HOME >> BIOLOGY >> NEWS
$8 million grant establishes program to uncover genetics of asthma

Durham, N.C. -- Duke University Medical Center researchers have set out to uncover the genetic basis of environmental asthma. By revealing how genes interact with such environmental factors as air pollutants, the five-year $8 million program promises to reveal multiple genetic risk factors that predispose patients to the chronic airway disease.

That knowledge might then be applied to develop and test new drugs targeted to particular forms of asthma, for example those associated with exposure to allergens or environmental irritants such as ozone, said David A. Schwartz, M.D., chief of pulmonary medicine at Duke and principal investigator of the new program.

The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, will fund the research.

"The ultimate goal of the new program is to determine which genes make people susceptible to specific types of asthma," Schwartz said. "The program will use information about which environmental factors induce asthma symptoms in particular patients to identify the genes that can contribute to different forms of this very prevalent disease."

The new Duke program will use multiple approaches to uncover the underlying cellular and genetic mechanisms that contribute to environmental asthma. Using a technique called gene expression profiling, the researchers will screen the activity of thousands of genes to identify those involved when the airways of asthma patients become obstructed or inflamed. Learning how these genes differ among individuals might help explain why some people develop asthma while others remain unaffected.

A second component of the program, led by Duke pulmonary scientist W. Michael Foster, Ph.D., will probe the lung's response to ozone -- a common component of air pollution -- in patients with and without asthma. Jonathan Stamler, M.D., a Howard Hughes Medical Institute investigator at Duke, will lead an effort to learn how shift
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-4148
Duke University Medical Center
22-Sep-2003


Page: 1 2

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. Half-million dollar landmark achieved for the Methuselah Mouse Prize
3. HHMI, NIBIB/NIH to invest up to $35 million in interdisciplinary Ph.D. programs
4. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
5. $2.7 million grant to support creation of virtual zebrafish atlas
6. Tufts University establishes $4 million dollar tissue engineering resource center
7. PNNL lands $10.3 million NIH biodefense contract to unlock proteomes of salmonella and pox
8. $18 million bioinformatics center to become weapon against deadly diseases
9. Pacific Northwest National Laboratory gets $10 million from NIH to build virtual lung
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. UCR earns $1.5 million grant to examine how engineered crop genes stray

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/3/2016)... June 3, 2016 ... Nepal hat ein ... hochsicherer geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und ... der Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche ... im Januar teilgenommen, aber Decatur wurde als ...
(Date:5/24/2016)... IRVINE, Calif. , May 24, 2016 Ampronix facilitates superior patient care ... LMD3251MT  3D medical LCD display is the latest premium product recently added to ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
Breaking Biology News(10 mins):
(Date:6/27/2016)...  Global demand for enzymes is forecast to ... $7.2 billion.  This market includes enzymes used in ... production, animal feed, and other markets) and specialty ... and beverages will remain the largest market for ... products containing enzymes in developing regions.  These and ...
(Date:6/27/2016)... San Diego, CA (PRWEB) , ... June 27, 2016 , ... ... mClinical solutions for clinical trials, announced today the Clinical Reach Virtual Patient ... and their care circle with the physician and clinical trial team. , Using the ...
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks ... to industrial engineering, was today awarded as one ... selection of the world,s most innovative companies. Ginkgo ... scale for the real world in the nutrition, ... engineers work directly with customers including Fortune 500 ...
(Date:6/24/2016)... ... 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in Ancona ... or pleural mesothelioma. Their findings are the subject of a new article on the ... are signposts in the blood, lung fluid or tissue of mesothelioma patients that can ...
Breaking Biology Technology:
Cached News: