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A genetic contribution to obsessive compulsive disorder

ARTICLE: 5HT1Db receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study.

AUTHORS: E Mundo, MA Richter, G Zai, F Sam , J McBride, F Macciardi and JL Kennedy

Neurogenetics Section and Anxiety Disorders Clinic, Centre for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto (ON), Canada.

Obsessive-Compulsive Disorder (OCD) is a severe psychiatric condition affecting up to 3% of the general population lifetime. It is characterized by intrusive unwanted thoughts (obsessions) and the need to perform repetitive acts or rituals in order to alleviate the anxiety (compulsions). As an example, a patient who fears contamination would be afraid of touching anything and would feel that they must wash their hands over and over.

The causes of OCD remain obscure. However, there is strong evidence for a genetic component (the risk of developing OCD is higher in the relatives of affected), and for the involvement of the serotonin (5HT) neurochemical system. Serotonin is a neurotransmitter that is essential for communication between cells, and it is possible that the receptors that tell how much serotonin should be released may be altered in OCD patients.

The researchers studied the DNA sequence of the gene for one of the receptors of the 5HT system (the 5HT1Dbeta) that regulates 5HT release. They studied families with at least one subject affected by OCD. The genetic make up of the parents was compared to that of the patients to determine if DNA is a reason for OCD. The parents of patients were found to pass on more often one of the variants of the 5HT1Dbeta receptor gene to their affected offspring.

This shows that a person who inherits that variant of the gene has an increased chance of developing OCD.

The study findings, published in the September issue of Molecular Psychiatry, are clear-cut and are set to turn fu
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Contact: Frank Sissingh
molecularpsychiatry@mednet.ucla.edu
310-206-6739
Molecular Psychiatry
3-Sep-2002


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