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New study indicates smallpox vaccination effective for decades
Date:11/30/2008

necessary because multiple vaccinations achieve only marginally higher levels of antibody and virus neutralizing activity than single vaccination.

Writing in the article, Dan L. Longo, MD, National Institute on Aging, states "A major question posed today is whether those individuals vaccinated 40 or more years ago would be protected in the event of smallpox exposure. This may be a critical question because the availability of smallpox vaccines is limited and currently inadequate for a mass inoculation program. We found that vaccinated subjects maintain what appear to be protective levels of neutralizing antibodies to vaccinia indefinitely and do not require booster vaccinations even if they are many decades removed from primary vaccination. These data imply that limited supplies of vaccine can be more usefully applied to individuals who have never been vaccinated, primarily individuals born after 1972."


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Contact: Pamela Poppalardo
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Elsevier Health Sciences
Source:Eurekalert

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Antibodies were affinity purified using epitopes specific to USP33 immobilized on solid support.
Pyrophosphate Fluorometric (Blue) Assay Kit, EnzChek® from Molecular Probes (Invitrogen)
Human VEGF R2 (KDR) MAb (Clone 89106)
X-Gal from Research Organics, Inc.
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