HOME >> BIOLOGY >> NEWS
Science: Prion proteins may signal trouble -- literally

This release is also available in French.

PARIS -- A harmless form of the scrapie prion--an abnormally folded protein that leads to brain-degenerating diseases in humans, sheep, and cows--may help regulate nerve-cell functions through cellular signaling, researchers report in the 15 September issue of the international journal, Science.

While irregular prions are the known culprits behind incurable "spongey-brain" diseases, or transmissible spongiform encephalopathies (TSEs), the purpose of normal prions has remained mysterious until recently.

According to research teams directed by Odile Kellermann of the Institute Pasteur in Paris and Jean-Marie Launay of Hospital Lariboisire, unraveling the signal-carrying pathway of the normal prion (PrPc) will help reveal what triggers its activity, and later, how its corrupt form (PrPSc) wrecks cellular processes, causing the neurodegeneration of scrapie.

The non-pathogenic prion protein is not known to play a role in a specific cell function, researchers said. But, normal prions may fine-tune neuronal functions at the cellular level, since they are sited at nerve-cell surfaces, particularly in the outstretched arms of neurons called neurites, which collect and integrate information from other neurons.

Normal prions appear to participate in a signaling "cascade" that activates an enzyme called "Fyn," The Fyn enzyme is a tyrosine kinase capable of stimulating multiple intracellular events that change, for example, a cell's responsiveness to other nervous stimuli, said Odile Kellermann and her collaborator, Sophie Mouillet-Richard, lead author of the Science paper.

The research team identified two forms of a caveolin-1 protein, and possibly another protein, clathrin, which also appeared to participate in the activation of Fyn. Other cellular partners
'"/>

Contact: Ginger Pinholster
gpinhols@aaas.org
202-326-6440
American Association for the Advancement of Science
14-Sep-2000


Page: 1 2

Related biology news :

1. Prion propagation: Avoiding the toxic oligomer
2. Prions act as stepping stones in evolution
3. Prions offer nanotech building tool
4. Prion disease may be caused by buildup of cellular trash, say Stanford researchers
5. Prions may play crucial role in evolution.
6. Prions are modular
7. New Evidence On How Prions Turn Fatal
8. University Of California-San Francisco Researchers Report Test That Detects Prion Diseases, Illuminates Novel Findings About Infectious Prions
9. Progress In Prion Research: Three-Dimensional Structure Of Prion Protein Fully Uncovered
10. New molecular link key to cellular proteins involved in cancer progression, other diseases
11. New dye directly reveals activated proteins in living cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2018)... RESTON, Va. (PRWEB) , ... August 14, 2018 ... ... stigmas were recently depicted in the movie “Wonder,” to a better understanding of ... defects treatments, according to editors of the latest special issue of Birth ...
(Date:8/7/2018)... EDWARDSVILLE, Ill. (PRWEB) , ... August 06, 2018 ... ... corn growing in front of The NCERC at Southern Illinois University Edwardsville’s University ... corn, but also grain sorghum and sweet sorghum. These three feedstocks represent conventional ...
(Date:8/2/2018)... ... August 02, 2018 , ... The ... innovator Boston Heart Diagnostics to its Lifestyle Medicine Corporate Roundtable, a group of ... care system and a sustainable world. , Boston Heart is transforming the ...
Breaking Biology News(10 mins):
(Date:7/25/2018)... MATEO, Calif. (PRWEB) , ... July 25, 2018 ... ... for in vivo research utilizing its state-of-the-art Digital Vivarium™ and Vium Cloud approach ... Schaevitz, Ph.D., to Chief Scientific Officer. Additionally, the company announced the appointment of ...
(Date:7/25/2018)... ... July 25, 2018 , ... John McDonald, CEO ... board of the Indiana India Business Council (IIBC), an advocacy group to strengthen ... current board of directors, McDonald joins an impressive roster of local and national ...
(Date:7/24/2018)... ... July 24, 2018 , ... Boval was founded in 1978 ... reagent suppliers. In Boval’s early days most of the BSA manufactured was for ... BSA for diagnostic purposes after gel cards changed that market and displaced most of ...
(Date:7/22/2018)... ... July 19, 2018 , ... Mitotech ... with Essex Bio-Investment for Phase 3 clinical program in Dry Eye Disease. Under ... SkQ1 with approximately $17m allocated towards the first Phase 3 study starting as ...
Breaking Biology Technology:
Cached News: