HOME >> BIOLOGY >> NEWS
A new Twist on bone development

A new research study reveals that formation of the cells that build bone tissue, called osteoblasts, is suppressed by a complicated inhibitory signal and that formation of the skeleton proceeds only after relief of the inhibition. This inhibitory signal is part of normal development, and without it, bone formation proceeds prematurely and abnormally.

A gene called Runx2 is the earliest and most specific indicator of osteoblast formation. However, Runx2 expression precedes the actual appearance of osteoblasts by about 4 days. Dr. Gerard Karsenty from Baylor College of Medicine in Houston, Texas, and colleagues were interested in determining what other regulatory molecules may be involved in this process during the delay period. They focused on proteins called Twist-1 and Twist-2 that are present in decreased amounts in people with Saethre-Chotzen syndrome, a disease characterized by overproduction of bone tissue. The researchers discovered that Twist proteins are found in Runx2-containing cells very early in development and that osteoblast development occurs only after Twist amounts decrease. Further, without Twist proteins, osteoblasts form too early and too much Twist inhibits osteoblast formation but does not influence that amount of Runx2 expression.

The researchers conclude that Twist proteins transiently inhibit osteoblast differentiation during formation of the skeleton by negatively regulating Runx2. According to Dr. Karsenty, "These results reveal an unanticipated complexity in osteoblast differentiation whose initiation is determined by the relief of an inhibition." The researchers went on to identify a novel region of the Twist proteins, named the Twist box, and characterized this region as the specific site required for interaction between the two Twist proteins and Runx2. The authors point out that some Saethre-Chotzen patients have a mutation that results in a loss of the Twist box and that this mutation could easily explain the occurre
'"/>

Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
15-Mar-2004


Page: 1 2

Related biology news :

1. DoubleTwist completes the first annotation of the human genome
2. New Study Offers A Twist On Evolution Of Animal Postures
3. New Twist In Proteins Offers Possible Route To Improved Antibiotics
4. Bronfenbrenner book sums up human development
5. OutFoxed! New research may redefine late-stage cardiac development
6. Disease diagnosis, drug development focus of UH profs biochip research
7. Jefferson Lab detector technology aids development of cystic fibrosis therapy
8. Joslin Diabetes Center launches research section on developmental and stem cell biology
9. LBP-1a gene mutation linked to disruption of normal fetal development
10. Method to visualize gene activity may provide insight into normal development & genome function
11. Wheelchairs biomechanics, prosthetic development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... , ... Regenative Labs has received approval from the Centers for Medicare & ... first Wharton’s jelly allografts to be assigned a Q code and be approved for ... Wharton’s jelly allograft product to be recognized as a 361 HCT/P by CMS regulated ...
(Date:7/18/2020)... ... July 16, 2020 , ... A study has been published ... Neoasis™ active noise control device to attenuate typical noises in a simulated neonatal ... the alarm sounds from patient monitors, ventilators and other bedside devices that would ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio Inc. http://www.altrubio.com ... a biologic for the treatment of steroid-refractory acute graft-versus-host disease (SR-aGVHD), at European ... J Martin of the Fred Hutchinson Cancer Research Center, this single-arm, open-label Phase ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... FARMS, Mich. (PRWEB) , ... August 12, 2020 ... ... Consulting Group, Inc. (EMMA International), a global leader in FDA compliance consulting ... of the nation’s fastest-growing private companies. The list represents a unique look at ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... collection, today announced Jim Corrigan, President and CEO has been named one of ... broad cross-section of industry sectors, PharmaVoice 100 honorees are selected based on how ...
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is ... $3950. With 50 million stem cells total, patients may choose which extremities they would ... for arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is ...
(Date:7/31/2020)... ... July 29, 2020 , ... ... transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and magnetrons. ... drive one or two switches in a push-pull configuration; yielding fast fall time ...
Breaking Biology Technology:
Cached News: