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A little stress may be good for you

stress enhances protein damage. If misfolded or damaged proteins accumulate beyond a certain critical point, neurodegenerative diseases such as Huntington's, Parkinson's, Alzheimer's and Lou Gehrig's diseases can result.

Morimoto and Morley studied C. elegans, a transparent roundworm whose biochemical environment is similar to that of human beings and whose genome, or complete genetic sequence, is known. In their experiments, the researchers found that when heat shock factor, the master gene that controls the expression of all chaperones, was underexpressed in adult animals, longevity was suppressed. When heat shock factor was overexpressed, lifespan increased. The results suggest that heat shock factor has significant beneficial effects to the organism as a whole.

"The heat shock response is identical in all life on Earth," said Morimoto, who was the first to clone a human heat shock gene in 1985.


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Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
10-Dec-2003


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