A Versatile Signal In Vertebrate Embryogenesis: Wnt-4 Regulates Kidney Development, Sex Organ Differentiation, Neuronal Survival And Axonal Guidance

Researchers at the Max Planck Institute for Immunobiology, at Harvard University, at Oulu University /Finland and at the University of California characterised the important signalling role of a secreted protein of the Wnt family in kidney development, sex organ differentiation and axonal growth and guidance in vertebrate embryogenesis. (Development 125, 4225-4234, 1998; Nature 397, 405-409, 1999; Science 283, 1180-1183,1999)

The formation of vertebrate organs is a complex process. It is characterised by the interaction of different cells and tissues to assure the concerted program of cell growth, differentiation and morphogenesis which garanties the functional architecture of the adult organ. Cell and tissue interactions are mediated by signalling molecules of various protein classes.

The mammalian kidney has been widely exploited as a model system to study the principles of vertebrate organ formation. Kidney development is characterized by an interaction between an epithelial and a mesenchymal compartment: the Wolffian duct and the nephrogenic mesenchyme. Dependent on signals from the mesenchyme, the ureter will give rise to the adult collecting duct system whereas the mesenchyme upon signals from the ureter will differentiate to form the major part of the nephrons, the functional unit of the excretory system, which is responsible for removal of nitrogenous waste and physiological control of salt balance.

An important family of signalling molecules is encoded by Wnt genes. Wnt proteins are secreted glycoproteins which have been shown to regulate numerous developmental processes like brain formation, limb patterning, and axis formation in the vertebrate embryo.

Classical experiments demonstrated the reciprocal nature of inductive events in the kidney using tissue separation and recombination techniques. The ureteric bud induces the mesenchyme to condense and to form tubules - precursors to nephrons. The mesenchyme in turn promotes ureteric bud

Contact: Andreas Kispert

Page: 1 2 3

Related biology news :

1. Versatile immunosuppressant drug may have new role in radiotherapy for cancer
2. Epilepsy: Signals brake in brain impaired
3. Signal chemical primes plants for pest attack
4. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
5. Small G-Proteins Make A Big Difference -- Nerve Cell Signalling Is Regulated By Arf-GTPases And Their Activators
6. How Nerve Cells Get In Touch - A Molecular Model Of Synapse Formation And Retrograde Signalling In The Brain
7. Cell Suicide Prevented By Survival Signals
8. Plant-Based Fat Inhibits Cancer-Cell Growth By Enhancing Cells Signaling System, UB Researchers Show
9. Toxic Protein That Interferes With Brain Signals May Trigger Onset Of Alzheimers Disease
10. R-Type Channels - A New Type Of Calcium Channels Controlling Signal Transduction Between Neurons In The Brain
11. Cholesterol Anchor Helps Signaling Proteins Direct Development

Post Your Comments:

(Date:11/27/2019)... ... November 27, 2019 , ... ... device, equipped with surface electromyography (sEMG) sensors that measure and display muscle activity ... the specific muscles being targeted for treatment. Both patient and therapist can see ...
(Date:11/19/2019)... ... November 19, 2019 , ... The inaugural Cell & Gene Therapy ... York City. The one-day event will be chaired by Dr Aiman Shalabi, VP R&D, ... space. , “We are witnessing significant innovation in cell and gene therapies, and ...
(Date:11/12/2019)... ... November 12, 2019 , ... ... the design and manufacturer of technical ergonomic seating solutions, announced this week ... with Healthier Hospital Initiative guidelines. Established by Practice Greenhealth, a health care ...
Breaking Biology News(10 mins):
(Date:10/29/2019)... ... 29, 2019 , ... Researchers at Sony recently demonstrated biometric ... imagers , researchers identified people by the image of a small patch on ... recognition, fingerprints and vasculature. , The new CMS4 series of cameras offer ...
(Date:10/22/2019)... ... 2019 , ... nQ Medical, Inc. of Cambridge, MA, was recognized in the ... was announced at a showcase event yesterday in Los Angeles. nQ competed against 3,500 ... and impressive near-term growth projections to be named one of the most fundable companies ...
(Date:10/22/2019)... ... 22, 2019 , ... Enplug , a leading cloud-based ... into its digital signage platform. The collaboration brings one of the most trusted ... to leverage their existing digital signage networks to quickly disseminate critical safety information ...
(Date:10/17/2019)... ... October 15, 2019 , ... TopConsumerReviews.com recently gave ... DNA Testing for health and/or genealogy research purposes. , There are many reasons ... people want to know more about themselves at a cellular level: family history, ...
Breaking Biology Technology:
Cached News: