HOME >> BIOLOGY >> NEWS
22nd amino acid synthesized and added to genetic code of e. coli bacteria

COLUMBUS, Ohio Two years ago, Ohio State University researchers surprised the scientific community by announcing their discovery of a 22nd genetically encoded amino acid.

Now they have capped that discovery with news that they have successfully synthesized the amino acid itself L-pyrrolysine and shown that bacteria can incorporate it into new proteins the biological components which do most of the work in cells.

The importance of their work is the explanation of exactly how the 22nd amino acid is incorporated into proteins inside living cells. The genetic instructions to put pyrrolysine into proteins follows a traditional path that many scientists had not predicted.

For decades following the discovery of the structure of DNA, the dogma was that the genes in the DNA were decoded to produce proteins built from only 20 "canonical" amino acids.

But in 1986, researchers discovered that a 21st amino acid selenocysteine was incorporated into certain proteins. What separated selenocysteine from the other previously identified amino acids was the fact that it was inserted into protein by a very different path.

Each of the canonical amino acids uses a specialized translator protein to decode genetic information as that amino acid. But selenocysteine lacked its own translator protein and is put into the protein through a more circuitous route.

That left open the question of whether future amino acids would follow the traditional path of the first 20 amino acids or the unusual route taken by 21st.

In the end, tradition won out.

The results are described in two papers published in scientific journals this month. The first appeared in the British journal Nature and the second in the journal Chemistry and Biology.

"In recent years, researchers learned to artificially modify a set of translator enzymes so that new amino acids can be genetically programmed in cells to produce novel proteins for biotechnolo
'"/>

Contact: Joseph A. Krzycki
Krzycki.1@osu.edu
614-292-1578
Ohio State University
17-Sep-2004


Page: 1 2 3

Related biology news :

1. 22-amino acid bacterium created by Scripps scientists
2. Extraterrestrial enigma: missing amino acids in meteorites
3. Scientists at TSRI create new strain of yeast with 21-amino acid genetic code
4. Research shows high doses of acetaminophen clear rapidly and consistently from bloodstream
5. Expanding the genetic code--TSRI scientists synthesize 21-amino-acid bacterium
6. UT Southwestern researchers say overdoses of acetaminophen cause most cases of acute liver failure
7. Understanding acetaminophen poisoning
8. Acetaminophen may protect against heart damage according to Rutgers research
9. New amino acid discovered; Fundamental building block of life
10. Moving gene in plant results in increased production of amino acid
11. Scientists probing the origins of life develop method of making novel proteins using a 21st amino acid

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), Biometrics, Card-Based ... & Logistics, Government & Public Sector, Utilities / Energy ... Nuclear Power), Industrial, Retail, Business Organisation (BFSI), Hospitality & ... for a definitive report on the $27.9bn Access Control ... ...
(Date:4/5/2017)... YORK , April 5, 2017 Today ... is announcing that the server component of the HYPR ... known for providing the end-to-end security architecture that empowers ... HYPR has already secured over 15 million ... makers including manufacturers of connected home product suites and ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... , ... August 16, 2017 , ... ... microbe delivery system, announced it has secured $2M in funding from an impressive ... Angels, Carmen Innovations, and SVG Thrive Fund. With this investment, 3Bar is broadening ...
(Date:8/16/2017)... BOSTON and OXFORD, England , ... -based consortium for biotech executive search and leadership development, ... and Healthcare sectors, have created an exclusive alliance that enables ... "For our clients here ... collaboration provides unparalleled access to a diverse population of leadership ...
(Date:8/15/2017)... ... August 15, 2017 , ... Nanomedical Diagnostics , ... development, announces the launch of the new NHS Agile biosensor chip . ... data for a wide range of molecules, including small and large molecules, peptides, ...
(Date:8/15/2017)... ... 15, 2017 , ... Kenall, a leader in sealed solid-state ... tightly sealed and perform efficiently for years. The downlights are ideal for a ... enough, such as: hospitals; behavioral health facilities; cleanrooms; containment areas; food and pharmaceutical ...
Breaking Biology Technology:
Cached News: