HOME >> BIOLOGY >> NEWS
3-D Structure Of HIV Components May Pave The Way For New Anti-AIDS Drugs

As HIV appears to outmaneuver even the latest drug combinations, researchers are scrambling for new attack strategies. New molecular details about one HIV protein may provide just that--the basis for an entirely new class of highly specific anti-AIDS drugs.

Scientists working with support from NIH's National Institute of General Medical Sciences have determined the three-dimensional molecular structure of the HIV nucleocapsid protein bound to the virus' genetic material (RNA, or ribonucleic acid). The nucleocapsid protein is responsible for stuffing viral genes into new viral particles. The protein is a prime target for anti-AIDS drugs, because previous studies have shown that when it is crippled, HIV cannot spread to other cells. New drugs that block the action of the RNA component could be equally important.

The detailed structure of the protein-RNA complex, determined using a technique called nuclear magnetic resonance (NMR) spectroscopy, is published in the January 16 issue of Science.

"The structure is significant for two main reasons. First, it provides molecular insights into how the protein recognizes and binds to [a specific site on viral] RNA. Second, it provides a structural basis for the development of drugs that are designed to disrupt this recognition and binding, and thus prevent the spread of the virus," said Dr. Michael F. Summers, lead author of the study and a professor of biophysical and bioinorganic chemistry at the University of Maryland Baltimore County (UMBC). Dr. Summers is also an associate investigator of the Howard Hughes Medical Institute.

Like a father recognizing his child in a crowded classroom, nucleocapsid plucks from the infected cellular melange only the specific viral RNA needed to form new viral particles. Nucleocapsid recognizes and binds to only the few RNA strands that contain a site called the packaging domain, said coauthor Dr. Philip
'"/>

Contact: Alisa Zapp Machalek
zappa@nigms.nih.gov
(301) 496-7301
NIH/National Institute of General Medical Sciences
15-Jan-1998


Page: 1 2

Related biology news :

1. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
2. Structure solved by Scripps scientists shows one way that body controls gene expression
3. Structure of a Nobel-prize winning molecule: Aquaporin
4. Structure of HIV-neutralizing antibody solved
5. Structure of key breast cancer receptor determined
6. Structure of cog at the hub of metabolism reveals anti-ageing function
7. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
8. Structure reveals details of cells cargo-carriers
9. Structure of key receptor unlocked; Related proteins will fall like dominoes
10. New Science Press launches Proteins: From Sequence to Structure
11. Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
(Date:3/24/2017)... 24, 2017 Research and Markets has announced ... Analysis & Trends - Industry Forecast to 2025" report to ... The ... a CAGR of around 15.1% over the next decade to reach ... analyzes the market estimates and forecasts for all the given segments ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... San Diego, CA (PRWEB) , ... ... ... BioInformatics (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform ... eliminating all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, ...
(Date:10/11/2017)... ... October 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its ... 2018 in San Francisco, CA. The Summit brings together current and former FDA office ... directors and government officials from around the world to address key issues in device ...
(Date:10/11/2017)... Tbilisi, Georgia (PRWEB) , ... October 11, 2017 , ... ... disaster, taking the lives of over 5.5 million people each year. Especially those living ... the greenovative startup Treepex - based in one of the most pollution-affected countries globally ...
(Date:10/10/2017)... , ... October 10, 2017 ... ... cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing ... HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s ...
Breaking Biology Technology:
Cached News: