HOME >> BIOLOGY >> NEWS
A green tea extract could help alleviate shortage of livers available for transplant

nebriating dose of alcohol was given to rats by gavage to mimic binge drinking. Livers were explanted 20 hours later, stored in University of Wisconsin cold storage solution for 24 hours and rinsed with lactated Ringers solution containing green tea extract prior to implantation. Free radicals in bile were trapped with a-(4-pyridyl 1-oxide)-N-tert-butylnitrone (4-POBN) and measured using an electron spin resonance spectrometer. 4-Hydroxynenonal, an end-product of lipid peroxidation, was detected immunohistochemically. Transaminase release, liver pathology, and graft survival after transplantation were observed.

Results
Transaminase or enzyme release after liver transplantation was 4-fold higher in rats that received fatty grafts than in rats with healthy control grafts.

Ethanol also caused severe focal necrosis in the liver and decreased survival rates from 88 percent to 13 percent.

Green tea extract largely blunted graft injury and increased survival of fatty livers to 75 percent.

Ethanol administered to donor rats increased POBN/radical adducts 2.5-fold and caused accumulation of 4-hydroxynenonal, a product of lipid peroxidation, after transplantation. These effects were largely blocked by green tea extract or epigallocatechin gallate, a major polyphenolic component of green tea extract.

Conclusion
The study confirms the association of increased free radical formation and graft failure after transplantation of fatty livers from ethanol-treated donors. Further, the work documents that scavenging of free radicals in fatty livers by green tea extract prevents such liver graft damage and failure. Green tea polyphenols could thus be an effective therapy to prevent failure of fatty grafts after clinical liver transplantation and lead to the inclusion of previously rejected livers into the pool of organs available for transplantation.


'"/>

Contact: Donna Krupa
703-967-2751
American Physiological Society
22-Apr-2002


Page: 1 2 3

Related biology news :

1. Plants will not save us from greenhouse gases
2. Environmental decontamination, greenhouse gases, and the genome of a methane-loving bacterium
3. Spring through fall, cities are greener longer than neighboring rural regions
4. Urban heat islands make cities greener
5. Carnegie Mellon University hosts ACS-PRF summer school on green chemistry
6. New space-borne instrument to track greenhouse gases, ozone destroyers, and other pollutants
7. The amendment to the law on green Genetic Engineering inhibits innovation and research in Germany
8. UK small firms pay lip service to green issues
9. Continents played key role in collapse and regeneration of Earths early greenhouse, geologists say
10. White tea beats green tea in fighting germs
11. Improved crop production and fewer greenhouse gases

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... SAN DIEGO and SHANGHAI (PRWEB) , ... August ... ... company pursuing novel approaches for the treatment of chronic inflammatory and fibrotic diseases, ... Operating Officer and Vice President of Drug Discovery. , Dr. Canan previously served ...
(Date:8/23/2020)... ... August 21, 2020 , ... ... has been published and is now available on the company’s global website. Crystallography ... X-ray analysis community, presenting current news and crystallographic research. , The latest ...
(Date:8/21/2020)... ... 2020 , ... NDA Partners Chairman Carl Peck, MD ... expertise in clinical trial planning and feasibility, regulatory inspection readiness, and clinical investigator ... career, Mr. Movahhed has helped design and manage oncology, neurology, cardiovascular, and anti-infective ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... August 13, 2020 , ... True Terpenes , the ... its Scientific Advisory Board (SAB) to research the medical potential of terpenes and the ... when combined with terpenes. The board is focused on expanding the recently launched line ...
(Date:8/12/2020)... (PRWEB) , ... August 12, 2020 , ... ... Inc. (EMMA International), a global leader in FDA compliance consulting has been ... nation’s fastest-growing private companies. The list represents a unique look at the most ...
(Date:7/31/2020)... ... ... R3 Stem Cell International is now offering patients the opportunity to receive four ... may choose which extremities they would like treated. , Several studies have shown just ... R3 International, umbilical cord tissue is obtained from a lab with a long history ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas Medicine, ... provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, cell ... into a strategic partnership whereby Catalent will provide support for the development, manufacturing, ...
Breaking Biology Technology:
Cached News: