to persist in patients in a latent state for many years, are the focus of George Miller, M.D., John Enders Professor of Pediatrics and professor of Molecular Biophysics and Biochemistry and Epidemiology and Public Health. His laboratory is analyzing molecular events that maintain these viruses in the latent state, and the mechanisms for inducing these viruses to re-enter active growth.

Joan Steitz, Sterling Professor of Molecular Biophysics and Biochemistry, also works on herpesviruses, focusing on the role of small viral RNAs in the induction and maintenance of tumors. Many RNAs that she studies were first identified in the collaboration with Miller supported by this grant.

Joann Sweasy, associate professor of Therapeutic Radiology and Genetics, investigates the role of mutant DNA polymerases in inducing cancer. Collaborating with DiMaio, she has found that some cancers may be due to inaccurate DNA synthesis by error-prone DNA polymerases.

"Working collaboratively on these related projects has enabled us to make much more rapid progress in understanding the molecular basis of cancer," said DiMaio.

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Contact: Janet Rettig Emanuel
janet.emanuel@yale.edu
203-432-2157
Yale University
22-Sep-2004

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