A New Encyclopedia Of Mouse Genes

February 1, 1999 -- The laboratory mouse, small and easy to breed, has long been biologists' favorite model organism for studying mammalian development. Now, a multi-laboratory project with collaboration from the Howard Hughes Medical Institute has produced a free, publicly accessible catalog of mouse gene fragments that will help ensure that the mouse remains an important model in the genomic era.

The catalog, a collection of more than 360,000 gene fragments, is helping scientists get a handle on particular genes that they want to study. The database, which is available on the Internet at http://genome.wustl.edu/est/mouse_esthmpg.html, should also be a valuable tool for interpreting and comparing the genome sequences of mouse and human as vast stretches of chromosome sequence are cranked out in the months and years ahead.

Marco Marra of the Washington University Genome Sequencing Center in St. Louis led a team of 42 scientists who surveyed the genes of the mouse, hoping to snare many genes that are important during development. In the February 1999 issue of the journal Nature Genetics, the researchers describe how they generated their large database of expressed sequence tags (ESTs).

ESTs provide quick access to genes. They are fragments of sequences from messenger RNA molecules, the molecules that act as intermediaries between genes and proteins.

Since the array of messenger RNA molecules in a cell varies according to the type of cell and its developmental stage, the biologists generated ESTs from a broad range of cell types to get the largest possible sample of genes. The ESTs arose from various adult mouse organs as well as from mice in the earliest stages of development.

"The mouse provides a very powerful mammalian model system," Marra points out. "If we want to understand the function of a human g

Contact: Jim Keeley
Howard Hughes Medical Institute

Page: 1 2 3

Related biology news :

1. Half-million dollar landmark achieved for the Methuselah Mouse Prize
2. Mouse study shows NPAS3 and NPAS1 genes may be linked to psychosis
3. Mouse brain stem cells capable of converting into blood vessel cells
4. Mouse study yields clue to why liver is less prone to rejection, say Pitt researchers
5. Mouse embryonic germ cells and male gametes created in the lab
6. Mouse, stripped of a key gene, resists diabetes
7. Mouse model of schizophrenia could speed identification of new antipsychotic drugs
8. Mouse study identifies protective mechanism against alcohol-induced embryo toxicity
9. Mouse model offers new explanation for kidney disease and failure
10. Mouse study suggests mammoth evolutionary change
11. Mouse genetic model for spongiform brain diseases

Post Your Comments:

(Date:5/8/2019)... ... May 08, 2019 , ... RG+A, Inc., a leading ... Mann has agreed to serve as Chief Executive Officer and pharmaceutical leader Dr. ... immediately. They will join Chairman and Founder Roger Green to create a three-person ...
(Date:5/7/2019)... ... May 07, 2019 , ... ... Legionella DNA test in the UK. , In May, Landsec will undertake trials ... in 45 minutes, enabling operators to take corrective action within hours instead of ...
(Date:5/2/2019)... ... May 01, 2019 , ... Gateway Genomics ... future children, announces a new publication titled, “ Self-Collection of Maternal Blood for ... Child Health. Previous studies had only shown early gender determination using venous blood. ...
Breaking Biology News(10 mins):
(Date:4/16/2019)... ... April 16, 2019 , ... ... and technology, today announced that Bank South Pacific (BSP), the largest regionally owned ... The bank awarded Fulcrum a contract to deliver a fingerprint-based Know Your Customer ...
(Date:4/9/2019)... , ... April 09, 2019 , ... ... focused on increasing the capacity of life sciences organizations to accelerate innovation and ... Assurance platform in the past 12 months. , USDM’s Cloud Assurance ...
(Date:4/8/2019)... , ... April 09, 2019 , ... ... the innovative non-profit research center Chan Zuckerberg Biohub (CZ Biohub) has chosen Geneious ... antibody repertoires is part of CZ Biohub’s efforts to establish new approaches to ...
(Date:3/27/2019)... ... March 27, 2019 , ... In honor of National Nutrition Month, Lajollacooks4u has ... healthy meals and good nutrition. This month, Chef Jodi Abel appeared on two ... , The first segment addressed the nutritional value of USDA’s MyPlate, a nutrition ...
Breaking Biology Technology:
Cached News: