The Latest Biology News And Medical NewsBiology News 2Health News 2Biology News 3Health News 3
HOME >> BIOLOGY >> NEWS
A new way to see DNA (and other tiny molecules)

ANAHEIM, Calif.--Like many objects of curiosity in the nanoworld, the DNA molecule has defied visual scrutiny because it lies beyond the "diffraction limit"--a 200 nanometer cutoff where the too-tiny escapes resolution by an optical microscope.

Dehong Hu and Peter Lu, scientists at the Department of Energy's Pacific Northwest National Laboratory in Richland, Wash., report today here at the American Chemical Society's national meeting that they have found their away around this barrier, combining FLIM, or fluorescence lifetime imaging microscopy, with AFM, atomic force microscopy.

A blurry, pixilated FLIM image shows a cluster of florescence-tagged DNA molecules about one micrometer long. When FLIM is combined with an AFM technique that employs a gold-tipped silicon wand that can probe a sample without harming it, the molecule's structure is revealed.

The gold tip, Hu explains, generates a strong electrical field when illuminated by a laser; the electric field's interaction with the fluorescing molecules in the sample provides the image with its contrast.

Hu and Lu have also produced sharp images of fluorescing nanobeads, 40 nanometers diameter.


'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
31-Mar-2004


Page: 1

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. New hydrothermal vents discovered as South Pacific Odyssey research begins
3. Posters highlight water, energy and other natural resource research
4. Joslin Diabetes Center honors brothers living 70-plus years with type 1 diabetes
5. K-State, other universities to study how climate affects plant evolution
6. The search for a kinder, gentler chemotherapy
7. Green tea research leads to gum and other products
8. New survey reveals insights into unique relationship between mothers and pediatricians
9. Manatee population rising in some regions, likely stalled or declining in others
10. Study shows impact of emotionally healthy fathers when mothers poor mental health affects children
11. Another key for the p53 door

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: new way see DNA and other tiny molecules

(Date:11/23/2009)...HAM, Ala. A new study by University of Alabama at... index (BMI) and co-existing medical conditions (c... observed among African-Americans compared to Cauc...blished online Nov. 23 in Cancer , a journal of t...tes that although BMI and co-morbidity are indepen...
(Date:11/23/2009)...like frogs and toads have existed for 360 million ...a new aquatic fungus is threatening to make many o...ember issue of Microbiology Today . , The fung...nd to be associated with waves of amphibian extinc...ia in the 1990,s. Bd infects over 350 amphibian sp...
(Date:11/23/2009)...ts have revealed how environmental irritants such ...to cough, in research published today in the Amer...cine . The authors of the study, from Imperial Col...ified the reaction inside the lungs that can trigg... irritants in the air. They suggest that their fin...
Breaking Biology News(10 mins):Racial disparity in colon cancer survival not easily explained, UAB researchers say 2Research reveals exactly how coughing is triggered by environmental irritants 2Single thawed embryo transfer after PGD does not affect pregnancy rates 9062 1Single thawed embryo transfer after PGD does not affect pregnancy rates 9062 2Single thawed embryo transfer after PGD does not affect pregnancy rates 9062 3Amira Pharmaceuticals Announces Initial Positive Phase 1 Clinical Data for AM211 a Novel Product Candidate for the Treatment of Respiratory Diseases 50392 1Amira Pharmaceuticals Announces Initial Positive Phase 1 Clinical Data for AM211 a Novel Product Candidate for the Treatment of Respiratory Diseases 50392 2The Female Health Company Added to Russell 2000 28R 29 Index 50388 1The Female Health Company Added to Russell 2000 28R 29 Index 50388 2The Female Health Company Added to Russell 2000 28R 29 Index 50388 3
(Date:11/24/2009)...nd,November24/PRNewswire-FirstCall/--deCODE,geneti...llofits,"firstday"motionsbytheU.S.BankruptcyCourtf...ODElastweekfiledavoluntarypetitionfor,reliefunderC...kruptcyCourt. , TheordersissuedbytheBankruptc...ssduringtheChapter11proceedings.Inparticular,the,c...
(Date:11/24/2009)... The FBI recently approved the Promega PowerPlex...g in or generating DNA records for the National DN..., WI USA (PRWEB) -- The FBI recently approved the ...aboratories participating in, or generating DNA re...DIS currently contains more than seven million pro...
(Date:11/24/2009)...if.,Nov.24/PRNewswire-FirstCall/--GenomicHealth,In...micHealth,sExecutiveChairman,willpresentatthe21stA...onTuesday,December1,2009at10:00a.m.ET. ,, Toacc...ntation,visittheInvestorRelationssectionofGenomicH... .Pleaseconnecttothewebsiteatleast15minutespriorto...
(Date:11/23/2009)... 23, 2009 In a provocative new study, a Universit...ide emissions the major cause of global warming ...llapses or society builds the equivalent of one ne...ikely that there will be any substantial near-term...carbon dioxide emission rates," says the new paper...
Breaking Biology Technology:deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 2deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 3NDIS Approval of Promega PowerPlex Kit Clears Path for More DNA Profiles to be Added to U.S. Database 2Genomic Health to Present at Piper Jaffray Health Care Conference 2Is global warming unstoppable? 2Is global warming unstoppable? 3Is global warming unstoppable? 4
Other News:
...Sexually active college-age women have a high incidence of human papillomavirus...(HPV) infection according to a study supported by the National Institute of...Allergy and Infectious Disease (NIAID
...ed new compounds that show promise in...treating m...elf-destruct.......A scientific paper about the co... Journal of Medicinal Chemistry, published by the....me, about 300 million people suffer from malaria,....
...rsity of California, Davis, have demonstrated for ... when their internal defense systems...are "jump s... major damage from...later pests.......These induc...he plant kingdom...and are being studied to demons...
...r Mapping to Hammer Awards and AAAS Fellowships......S: ...2:30 p.m. FRIDAY, FEBRUARY 13...AAAS Press R...adford Butman, USGS oceanographer...at the Woods H...t...Predicting the Fate of Contaminants in the New...
Sexually Active Younger Women Are At Higher Risk For Infection With Human Papillomavirus 2Sexually Active Younger Women Are At Higher Risk For Infection With Human Papillomavirus 3Johns Hopkins Scientists Designing Compounds To Fight Malaria 2Johns Hopkins Scientists Designing Compounds To Fight Malaria 3Plants Thrive With Insect-Induced Immune Responses 2Plants Thrive With Insect-Induced Immune Responses 3Summary Of USGS Presentations And Activities, AAAS, 1998 2Summary Of USGS Presentations And Activities, AAAS, 1998 3
Researchers at Columbia University Medical Center have discovered a way to overcome one of the major hurdles in gene therapy for cancer: its tendency to kill normal cells in the process of eradicating
...ARL) at the University of Arizona today announced ...h (SUR) grant of a storage infrastructure that wil... manage vast amounts of biological data......."It ...lementing leading-edge technology," said Michael C...
...y with several members affected by a type of heart...Mayo Clinic team found a defect in a gene on chrom...tients with DCM, they found four additional mutati...es the sodium ion channel in the heart, which help...
...tal to our interactions with other human beings. A...meone straight in the eye, at other times we decid...e isn't straightforward, and we have to select bet...ice, we might subsequently change our mind and sel...
Columbia research lifts major hurdle to gene therapy for cancer 2University of Arizona receives IBM grant for massive virtual storage system for life sciences data 2University of Arizona receives IBM grant for massive virtual storage system for life sciences data 3Mayo Clinic researchers discover new kind of heart failure gene 2Choosing where to look and changing your mind 2