HOME >> BIOLOGY >> NEWS
A pathway towards cures for Parkinson's and cancer

Researchers studying the Hedgehog signaling pathway have identified small molecules that could form the foundations of exciting new treatments for Parkinson's disease and certain cancers.

New research published in Journal of Biology - the open access journal for exceptional research - has identified small molecules that are able to stimulate or block the Hedgehog signalling pathway, which is essential to the development, maintenance and repair of cells in the human body. The potential of these molecules to be used as drugs to treat both degenerative diseases and cancer is exciting as their small size may allow these molecules to enter all parts of the body and cross the blood brain barrier, eliminating the need for injections of therapeutics directly into the target site.

The Hedgehog signaling pathway is crucial to the development of healthy animals as well as the maintenance and repair of adult cells. Hedgehog genes were first identified in the fruitfly, and were so called because fly embryos with a defect in this gene were covered in bristles. The central role of the Hedgehog signalling pathway in the regulation of the growth and division of specific types of cells makes it of great interest to researchers investigating diseases like Parkinson's that are characterised by a lack of particular cells as the central nervous system degenerates. Finding drugs that can stimulate the Hedgehog signaling pathway and lead to the production of new cells could potentially cure this disease. It is also hoped that by developing drugs that block the Hedgehog signalling pathway researchers will be able to induce the regression of tumours in patients with certain cancers that depend on this pathway (specifically, basal cell carcinoma and medulloblastoma).

Recent research has shown the Hedgehog protein can itself reduce the behavioural impairments and neuronal loss that occur in animal models of the Parkinson's disease suggesting that manipulating th
'"/>

Contact: Gordon Fletcher
gordon@biomedcentral.com
44-207-323-0323
BioMed Central
6-Nov-2002


Page: 1 2

Related biology news :

1. Serotonin metabolites in mollusks suggest pathways for human therapies
2. Penn scientists identify novel pathway in aneurysms
3. Marijuana ingredient inhibits VEGF pathway required for brain tumor blood vessels
4. Activated signaling pathway may predict lung cancer patients response to gefitinib
5. A pathway to blocking autoimmunity
6. UNC scientists discover molecular pathway leading to nerve growth and regeneration
7. From lung to gut the Wnt signaling pathway transforms cell fate
8. Cell growth and death controlled by single pathway in lymphoma cancer model
9. PTC Therapeutics researchers identify biochemical pathway important for modulating cell growth
10. Lock to food-borne pathogen pathway may be key to vaccine
11. Researchers uncover pathway that could lead to plant generation of human-like protein

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... Fla. (PRWEB) , ... January 31, 2019 , ... ... Annual SCOPE Summit , geared toward clinical operations executives and focusing on all ... the importance of effective project management, portfolio management, resource management, patient engagement, and ...
(Date:1/25/2019)... (PRWEB) , ... January 24, 2019 , ... ... Dr. Julia Oh, PhD, Assistant Professor of Microbiology at the Jackson Laboratory (JAX), ... from around the world, Dr. Oh will bring to uBiome expertise in skin ...
(Date:1/20/2019)... WHITEHOUSE, N.J. (PRWEB) , ... January 16, 2019 , ... ... their service offering through the introduction of its own liver 3D cell culture models. ... all of its models, protocols and validation criteria so that any researcher can replicate ...
Breaking Biology News(10 mins):
(Date:2/14/2019)... ... February 14, 2019 , ... Leak Detection Associates ... the pharmaceutical, biotechnology and food industries, formally announced today the appointment of two ... has been named Chief Executive Officer and will oversee all aspects of the ...
(Date:2/2/2019)... ... 2019 , ... Signature Matrix and Signature Cord are the ... stem cell research expert and Amazon best-selling author, Neil Riordan, PA, PhD, and ... tissue allograft that originates from the same tissue used to manufacture the purified, ...
(Date:1/30/2019)... (PRWEB) , ... January 29, 2019 , ... ... Inc. (AskBio), today announced the dosing of the first patient in a phase ... is a serious disease associated with high morbidity and often leads to premature ...
(Date:1/30/2019)... ... January 30, 2019 , ... In 2016, Veronafiere ... to promote and give recognition to producers whose work focuses entirely on natural, ... place in Verona, Italy, contemporaneously to the 5StarWines blind tasting organized from April ...
Breaking Biology Technology:
Cached News: