HOME >> BIOLOGY >> NEWS
A paradox helps explain how aspirin works

Even though aspirin's pain-killing capacity was well known to Hippocrates in the fifth century B.C., exactly what it does remains somewhat of a mystery. Now, Johns Hopkins researchers have shown that aspirin inhibits interleukin-4, a protein involved in allergic reactions and inflammation.

"The finding appears to explain some of aspirin's less obvious beneficial effects, such as how the drug might help prevent heart disease or the ravages of rheumatoid arthritis," says Vincenzo Casolaro, M.D., Ph.D., assistant professor of clinical immunology at Hopkins, reporting in the March issue of Blood.

Aspirin, the world's most used non-steroidal anti-inflammatory drug, provides the mainstay of therapy for inflammatory musculoskeletal disorders and has been shown to be effective in the management and prevention of a wide variety of non-inflammatory conditions, including coronary and cerebral ischemia and possibly gastrointestinal cancer.

Since the 1970s, researchers have known that aspirin works, in part, by inhibiting prostaglandin, a hormone-like substance present in a variety of tissues and body fluids that has many roles, including causing contraction of smooth muscle and promoting inflammation. Specifically, aspirin inhibits an enzyme, cyclo-oxygenase (COX), that catalyzes the generation of prostaglandin from cell membrane fatty acid precursors. But the suppression of prostaglandin production could not fully account for aspirin's effectiveness because, after 15 minutes, aspirin is broken down in the body and becomes salicylic acid, a completely ineffective inhibitor of COX.

By 1994, aspirin was found to actually repress the activation of NF-ΚB, a molecular activator of cytokines, chemicals that trigger inflammation. Casolaro, an allergy researcher, wondered whether IL-4, a cytokine, was in this category. His tests showed that IL-4 was not, however, and, in fact, that NF-ΚB repressed IL-4 expression in immune system cell
'"/>

Contact: Kate O'Rourke
korourke@jhmi.edu
410-955-8665
Johns Hopkins Medical Institutions
4-Mar-2001


Page: 1 2

Related biology news :

1. Smaller food portions may explain the French paradox of rich foods and a svelte population
2. A seafood paradox: Will fish farming save or deplete our ocean fisheries?
3. Beyond the French paradox
4. One theory solves two ancient climate paradoxes
5. Atacama rover helps NASA learn to search for life on Mars
6. Reducing allergens in the home helps inner-city children with asthma
7. As informatics grows, Indiana University helps set research agenda
8. New diagnostic technology helps justify earlier cataract surgery
9. New technique helps scientists reveal interactions between genes and drugs
10. Living at home helps young mothers stay in school
11. Hormone helps fish to mate, may affect human hearing

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... ... July 03, 2020 , ... ... earn outstanding recognition and multiple awards for not only the products and treatments ... SoME® Skincare and Vivace® Microneedle RF. All the brands built by ABM have ...
(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a registered ... common and aggressive adult brain cancer—announced today the appointments of its first Senior ... with supporting the organization’s initiatives and overall vision. , "Senior Fellows are more ...
(Date:6/23/2020)... ... June 23, 2020 , ... ... monoclonal antibody development services, today announced that the company has received ISO9001:2015 ... the pharmaceutical, diagnostics, and research industries. The decision to pursue ISO9001 accreditation ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... , ... Join experts from Reed Tech , Gary Saner, Sr. Manager, ... hour live webinar on Thursday, August 13, 2020 at 11am EDT (4pm ... devices. Specifically, for medical devices, the NMPA has departments dealing with medical device registration ...
(Date:7/18/2020)... ... July 17, 2020 , ... dicentra , a leading ... food industries, is pleased to announce that Charles Galea has joined its clinical ... Charles is an accomplished and results-driven sales executive with over 10 years of ...
(Date:7/10/2020)... ... 2020 , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company ... Nissenson, M.D., F.A.C.P., as its Chief Medical Officer. Dr. Nissenson will join ... Dr. Nissenson serves as an Emeritus Professor of Medicine at the David ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... competitively procured purchasing contracts to its membership, recently named BioFit Engineered Products ... with the opportunity to purchase ergonomic seating, cafeteria tables, book trucks and carts ...
Breaking Biology Technology:
Cached News: