HOME >> BIOLOGY >> NEWS
A Versatile Signal In Vertebrate Embryogenesis: Wnt-4 Regulates Kidney Development, Sex Organ Differentiation, Neuronal Survival And Axonal Guidance

Researchers at the Max Planck Institute for Immunobiology, at Harvard University, at Oulu University /Finland and at the University of California characterised the important signalling role of a secreted protein of the Wnt family in kidney development, sex organ differentiation and axonal growth and guidance in vertebrate embryogenesis. (Development 125, 4225-4234, 1998; Nature 397, 405-409, 1999; Science 283, 1180-1183,1999)

The formation of vertebrate organs is a complex process. It is characterised by the interaction of different cells and tissues to assure the concerted program of cell growth, differentiation and morphogenesis which garanties the functional architecture of the adult organ. Cell and tissue interactions are mediated by signalling molecules of various protein classes.

The mammalian kidney has been widely exploited as a model system to study the principles of vertebrate organ formation. Kidney development is characterized by an interaction between an epithelial and a mesenchymal compartment: the Wolffian duct and the nephrogenic mesenchyme. Dependent on signals from the mesenchyme, the ureter will give rise to the adult collecting duct system whereas the mesenchyme upon signals from the ureter will differentiate to form the major part of the nephrons, the functional unit of the excretory system, which is responsible for removal of nitrogenous waste and physiological control of salt balance.

An important family of signalling molecules is encoded by Wnt genes. Wnt proteins are secreted glycoproteins which have been shown to regulate numerous developmental processes like brain formation, limb patterning, and axis formation in the vertebrate embryo.

Classical experiments demonstrated the reciprocal nature of inductive events in the kidney using tissue separation and recombination techniques. The ureteric bud induces the mesenchyme to condense and to form tubules - precursors to nephrons. The mesenchyme in turn promotes ureteric bud
'"/>

Contact: Andreas Kispert
kispert@immunbio.mpg.de
49-76-1-51-08-4
Max-Planck-Gesellschaft
2-Mar-1999


Page: 1 2 3

Related biology news :

1. Versatile immunosuppressant drug may have new role in radiotherapy for cancer
2. Epilepsy: Signals brake in brain impaired
3. Signal chemical primes plants for pest attack
4. Reproductive Signals Affect Lifespan In Roundworm C. Elegans, Offering Possible Insight Into Human Aging Process
5. Small G-Proteins Make A Big Difference -- Nerve Cell Signalling Is Regulated By Arf-GTPases And Their Activators
6. How Nerve Cells Get In Touch - A Molecular Model Of Synapse Formation And Retrograde Signalling In The Brain
7. Cell Suicide Prevented By Survival Signals
8. Plant-Based Fat Inhibits Cancer-Cell Growth By Enhancing Cells Signaling System, UB Researchers Show
9. Toxic Protein That Interferes With Brain Signals May Trigger Onset Of Alzheimers Disease
10. R-Type Channels - A New Type Of Calcium Channels Controlling Signal Transduction Between Neurons In The Brain
11. Cholesterol Anchor Helps Signaling Proteins Direct Development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2020)... , ... April 27, 2020 , ... ... category-defining service was started by three teenagers with an idea to help millions ... world during the time of great need and suffering, an outlet has been ...
(Date:4/23/2020)... Wis. (PRWEB) , ... April 23, 2020 , ... ... its expansion and recruitment plans. MDG provides critical infrastructure products for the animal ... push MDG’s previous plans for expansion. Further, as supply channels from overseas competitors ...
(Date:4/22/2020)... Calif. (PRWEB) , ... April 21, 2020 , ... ... driving digital transformation and innovation in technology and compliance, announces a new managed ... a best-in-class trio of alliances – Box, ComplianceQuest, and USDM Life Sciences (USDM) ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... ... 13, 2020 , ... Early stages of drug discovery often ... information on the drug’s mechanism of action (MOA). Gene expression profiling technologies like ... activity of molecular pathways. This information can complement phenotypic readouts and can be ...
(Date:5/5/2020)... , ... May 05, 2020 , ... ... company, announced today the launch of its iGlucose® LTE Cat-M Cellular ... solution utilizes LTE Cat-M1 technology, the industry’s newest and broadest cellular connectivity available, ...
(Date:4/22/2020)... BUDAPEST, Hungary and CAMBRIDGE, Mass. (PRWEB) , ... ... ... headquartered in Budapest with US offices in Cambridge, MA, announced today that Omixon’s ... Meintjes led the early commercialisation of Omixon’s flagship product Holotype HLA since 2014 ...
(Date:4/7/2020)... ... 06, 2020 , ... Gateway Genomics , leading developer of direct-to-consumer genetic ... Gender DNA Tests sold in March, just months after attaining the 150,000-test landmark ... where a mom could order her kit online, collect a DNA sample from her ...
Breaking Biology Technology:
Cached News: