HOME >> BIOLOGY >> NEWS
A big surprise: Young nerve cells can rewind their developmental clocks

Scientists have identified a gene in the cerebral cortex that apparently controls the developmental clock of embryonic nerve cells, a finding that could open another door to tissue replacement therapy in the central nervous system. In a new study, the researchers found that they could rewind the clock in young cortical cells in mice by eliminating a gene called Foxg1. The finding could potentially form the basis of a new method to push progenitor cells in the brain to generate a far wider array of tissue than is now possible.

The study, led by researchers at NYU School of Medicine, is published in the January 2, 2004 issue of Science magazine.

"What we found was a complete surprise," says Gordon Fishell, Ph.D., Associate Professor in the Department of Cell Biology at New York University School of Medicine. "No one had believed that it was possible to push back the birth date of a cortical neuron. There is this central tenet governing the process of brain development, which says that late progenitor cells [forerunners of mature cell types] cannot give rise to cell types produced earlier in development," he explains.

"Consequently, while some populations of stem cells exist in the adult brain, these cells are restricted to producing only a subset of cell types," notes Dr. Fishell. "If one's goal is to produce cells for replacement therapy, some method must be found to turn back the clock and allow adult stem cells to give rise to the wide variety of cells made during normal brain development."

Eseng Lai, Ph.D., of Merck & Co. and one of the study's co-authors, cloned the Foxg1 gene while he was working at Memorial Sloan-Kettering Cancer Center in New York. He also did seminal work in the late 1990s showing that when the gene is eliminated in embryonic mice, the brain's cerebral hemispheres barely develop. Subsequent work demonstrated that the gene played a role in the early phases of cortical development.
'"/>

Contact: Pamela McDonnell
Pamela.Mcdonnell@med.nyu.edu
212-404-3555
New York University Medical Center and School of Medicine
1-Jan-2004


Page: 1 2 3

Related biology news :

1. A shocking surprise: High voltage + rats = ozone, reopens power-line debate
2. Another global warming surprise: Grasslands may become wetter as temperatures rise
3. Climate change surprise: High carbon dioxide levels can retard plant growth, study reveals
4. Surprise, surprise, surprise: Hopkins scientists unexpectedly create epilepsy in rats
5. Second call for proposals for the European Young Investigator Award
6. Kiratisin wins 2004 Dade MicroScan Young Investigator Award
7. APS announces four 2004 Young Investigators awards
8. Young chimpanzees show sex differences in learning
9. Young scientists awarded for achievements in cancer research
10. Young cancer researchers honored
11. Young sea animals clone themselvescentury-old debate halted

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/15/2017)... ivWatch LLC , a medical device company focused on improving the ... its ISO 13485 Certification, the global standard for medical device quality ... ... device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, as it validates ...
(Date:7/20/2017)... DAL ) customers now can use fingerprints instead of their ... (DCA). ... launches biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May at ... process to allow eligible Delta SkyMiles Members who are enrolled in CLEAR ...
(Date:6/30/2017)... ARLINGTON, Va. , June 30, 2017 /PRNewswire-USNewswire/ ... a leading developer and supplier of face and ... the ATA Featured Product provider program. ... created an innovative way to monitor a driver,s ... benefit greatly from being able to detect fatigue ...
Breaking Biology News(10 mins):
(Date:8/17/2017)... (PRWEB) , ... August 17, 2017 , ... ... the stock market news outlet had provided a research update on Aytu Bioscience ... administered TRT product. , According to Soulstring, prescription rates for Natesto® have more ...
(Date:8/17/2017)... ... August 17, 2017 , ... Cynvenio Biosystems, ... today announced the launch of a new breast cancer monitoring study in partnership ... to evaluate the potential for early detection of recurrent breast cancer using LiquidBiopsy ...
(Date:8/16/2017)... ... August 16, 2017 , ... Tunnell Consulting announced ... at the ISPE Annual Meeting and Expo , to be held October 29 ... event’s theme is “Driving innovation to advance patient therapies.” , The ISPE Annual Meeting ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... the Fluidnatek® Electrospinning and Electrospraying line of nanofiber ... from table-top equipment for the lab to fully automated pilot plants and ...
Breaking Biology Technology:
Cached News: