HOME >> BIOLOGY >> NEWS
$8 million grant establishes program to uncover genetics of asthma

Durham, N.C. -- Duke University Medical Center researchers have set out to uncover the genetic basis of environmental asthma. By revealing how genes interact with such environmental factors as air pollutants, the five-year $8 million program promises to reveal multiple genetic risk factors that predispose patients to the chronic airway disease.

That knowledge might then be applied to develop and test new drugs targeted to particular forms of asthma, for example those associated with exposure to allergens or environmental irritants such as ozone, said David A. Schwartz, M.D., chief of pulmonary medicine at Duke and principal investigator of the new program.

The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, will fund the research.

"The ultimate goal of the new program is to determine which genes make people susceptible to specific types of asthma," Schwartz said. "The program will use information about which environmental factors induce asthma symptoms in particular patients to identify the genes that can contribute to different forms of this very prevalent disease."

The new Duke program will use multiple approaches to uncover the underlying cellular and genetic mechanisms that contribute to environmental asthma. Using a technique called gene expression profiling, the researchers will screen the activity of thousands of genes to identify those involved when the airways of asthma patients become obstructed or inflamed. Learning how these genes differ among individuals might help explain why some people develop asthma while others remain unaffected.

A second component of the program, led by Duke pulmonary scientist W. Michael Foster, Ph.D., will probe the lung's response to ozone -- a common component of air pollution -- in patients with and without asthma. Jonathan Stamler, M.D., a Howard Hughes Medical Institute investigator at Duke, will lead an effort to learn how shift
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-684-4148
Duke University Medical Center
22-Sep-2003


Page: 1 2

Related biology news :

1. UT Southwestern receives $1.78 million grant for obesity research as part of NIH Roadmap initiative
2. Half-million dollar landmark achieved for the Methuselah Mouse Prize
3. HHMI, NIBIB/NIH to invest up to $35 million in interdisciplinary Ph.D. programs
4. Northeastern University receives $12.4 million NSF grant for creation of nanomanufacturing institute
5. $2.7 million grant to support creation of virtual zebrafish atlas
6. Tufts University establishes $4 million dollar tissue engineering resource center
7. PNNL lands $10.3 million NIH biodefense contract to unlock proteomes of salmonella and pox
8. $18 million bioinformatics center to become weapon against deadly diseases
9. Pacific Northwest National Laboratory gets $10 million from NIH to build virtual lung
10. University of Pittsburgh receives $10 million grant for head and neck cancer
11. UCR earns $1.5 million grant to examine how engineered crop genes stray

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: