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15 Drugs, Dyes And Other Chemicals Newly Listed As Known Or Likely Human Carcinogens

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Newly listed as known human carcinogens:

CYCLOSPORIN, an immunosuppressive drug.

THIOTEPA, a drug used to treat lymphomas and tumors of the breast and ovary. It has also been used at high doses in combination chemotherapy with cyclophosphamide in patients with refractory malignancies treated with autologous bone transplantation.

Newly listed as Reasonably Anticipated to be Human Carcinogens:

AZACITIDINE, a drug used to treat acute leukemia.

p-CHLORO-o-TOLUIDINE and its HC1 salt, used to produce azo dyes for cotton, silk acetate and nylon and as intermediate in production of Pigment Red 7 and Pigment Yellow 49. Also an impurity in and metabolite of the pesticide chlordimeform.

CHLOROZOTOCIN, a drug used to treat cancers of the stomach, large intestine, pancreas and lung; melanoma; and multiple myeloma.

DANTHRON, or dantron, a laxative removed from the market several years ago when tests were published indicating it caused cancer in laboratory animals. It is also an intermediate in the manufacture of dyes.

1,6-DINITROPYRENE. No commercial uses but is detected in ambient atmospheric samples and as a constituent of diesel exhaust.

1,8-DINITROPYRENE. Also in diesel exhaust and air samples.

DISPERSE BLUE 1, used as an anthraquinone-based dyestuff in several semi-permanent hair dyes and also in coloring fabrics and plastics

FURAN, used as a chemical intermediate in the synthesis and production of other organic compounds.

O-NITROANISOLE, used as a precursor in the synthesis of o-anisidine which is used in the manufacture of more than 100 azo dyes.

6-NITROCHRYSENE. Not used commercially, but detected in ambient atmospheric samples.

1-NITROPYRENE. Not used commercially, detected in ambient atmospheric samples and as a constituent of diesel exhaust.

4-NITROPYRENE. Not used commercially, detected in ambient atmospheric samples.

1,2,3-TRICHLOROPROPANE, used as a polymer crosslinking
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Contact: Sandy Lange
Lange@niehs.nih.gov
(919) 541-0530
NIH/National Institute of Environmental Health Sciences
14-May-1998


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