 2Midwest large cap life sciences mostly outperform market 3Farmers explore technology at Wisconsin event 2
...er an optional X-Ray Imaging Module which allows l...d precisely co-register anatomical X-rays of tissu...imaging modalities, improving anatomical localizat...ical and radioisotopic based molecular imaging age...
Telomerase ELISA Assay Kit, TRAPEZE from CHEMICON
Features hardwall acrylic panels mounted on powder-coated steel support frame to form a free-standing modular cleanroom that meets cleanliness to Class 10/ISO 3. Optional ceiling HEPA filter/fan unit
...ker chip to profile the relative abundance of canc... human cancer serum biomarker-specific antibodies....scientists to study panels of biomarkers related t...elihood of recurrence of cancer. Familiar gene exp...
Biology Products: