$24-million grant funds local researchers to create encyclopedia of the innate immune system

The National Institute of Allergy and Infectious Diseases (NIAID) has awarded a multi-year, $24-million grant to a group of researchers at The Scripps Research Institute (TSRI) in La Jolla, the Institute for Systems Biology (ISB) in Seattle, Washington, and The Rockefeller University in New York, New York.

The group's task is to create an "encyclopedia" of innate immunity--a comprehensive and detailed picture of this ancient, essential first line of defense against bacterial and fungal diseases that is mustered by humans, fruit flies, and all creatures in between.

"There are lots of questions we would like to ask about gene expression and protein expression in innate immunity," says TSRI Professor and Chair of Immunology Richard J. Ulevitch, Ph.D., the project's principal investigator. "But to accomplish this in the broadest terms we need to define gene and protein expression patterns when the innate immune system is triggered by invading microbes."

The funds will go towards discovering new ways to study the immune system in living tissue in real time and to provide materials and information to the scientific community at large. Knowledge generated could help scientists develop treatments for septic shock, certain autoimmune disorders, and diseases caused by potential agents of bioterrorism.

A Systems Approach to Innate Immunity

Innate immunity is essential for survival in a world filled with microbial pathogens. Cells of the innate immune system are the body's first responders, arriving soon after foreign elements are detected. Some innate cells find and engulf microorganisms, while others release chemicals that kill the organism directly. Still other cells begin recruiting other specialized immune components to the region.

Severe defects in the innate immune system make humans highly susceptible to normally benign infections, which can then become life threatening. For instance, babies born without functional

Contact: Jason Bardi
Scripps Research Institute

Page: 1 2 3

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. Schepens Eye Research Institute receives Roadmap grant to develop center for curing eye diseases
3. Florida Tech earns $50,000 grant to create coral database
4. $7.5 Million grant to Yale researchers for role of viruses in cancer
5. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
6. $2.7 million grant to support creation of virtual zebrafish atlas
7. Brown ecologist garners major National Science Foundation grant
8. Ecology of infectious diseases grants awarded
9. University of Pittsburgh receives $10 million grant for head and neck cancer
10. UCR earns $1.5 million grant to examine how engineered crop genes stray
11. NSF awards $10 million in grants to ocean sites for long-term ecological research

Post Your Comments:

(Date:1/21/2019)... ... ... Energetiq Technology, a world leader in high brightness broadband light sources, will ... Photonics West events taking place in San Francisco on February 1 – February 7, ... booth #941 at Photonics West. There will be live demonstrations of Energetiq’s ultra-bright broadband ...
(Date:1/20/2019)... (PRWEB) , ... January 16, 2019 , ... January has ... cooking events company. Not only has the company already hosted several of its ... Fortune 500 companies, Amazon and Janssen Pharmaceuticals, later this month. , Since 2008, ...
(Date:1/14/2019)... ... January 14, 2019 , ... CellMax Life , a ... blood, will present new findings at the ASCO Gastrointestinal Cancer Symposium in San ... results from this study show CellMax Life’s blood test, based on its proprietary ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... ... January 30, 2019 , ... Through ... awarded microbiome research support in study design, planning, sample collection, and analysis to ... Marc D. Cook, PhD, to study the interactions between gut microbial composition and ...
(Date:1/28/2019)... ... January 28, 2019 , ... Fragment-based lead discovery ... In this early stage, false positives can be problematic due to high levels ... that screening techniques are highly sensitive to detect weak interactions. Nanomed , ...
(Date:1/24/2019)... Calif. (PRWEB) , ... January 22, 2019 , ... Dr. ... using the Pall Veterinary Platelet Enhancement Therapy System (V-PET™) for nearly three ... VetStem Regenerative Cell Therapy since 2007 and began using V-PET™ 2016. ...
(Date:1/24/2019)... ... January 23, 2019 , ... Through ... awarded microbiome research support in study design, planning, sample collection, and analysis to ... St. Augustine Campus in Trinidad led by Dr. Elaine Monica Davis, MBBS, MPhil, ...
Breaking Biology Technology:
Cached News: