HOME >> BIOLOGY >> NEWS
A new way to see DNA (and other tiny molecules)

ANAHEIM, Calif.--Like many objects of curiosity in the nanoworld, the DNA molecule has defied visual scrutiny because it lies beyond the "diffraction limit"--a 200 nanometer cutoff where the too-tiny escapes resolution by an optical microscope.

Dehong Hu and Peter Lu, scientists at the Department of Energy's Pacific Northwest National Laboratory in Richland, Wash., report today here at the American Chemical Society's national meeting that they have found their away around this barrier, combining FLIM, or fluorescence lifetime imaging microscopy, with AFM, atomic force microscopy.

A blurry, pixilated FLIM image shows a cluster of florescence-tagged DNA molecules about one micrometer long. When FLIM is combined with an AFM technique that employs a gold-tipped silicon wand that can probe a sample without harming it, the molecule's structure is revealed.

The gold tip, Hu explains, generates a strong electrical field when illuminated by a laser; the electric field's interaction with the fluorescing molecules in the sample provides the image with its contrast.

Hu and Lu have also produced sharp images of fluorescing nanobeads, 40 nanometers diameter.


'"/>

Contact: Bill Cannon
cannon@pnl.gov
509-375-3732
DOE/Pacific Northwest National Laboratory
31-Mar-2004


Page: 1

Related biology news :

1. New molecular link key to cellular proteins involved in cancer progression, other diseases
2. New hydrothermal vents discovered as South Pacific Odyssey research begins
3. Posters highlight water, energy and other natural resource research
4. Joslin Diabetes Center honors brothers living 70-plus years with type 1 diabetes
5. K-State, other universities to study how climate affects plant evolution
6. The search for a kinder, gentler chemotherapy
7. Green tea research leads to gum and other products
8. New survey reveals insights into unique relationship between mothers and pediatricians
9. Manatee population rising in some regions, likely stalled or declining in others
10. Study shows impact of emotionally healthy fathers when mothers poor mental health affects children
11. Another key for the p53 door

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... Carterra® ... they have opened a Customer Experience Center (CEC) and office in Munich, Germany. ... office. , The Munich CEC will be a place for researchers throughout Europe ...
(Date:8/14/2019)... ... August 13, 2019 , ... ... of Molecular Pathology, Institute of Cancer Research (ICR) in a live webinar ... about the process of biomarker and companion diagnostic development including machine learning approaches ...
(Date:8/6/2019)... ... August 06, 2019 , ... VetStem ... clinical, regulatory and GMP manufacturing experience. In November it spun out a ... extensive regulatory experience and one of the first cGMP cell manufacturing facilities ...
Breaking Biology News(10 mins):
(Date:8/23/2019)... ... August 22, 2019 , ... An upcoming ... is scheduled to broadcast 4Q/2019. Check your local listings for more information. , ... generic drug delivery. Focusing on therapeutics for children and the elderly, viewers will ...
(Date:8/7/2019)... Ohio (PRWEB) , ... August 07, 2019 , ... Locus ... a breakthrough line of soil amendments (soil “probiotics”), including Rhizolizer ® , which ... a year—the largest impact any approach has offered to date. Results from the treatment ...
(Date:8/4/2019)... MINNEAPOLIS (PRWEB) , ... August 02, 2019 , ... Cirtec ... minimally invasive devices, today announced that it has begun construction on a 30,000 sq. ... about 15 miles from San Jose. , The facility, which is expected to ...
(Date:7/19/2019)... , ... July 18, 2019 , ... ... as “Ravi Everest,” will be joining forces with California-based charity Coalition Duchenne for ... July 20-22nd. Coalition Duchenne raises awareness and funding for Duchenne muscular dystrophy and ...
Breaking Biology Technology:
Cached News: