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"Berry, berry, berrygood!"

oak up superoxide, but evidence that these vitamins can play a preventative or curative role in human disease is not strong.

Currently, the consequences of the reaction of NO with superoxide are not fully understood. There is evidence to suggest that such reactions may be beneficial or harmful to processes in the body. It is reasonable to assume however, that any factor that promotes the arterial endothelial NO system and/or suppresses the effects of oxygen radicals in the body has the potential to yield marked cardiovascular benefits to an individual, as well as potentially have positive impacts other major human diseases.

Four Studies
Accordingly, a cluster of new studies examining the effects of the berries on arteries is the basis of a new research investigation, Characterization of Coronary Arterial Reactivity of Berry Anthocyancins, conducted by David R. Bell, Ph. D. and Kristin Gochenaur, B.S., both of the Indiana University School of Medicine, Fort Wayne, Indiana. They will present their findings during the American Physiological Society (APS) annual meeting, which is being held as part of the Experimental Biology conference. More than 14,000 scientific investigators are attending the gathering, which begins April 20-24, 2002 at the Ernest N. Morial Convention Center, New Orleans, LA.

Methodology
The researchers conducted four investigations into potential coronary vascular activity of extracts prepared from elderberry, chokeberry and bilberry. The test arteries used in the investigations were porcine coronary arteries, which share similar a physiology to those in humans. The researchers investigated whether or not:

solutions prepared from the three berry extracts possess direct endothelium-dependent or -independent vasoactivity in coronary arteries;

endothelium-dependent, NO mediated relaxation or direct NO mediated relaxation of coronary arteries is modified in the presence of a physiological conce
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Contact: Donna Krupa
djkrupa1@aol.com
703-967-2751
American Physiological Society
22-Apr-2002


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