"Self Organizing Maps" Help Analyze Thousands Of Genes

Using a sophisticated computer algorithm, a team of scientists at the Whitehead Institute has designed a new technique to analyze the massive amounts of data generated by DNA microarrays, also known as DNA chips. This technique will help scientists decipher how our 100,000 genes work together to keep us healthy and how diseases result when they fail.

"DNA arrays have revolutionized DNA analysis by allowing us to observe the activities of thousands of genes simultaneously," says Todd Golub, research scientist at the Whitehead/MIT Center for Genome Research. "But until now, it's been really difficult to interpret this extraordinarily complex raw data. Our technique is among the first in a new generation of tools that will speed up the analysis of the enormous amounts of genetic data emerging from laboratories worldwide."

Dr. Golub and his colleagues at the Whitehead Institute, Dana-Farber Cancer Institute, Dartmouth Medical School, and the Massachusetts Institute of Technology, report their technique in the March 16 issue of the Proceedings of the National Academy of Sciences. The Whitehead/MIT Center for Genome Research is one of the flagship centers of the U.S. Human Genome Project, the effort to determine the 3 billion letters that make up the human blueprint.

"The core of the technique is an algorithm, called a self-organizing map (SOM), that takes advantage of the fact that many genes in a cell behave similarly," explains Pablo Tamayo, the lead author of the paper and research scientist at the Whitehead Institute. "Instead of having 2,000 individual genes, all doing different things, you might have 25 groups of genes doing similar things."

Tamayo compares the final product of the SOM to an executive summary for CEOs. Rather than having to read every page of a 1,000-page report, CEOs can get an overview of the report by simply reading the summary. "It's impossible to visually inspect every gene," he says. "This method produces a qu

Contact: Stefanie Doebler
Whitehead Institute for Biomedical Research

Page: 1 2

Related biology news :

1. Researchers Analyze Role Of Shear In Turbine Passage
2. University Of Cincinnati Geologists Analyzes Evolutionary Impact Of Mass Extinctions
3. Genes expose secrets of sex on the side
4. Genes can influence both alcohol consumption and dependence
5. Genes may be central to cocaine addiction
6. Genes appear to play a role in development of chronic obstructive pulmonary disease
7. Genes make the marsh
8. Genes predict response of adult leukemia patients to chemotherapy
9. Genes influence memory in families with Alzheimers disease
10. Genes control severity of heart failure, study finds
11. Genes that regulate hearing link humans and fruit flies in new way

Post Your Comments:

(Date:10/4/2019)... ... October 03, 2019 , ... Mount Sinai researchers have discovered ... down from one generation to the next. In a study published in Nature Structural ... of this enzyme, leading to cancers and other diseases. , “DNA polymerase delta serves ...
(Date:9/30/2019)... ... September 30, 2019 , ... Foresight Institute, a leading think ... technologies, announced the winners for the 2019 Foresight Institute Feynman Prizes. These are ... nanotechnology/molecular manufacturing. , Established in 1993 and named in honor of pioneer physicist ...
(Date:9/30/2019)... (PRWEB) , ... September 30, ... ... leading think tank, research, and public interest organization focused on molecular manufacturing ... Student Prize. , The Award recognizes the College graduate or undergraduate student ...
Breaking Biology News(10 mins):
(Date:10/10/2019)... ... October 10, 2019 , ... R3 Stem Cell announces it has ... October 18-19th, 2019 in Las Vegas with spots still open. , The speaker, Dr. ... several Ivy League universities including Cornell, Harvard and Dartmouth. He currently serves as the ...
(Date:10/8/2019)... ... October 08, 2019 , ... Today, Massachusetts stem cell biotechnology company Asymmetrex ... Like the company’s precursor patent, approved in the U.S. in 2017, the new patent ... Asymmetrex now markets the technology in the U.S. as the AlphaSTEM Test™. ...
(Date:10/3/2019)... MURRIETA, Calif. (PRWEB) , ... October 02, 2019 , ... ... its business opportunity to investors and venture capital companies in Silicon Valley at a ... to 8:30 pm. The event will be held at the JJ Lake Business Center ...
(Date:9/30/2019)... ... September 30, 2019 , ... The September 2019 edition ... , is now available online on the company’s global website. The Bridge features ... diffraction, fluorescence and imaging, and presents articles, scientific papers and news reports. ...
Breaking Biology Technology:
Cached News: