HOME >> BIOLOGY >> NEWS
A new window to view how experiences rewire the brain

Howard Hughes Medical Institute researchers have developed sophisticated microscopy techniques that permit them to watch how the brains of live mice are rewired as the mice learn to adapt to new experiences.

Their studies show that rewiring of the brain involves the formation and elimination of synapses, the connections between neurons. The technique offers a new way to examine how learning can spur changes in the organization of neuronal connections in the brain.

The researchers, postdoctoral fellow Josh Trachtenberg, graduate student Brian Chen and Karel Svoboda, a Howard Hughes Medical Institute investigator at Cold Spring Harbor Laboratory, published their findings in the December 19/26, 2002,issue of the journal Nature.

According to Svoboda, researchers had previously shown that the adult brain has a capacity to reorganize in response to new experience. However, it is not clear how this reorganization might occur. Svoboda and his colleagues wanted to see whether learning could induce restructuring of the neural circuitry in the brain that could not be picked up with conventional techniques.

To study those kinds of changes in a living animal, Svoboda and his colleagues started with transgenic mice that were engineered to produce green fluorescent protein within neurons in a portion of the brain that processes tactile sensory inputs from the whiskers. To observe changes in these neurons at high resolution, the scientists constructed a 2-photon laser scanning microscope. This microscope uses an infrared laser to excite green fluorescent protein in neurons, deep in the brain, through a tiny glass window installed in a portion of the mouse's skull.

"Since we had this great tool to look at the brain at unprecedented resolution we did not know what to expect and we began with no preconceived notions of what we might see in these animals," said Svoboda. "
'"/>

Contact: Jim Keeley
keeleyj@hhmi.org
301-215-8858
Howard Hughes Medical Institute
18-Dec-2002


Page: 1 2 3 4

Related biology news :

1. Study by Tufts biologist provides window into progression of some degenerative diseases
2. Film found on windows after 9/11 reveals higher level of pollutants
3. Germ-free transparent fish open new window into gut development
4. Yeast mutations offer window into human disease
5. New findings are a window into the late stages of Lou Gehrigs disease
6. Transparent fish provide window on blood formation and marrow transplantation
7. Bugs from the deep may be window into the origins of life -- on earth and beyond
8. Fertility study shows increased estrogen shortens window of implantation in mice
9. Novel gene mutation causes Huntingtons-like symptoms, providing window into how brain cells die
10. Turning off building lights reduces bird window-kill by 83%
11. Stanfords new antigen microarrays open window to better disease screening

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/24/2017)... , Mar 24, 2017 Research and Markets ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 15.1% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
(Date:3/22/2017)... , March 21, 2017 ... Cloud used by retailers such as 1-800-Flowers and ... platform — Product Recommendations and Replenishment. Using Optimove,s machine ... more personalized product and replenishment recommendations to their ... also on predictions of customer intent drawn from ...
Breaking Biology News(10 mins):
(Date:8/15/2017)... ... August 15, 2017 , ... Pittcon is pleased to ... and scientific instruments. This year’s symposium, organized by the Pittcon 2018 program chair, ... Bioanalytical Applications.” This dynamic presentation will discuss novel ionization processes, high throughput IMS-MS ...
(Date:8/15/2017)... , ... August 15, 2017 , ... ... shopping cart. Now mobile responsive, the new website makes it easy to navigate ... in between. Users can now find detailed product information, educational industry content and ...
(Date:8/11/2017)... , ... August 11, 2017 , ... A staple in ... this month that will incorporate important key elements including a new digital marketing strategy ... that has supported them, Bill Miller has partnered with the South Texas Blood & ...
(Date:8/10/2017)... Linda, Ca (PRWEB) , ... August 09, 2017 ... ... exosomes for regenerative medicine applications in the clinic is here. The team at ... EVs present in conditioned medium for clinical studies. , Dr. Travis Antes, ...
Breaking Biology Technology:
Cached News: