HOME >> BIOLOGY >> NEWS
A cholesterol-controlling drug could strike a blow against insulin resistance

April 9, 2003 (San Diego, CA) -- In industrialized countries insulin resistance/diabetes have become major public health concerns because of their epidemic growth and their association with major cardiovascular risk factors that are responsible for excess morbidity and mortality. In 1999, Americans had a six percent increase in new patients with Type 2 diabetes; growing obesity rates and sedentary lifestyles are also taking their toll across the Atlantic where Type 2 diabetes currently afflicts 22.5 million Europeans -- a staggering five percent of the population -- with another six million cases expected by 2025.

Researchers are looking for underlying mechanisms and new ways to combat this epidemic. Over the past decade, evidence has accumulated indicating that nitric oxide (NO) may play a key role in the control of metabolic and cardiovascular homeostasis, as evidenced by mice lacking the gene for endothelial nitric oxide synthase (eNOS) that are insulin resistant and hypertensive. An animal study now finds that stimulating NO bioavailability by lipid lowering statins may represent a new way to combat this epidemic.

Statins are a group of compounds that have been used successfully to lower cholesterol and prevent myocardial infarction. A less well known effect of statins is that they augment NO bioavailability in circulation. Abnormalities in the body's production of NO have been implicated in high blood pressure, atherosclerosis (narrowing of the arteries), diabetes, impotence, and stroke.

One statin is the prescription drug Simvastatin, used with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. Accumulation of cholesterol and fats along the walls of the arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to the heart, brain, and other parts of the body. Lowering your blood level of cholesterol and fats ma
'"/>

Contact: Donna Krupa
djkrupa1@aol.com
703-967-2751
American Physiological Society
9-Apr-2003


Page: 1 2

Related biology news :

1. Landmark agreement between Samoa and UC Berkeley could help search for AIDS cure
2. Circulation of disaster myths in Haiti could hinder appropriate disposal of bodies
3. New study indicates arsenic could be suitable as first-line treatment in type of leukaemia
4. Marijuana use could cause tubal pregnancies
5. Gene chips research in cotton could lead to superior variety
6. Groundbreaking research could ignite new solutions to heat transfer in nano-devices
7. Bullish chemical could repel yellow fever mosquitoes
8. Termites could hold the key to self-sufficient buildings
9. Wastewater could treat itself, power city
10. Sugar-coated sea urchin eggs could have sweet implications for human fertility
11. Identifying tick genes could halt disease, bioterrorism threat

Post Your Comments:
(Date:7/22/2014)... UT Arlington computer science and engineering professor with an ... three-year National Science Foundation grant worth more than $600,000 ... the fruit fly., Heng Huang, an associate professor, will ... the UT Arlington Computer Science and Engineering department. Scientists ... because a large number of genes involved in fruit ...
(Date:7/22/2014)... be good for the average steak, but it seems ... to survive Alaska,s winter cold. , "Alaska wood frogs ... steak does in your freezer and the frog comes ... than the steak," said Don Larson, University of Alaska ... paper demonstrating that freeze tolerance in Alaska wood frogs ...
(Date:7/22/2014)... Researchers from the USC Schaeffer Center for Health ... governing antipsychotic drugs with increased incarceration rates for ... scrutiny over whether cutbacks in mental health actually ... account. , Some health plans require an extra ... ordered for patients. This step called prior ...
Breaking Biology News(10 mins):UT Arlington big data team wins $600,000 NSF grant to build gene expression database 2Alaska frogs reach record lows in extreme temperature survival 2Alaska frogs reach record lows in extreme temperature survival 3Are state Medicaid policies sentencing people with mental illnesses to prison? 2
(Date:7/23/2014)... , July 23, 2014 regulated information -- UCB ... and development pipeline with positive topline results from ... . This study was designed to evaluate the efficacy ... 200 mg/day, without titration) compared to placebo, as ... partial-onset seizures, not fully controlled despite treatment with ...
(Date:7/23/2014)... , July 23, 2014 China Cord Blood Corporation (NYSE: ... leading provider of cord blood collection, laboratory testing, hematopoietic ... Limited ("Cordlife"), a multi-product healthcare company catering to the mother and ... in assisting patients across the PRC, Singapore , ... India , the Philippines ...
(Date:7/23/2014)... July 23, 2014 Adult stem ... therapies are biological, but not magical. However, ... to treat them as if they were magical. ... unsanctioned studies that constitute “stem cell tourism,” are ... approach to developing new regenerative medicine therapies. In ...
(Date:7/22/2014)... a phylum so full of mean little creatures, the yellow-colored ... cruelty -- at least to crickets. Native to the southeastern ... predatory sort of parasite. It swoops onto the back of ... leaves its wicked brood to invade, kill and consume the ... be possible without the fly,s ability to find a cricket ...
Breaking Biology Technology:Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 2China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 3China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 4The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 2The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 3The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 4The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development 5Fly-inspired sound detector 2Fly-inspired sound detector 3Fly-inspired sound detector 4
Cached News: