HOME >> BIOLOGY >> NEWS
Science: Prion proteins may signal trouble -- literally

This release is also available in French.

PARIS -- A harmless form of the scrapie prion--an abnormally folded protein that leads to brain-degenerating diseases in humans, sheep, and cows--may help regulate nerve-cell functions through cellular signaling, researchers report in the 15 September issue of the international journal, Science.

While irregular prions are the known culprits behind incurable "spongey-brain" diseases, or transmissible spongiform encephalopathies (TSEs), the purpose of normal prions has remained mysterious until recently.

According to research teams directed by Odile Kellermann of the Institute Pasteur in Paris and Jean-Marie Launay of Hospital Lariboisire, unraveling the signal-carrying pathway of the normal prion (PrPc) will help reveal what triggers its activity, and later, how its corrupt form (PrPSc) wrecks cellular processes, causing the neurodegeneration of scrapie.

The non-pathogenic prion protein is not known to play a role in a specific cell function, researchers said. But, normal prions may fine-tune neuronal functions at the cellular level, since they are sited at nerve-cell surfaces, particularly in the outstretched arms of neurons called neurites, which collect and integrate information from other neurons.

Normal prions appear to participate in a signaling "cascade" that activates an enzyme called "Fyn," The Fyn enzyme is a tyrosine kinase capable of stimulating multiple intracellular events that change, for example, a cell's responsiveness to other nervous stimuli, said Odile Kellermann and her collaborator, Sophie Mouillet-Richard, lead author of the Science paper.

The research team identified two forms of a caveolin-1 protein, and possibly another protein, clathrin, which also appeared to participate in the activation of Fyn. Other cellular partners
'"/>

Contact: Ginger Pinholster
gpinhols@aaas.org
202-326-6440
American Association for the Advancement of Science
14-Sep-2000


Page: 1 2

Related biology news :

1. Prion propagation: Avoiding the toxic oligomer
2. Prions act as stepping stones in evolution
3. Prions offer nanotech building tool
4. Prion disease may be caused by buildup of cellular trash, say Stanford researchers
5. Prions may play crucial role in evolution.
6. Prions are modular
7. New Evidence On How Prions Turn Fatal
8. University Of California-San Francisco Researchers Report Test That Detects Prion Diseases, Illuminates Novel Findings About Infectious Prions
9. Progress In Prion Research: Three-Dimensional Structure Of Prion Protein Fully Uncovered
10. New molecular link key to cellular proteins involved in cancer progression, other diseases
11. New dye directly reveals activated proteins in living cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... October 04, 2018 , ... CallTower ... solutions, was present at Microsoft Ignite 2018, in Orlando, Florida, when Microsoft made ... issued a statement about the new direction of Skype for Business Online, outlining ...
(Date:10/5/2018)... (PRWEB) , ... October 04, 2018 , ... Nothing brings ... classes have become so popular. , Cooking appeals to companies because it ... group interaction, team cohesion, collaboration and decision-making skills. It’s also appealing in that ...
(Date:10/2/2018)... ... October 02, 2018 , ... Stuart is a fun-loving eight-year-old Labrador retriever. Like many labs, ... Cynthia, “He loves playing ball so much that whenever anyone comes to our door, he ... game of fetch.” In early 2017, Stuart began limping and eventually could no longer ...
Breaking Biology News(10 mins):
(Date:10/17/2018)... , ... October 17, 2018 , ... ... and Phytophthora spp. have been validated by USDA’s Animal and Plant Health Inspection ... can use the assays with confidence and trust, knowing they will be able ...
(Date:10/13/2018)... ... October 12, 2018 , ... The ... education, innovation and commercialization, celebrates its 50th birthday in New York’s Times Square ... and Electro-Optics (ICALEO) conference. , In celebration of its 50 years, LIA ...
(Date:10/5/2018)... ... October 04, 2018 , ... ... genomics, along with Duke University, announced today at IDWeek™ 2018 the positive results ... detects pathogen DNA in plasma, accurately identified causative pathogens in patients with infective ...
(Date:10/2/2018)... ... 2018 , ... Finalists for the 2018 World Oil Awards ... was chosen for its advancements in the production chemicals category. The prestigious awards, ... oil applications that are positively impacting the industry. The winners will be announced ...
Breaking Biology Technology:
Cached News: