HOME >> BIOLOGY >> NEWS
A molecule family hinders spinal cord regeneration, UF brain institute team finds

GAINESVILLE---Nerve tissue transplants are among the promising experimental therapies to restore communication among cells in injured spinal cords, but scientists long have wondered why the transplanted cells don't grow more vigorously, thereby enhancing the level of recovery.

Now experiments in rats at the University of Florida Brain Institute suggest a possible explanation and a potential target for therapeutic intervention: Researchers suspect that in the days following a transplant, a particular family of molecules forms a barrier that prevents many nerve fiber connections from growing.

The molecules, chondroitin sulfate proteoglycans, or CSPGs, consist of a protein core surrounded by sugars arranged like bristles on a bottle brush; they occur naturally throughout the body. During development, CSPGs are thought to play a vital role by forming boundaries that guide migrating cells to appropriate destinations.

But following an injury, their levels increase so substantially that their growth-regulating function appears to contribute to a failure of the nerve cells to regenerate, according to research published in this month's issue of the journal Experimental Neurology.

The new study expands on previous research indicating increased levels of CSPGs following head and spinal cord injury. Unlike earlier research, however, the UF experiments involved animals with compression-type injuries, which are considered to closely mimic the damage typically experienced by people.

The UF experiments also were the first to look at CSPG expression in cellular transplants.

"We were very surprised to see that the CSPGs increased rapidly, not only in the host around the transplant, but in the transplanted tissue itself," said Dena R. Howland, a research assistant professor of neuroscience in UF's College of medicine and one of the paper's authors. "This increase appears to create a wall of molecules known to be associated with limiting growth.


'"/>

Contact: Victoria White
vickiwhite@xtalwind.net
352-344-2738
University of Florida
21-Nov-1999


Page: 1 2 3

Related biology news :

1. Small, Smac-like molecule encourages death of cancer cells
2. Tiny molecules have big potential as cancer drugs, Stanford researcher believes
3. Synthesized molecules studied as weapon to stop cell division in cancer cells
4. Scientists reinvent DNA as template to produce organic molecules
5. Sweet success in targeting sugar molecules to cells in living animals
6. Emory researchers map structure of anti-cancer molecule
7. UC Riverside researcher takes snapshots of the movement of molecules in a billionth of a second
8. Scientists pinpoint molecules that generate synapses
9. Basic RNA enzyme research promises single-molecule biosensors
10. Joslin researchers identify key molecule in Type 1 diabetes progression
11. Stem cells more vulnerable to toxic chemotherapy when protective molecule is disabled

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/18/2018)... ... 18, 2018 , ... CP Merritt is a national champion Arabian horse that ... however in 2006, he had a medical setback that caused him to limp at ... from cartilage degeneration in his right rear fetlock. Such an injury could be ...
(Date:12/13/2018)... ... December 12, 2018 , ... Illumina, Kaiser Permanente, ResMed and ... The San Diego-based team-building and cooking events company has hosted an impressive guest ... cooking challenges. , Each group who visits receives a completely customized experience, ...
(Date:12/6/2018)... ... December 06, 2018 , ... Stewart has been ... contract services, throughout his career. During his recent five-year tenure with InSphero he ... established the commercial laboratory operations in Brunswick, Maine. Through these experiences, Stewart has ...
Breaking Biology News(10 mins):
(Date:1/8/2019)... ... ... The American Society of Gene and Cell Therapy’s (ASGCT) first class ... of industry leaders identified by the ASGCT board of directors. In total, the Society ... ASGCT members designing transformative pilot studies in gene and cell therapy as they prepare ...
(Date:1/4/2019)... ... January 02, 2019 , ... ... detect precancer and cancer cells in blood, has been named as a partner ... global biotech company developing cell therapies for cancer treatment, will use CellMax Life’s ...
(Date:12/19/2018)... ... 2018 , ... RURO, Inc., a leading provider of information ... The new release enhances the latest version of Limfinity®, RURO’s software framework, and ... , Validation protocols, and their execution, are critical for software systems scrutinized by ...
(Date:12/14/2018)... ... 2018 , ... NOVA OCULUS PARTNERS, LLC, and its Canadian ... immediately begin a clinical patient trial in Edmonton using their pioneering technology for ... has granted what is called an Investigational Testing Authorization for the trial, while ...
Breaking Biology Technology:
Cached News: