HOME >> BIOLOGY >> NEWS
3-D Structure of Human Tumor-Suppressor Protein Produced

COLUMBUS, Ohio -- Researchers here have determined the three-dimensional structure of the protein produced by one of the most important human tumor-suppressor genes.

The gene is the p16 tumor-suppressor gene. The protein produced by this gene, the p16 protein, normally prevents cells from dividing when they shouldn’t.

When this protein is missing or inactivated due to mutations in the p16 tumor-suppressor gene, cancer can occur. In fact, damage to the p16 protein is a factor in more than 70 different types of cancer.

The researchers have also produced computer-generated pictures of the protein.

“This was a major achievement because of the importance of this protein in cancer and because of the difficulty of the project,” said Ming-Daw Tsai, the researcher at Ohio State University’s Comprehensive Cancer Center who led the study.

“If we can develop a drug that mimics p16, that would be a potentially good approach for the treatment of cancer, which is the ultimate goal of work like this.

“Determining the structure of the protein is the first major step in developing such a drug,” said Tsai, a professor of chemistry and of biochemistry.

The study, conducted by Tsai and a team of Ohio State researchers, was published in a February issue of the journal Molecular Cell. They used nuclear magnetic resonance (NMR) spectroscopy to measure the location of the atoms within the protein and their distances from one another. This information was then fed into a computer to determine the molecule’s structure.

NMR spectroscopy uses a powerful magnetic field to make molecular measurements. The method enables the researchers to study the structure of the p16 protein in a water solution, which more closely represents the molecule’s structure as it would exist inside the cell.

This, in turn, will make it easier through further research to determine the protein’
'"/>

Contact: Ming-Daw Tsai
Tsai.7@osu.edu
(614) 292-3080
Ohio State University
2-Mar-1998


Page: 1 2

Related biology news :

1. Structure solved at Scripps shows how one human protein reduces potency of chemotherapy
2. Structure solved by Scripps scientists shows one way that body controls gene expression
3. Structure of a Nobel-prize winning molecule: Aquaporin
4. Structure of HIV-neutralizing antibody solved
5. Structure of key breast cancer receptor determined
6. Structure of cog at the hub of metabolism reveals anti-ageing function
7. Structure of pain-modulating enzyme described by scientists at the Scripps Research Institute
8. Structure reveals details of cells cargo-carriers
9. Structure of key receptor unlocked; Related proteins will fall like dominoes
10. New Science Press launches Proteins: From Sequence to Structure
11. Third piece completes deadly puzzle: Structure of anthrax toxin offers clues to treatment

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... 4, 2017 KEY FINDINGS The ... at a CAGR of 25.76% during the forecast period ... primary factor for the growth of the stem cell ... MARKET INSIGHTS The global stem cell market ... and geography. The stem cell market of the product ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
(Date:3/24/2017)... Research and Markets has announced the addition ... Trends - Industry Forecast to 2025" report to their offering. ... The Global Biometric ... of around 15.1% over the next decade to reach approximately $1,580 ... market estimates and forecasts for all the given segments on global ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... , ... June 21, 2017 , ... ... office in North Carolina, and engages Timothy Reinhardt to manage the new site. ... leadership at Pfizer Inc, with his most recent role as the Director of ...
(Date:6/22/2017)... ... June 22, 2017 , ... ... designating infertility as a disease, bringing new hope for prospective parents who are ... annual meeting to back the World Health Organization’s designation in hopes of changing ...
(Date:6/22/2017)... ... 2017 , ... The first human cell line HeLa, established in 1951, has ... cross-contamination of human cell lines with HeLa cells were published. Until recently, cross-contamination and ... and is associated with dramatic consequences for research. , In this educational webinar, ...
(Date:6/20/2017)... ... June 20, 2017 , ... CTNext , ... directors has formed a Higher Education Entrepreneurship Advisory Committee to implement the recommendations ... and other high-ranking representatives from 35 higher education institutions across the state over ...
Breaking Biology Technology:
Cached News: