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A Versatile Signal In Vertebrate Embryogenesis: Wnt-4 Regulates Kidney Development, Sex Organ Differentiation, Neuronal Survival And Axonal Guidance

nal outgrowth and target innervation of sensory neurons depends on factors secreted by their environment. Neurotrophins are a class of proteins that mediate these functions on neurons as demonstrated by the fact that in the absence of Neurotrophin-3 most sensory neurons are lost before they can reach their target tissues.

Ardem Patapoutian in Louis Reichardt's laboratory at the University of California in San Francisco was investigating the regulation of Neurotrophin-3 expression and found that axons are not required for NT-3 expression but local signals from the environment. In the limb bud signals from the ectoderm, the outer epithelial layer, are responsible for NT-3 expression in the underlying mesenchyme. Using the Wnt expressing cell lines provided by Andreas Kispert from the Max Planck Institute for Immunobiology he could demonstrate that Wnt proteins, in particular Wnt-4, can mimick the ectodermal signal and induce NT-3 expression in isolated limb bud mesenchyme.

These studies have identified Wnt-4 as a key signalling molecule mediating tissue interactions in developmental contexts as diverse as kidney development, sex organ formation, and neuronal growth and axonal guidance.


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Contact: Andreas Kispert
kispert@immunbio.mpg.de
49-76-1-51-08-4
Max-Planck-Gesellschaft
2-Mar-1999


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