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A green tea extract could help alleviate shortage of livers available for transplant

on in experimental animals and humans. Green tea contains high levels of polyphenols including catechin, epicatechin, gallocatechin, epigallocatechin, epicatechin gallate and gallocatechin gallate. Considerable epidemiological and experimental evidence shows beneficial effects of green tea extract in reducing the risk of heart disease and cancer, most likely due to the antioxidant property of polyphenols.

Previous studies conducted by North Carolina researchers showed that the feeding of green tea extract dramatically decreased liver injury after warm ischemia/reperfusion, or the return of blood flow, in a rat model, indicating that green tea extract could be an effective therapy clinically to prevent hepatic injury in disease status where an inadequate supply of blood occurs, such as trauma, hemorrhagic shock and hepatic surgery including tumor resection and transplantation.

The Study
Zhi Zhong, PhD., John J. Lemasters, M.D., Ph.D., Ronald G. Thurman, PhD., and their colleagues from the Departments of Cell & Developmental Biology and Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina and Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC set out to test the hypothesis that green tea extract blocks free radical formation and thus prevents primary graft failure after transplantation of fatty livers from ethanol-fed rats. Dr. Zhong will present the findings from their study entitled, "Extracts of Polyphenols from Camellia sinenesis (Green Tea) Prevent Primary Graft Failure after Transplantation of Fatty Livers, during the American Physiological Society (APS) annual meeting, which is being held as part of the Experimental Biology (EB 02) meeting. More than 12,000 scientific investigators are attending the conference, which begins April 20-24, 2002 at the Ernest N. Morial Convention Center, New Orleans, LA.

Methodology
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Contact: Donna Krupa
703-967-2751
American Physiological Society
22-Apr-2002


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