HOME >> BIOLOGY >> NEWS
A detour for stalled intracellular lipid traffic

The NPC1 protein, which is defective in the glycosphingolipid (GSL) storage disease Niemann-Pick disease type C (NP-C), resides in the cell?s endosomes, Golgi stacks, and lysosomes. Defects in this protein cause free cholesterol, rather than cholesterol esters (CEs), to accumulate in these organelles and interfere with the normal routing of internalized GSLs to the Golgi apparatus. Pagano?s group has found that the normal Golgi trafficking of GSLs involves caveolae or some similar specialized membrane domain and differs from the better known mechanism involving clathrin-coated vesicles, which is used by other endocytosed lipids and proteins. How NPC1 defects affect this caveolar pathway is uncertain, but these authors have proposed that high intracellular cholesterol levels interfere with the normal flux of vesicles through the Golgi apparatus and the endosomes. The current work by Choudhury et al. demonstrates that a previously unsuspected detour can be found around this intracellular roadblock. These authors have studied the biochemical requirements for intracellular transport of fluorescent lipid analogs, and they have implicated two small GTP binding proteins, Rab7 and Rab9, in the clathrin-independent trafficking of GSLs. Overexpression of either protein not only restores their normal patterns of GSL trafficking in NP-C cells, but also reverses their abnormal accumulation of free cholesterol. These molecules thus appear to be limiting for caveolar endocytosis in the mutant cells, suggesting that treatments that increase their activity could reverse the cellular phenotype in NP-C.


'"/>

Contact: John Ashkenas
scied@the-jci.org
416-946-7593
Journal of Clinical Investigation
12-Jun-2002


Page: 1

Related biology news :

1. Manatee population rising in some regions, likely stalled or declining in others
2. Secret to Listerias virulence provides clues to workings of other deadly intracellular pathogens, UC Berkeley scientists report
3. Salmonella infects cells and saves itself by altering host membrane lipids
4. Linking the immune system with lipid metabolism
5. UT Southwestern scientist receives international award for lipid research
6. Ketogenic diet raises cholesterol, lipid levels in children
7. Bacterial proteins cause autoimmunity in the antiphospholipid syndrome
8. USF presents new research on hyperlipidemic children
9. Kansas State University nutrition research finds: Eggs have a lipid that lowers cholesterol absorption
10. Energy-restricted diets shown to be best for improving lipid profiles
11. Smooth regulation of lipid metabolism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/9/2019)... ... July 08, 2019 , ... ... the biotechnology hub of Cambridge, MA. This expansion strengthens KMK’s presence for the ... , and sales force effectiveness consulting for the biotechnology corridor. With ...
(Date:7/5/2019)... ... July 05, 2019 , ... SteriTrack Inc. is ... Platform to governments around the world. , Powered by Microsoft Azure, the ... care solutions to operating theatres worldwide to address new global regulations mandating all ...
(Date:6/25/2019)... ... June 25, 2019 , ... ActX has launched a medical ... from 23andMe, customers can get access to professionally reviewed genetic screening similar to ... Ancestry and Health + Ancestry customers., With the ActX + 23andMe service, both ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... More ... the Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, last ... Urandir detailed the results of some research carried out by the association, in ...
(Date:5/2/2019)... ... April 30, 2019 , ... ... REPROCELL USA Inc. has demonstrated its ability to provide various services and ... to enhance customer satisfaction through the effective implementation of its quality management ...
(Date:5/2/2019)... TORONTO (PRWEB) , ... May 02, 2019 , ... Stay ... pharma, biotech, medical device and food industries. Access to all webinars is free, so ... stay relevant in your field! , Visit http://www.xtalks.com to see our upcoming ...
(Date:5/2/2019)... (PRWEB) , ... May 02, 2019 , ... ... transplantation clinic in the greater Boston area. Gone are the days of painful ... ARTAS® iX Robotic Hair Restoration System is the only robotic intelligent solution to ...
Breaking Biology Technology:
Cached News: