A new way to engineer cells: The Staudinge...( ction based on a biological mandate: th...)

ction based on a biological mandate: that the new markers and reagents must be abiotic and harmless to the cells," Bertozzi says. Treated cells cultured for several days showed no change in growth rate, indicating that neither the artificial sugars nor the attachment of the probes affected cell viability.

Because the "Staudinger ligation," named by Bertozzi after the classic reaction that inspired it, is potentially useful for labeling components of the cell interior -- such as amino acids from which proteins are assembled -- previously unobservable interactions in the cell may become accessible. "This gives us a new avenue for engineering cell chemistry. The cell is now less of a black box."

"Cell Surface Engineering By a Modified Staundinger Reaction," by Eliana Saxon and Carolyn R. Bertozzi, appears in the 17 March 2000 issue of the journal Science.

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Contact: Paul Preuss
paul_preuss@lbl.gov
510-486-6249
DOE/Lawrence Berkeley National Laboratory
15-Mar-2000

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