The atrial natriuretic peptide (ANP) influences the tone and caliber of blood vessels and has a potential role in modulating volume homeostasis, i.e. the state of equilibrium in the body with respect to various functions and to the chemical compositions of the fluids and tissues. ANP is secreted by atrial myocytes as a 126 aminoacid molecule and divided into different fragments, namely proANP(1-30) (NtANP), proANP(31-67) (mdANP), proANP(79-98) and the active ANP(99-126).
Similar properties have been reported in previous research studies for ANP and proANP-(1-30). A University of South Florida research finding demonstrated that plasma ANP levels in gynecologic cancer patients were significantly higher than those in healthy, non-pregnant women. Now, physiologists from the same institution have attempted to extend their original observations on ANP in gynecologic malignancy, in particular to examine the possible relationship between ANP and proANP-(1-30) levels in plasma and ascites fluid (serous fluid from the peritoneal cacity) in primary cancer of the ovaries.
The authors of a new study entitled, Atrial Natriuretic Peptide (ANP) and proANP-(1-30) levels in Gynecologic Malignancy," are Papineni S. Rao, PhD, Richard J. Cardosi, MD, John R. Dietz, PhD, James V. Fiorica, MD, Edward C. Grendys, jr, MD, and Mitchel S. Hoffman, MD, from the Departments of Obstetrics & Gynecology and Physiology & Bi
Contact: Donna Krupa
American Physiological Society