HOME >> BIOLOGY >> NEWS
A pregnant pause for unexpected interactions

Approximately 1-3% of all couples experience recurrent pregnancy loss, and about 5070% of all conceptions fail. The underlying molecular mechanisms causing these heartbreaking conditions, however, remain unknown. Many cases of pregnancy loss are known to due to damage to the fetus through genetic, anatomic, endocrine, or Infectious means.

When such causes are ruled out, the other source is thought to be caused by a maternal immune response. Most of the research in this arena has focused on identifying reactions at the maternal-fetal interface in the placenta. Adrian Erlebacher and colleagues, from Harvard School of Public Health, have now, however, identified new means by which maternal immune activation can lead to pregnancy failure. Here, the authors provide a mouse model of early pregnancy loss and present data that unexpectedly links the reproductive hormone secretion system to the immune system.

The mouse model shows that when a specific immune cell receptor called CD40 is activated early in pregnancy the resulting inflammatory response caused embryo resorption. The researchers traced the molecular mechanisms underlying this process, and found that the loss of the embryo was not due to fetal damage or activity at the fetal-maternal interface, but rather because the inflammatory response ultimately caused a decrease in progesterone, the hormone responsible for preparing the body for pregnancy and maintaining it until birth.

These data make it clear that the immune system, by interfering with the reproductive hormones, may contribute to human infertility, especially in cases of recurrent pregnancy loss. Further the finding that there is a link between the immune system and the reproductive hormone secretion may provide a new means of therapy for women who suffer such repeated and early pregnancy loss by targeting the mediators of such inflammatory responses.


'"/>

Contact: Laurie Goodman
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
1-Jul-2004


Page: 1

Related biology news :

1. Alcohol-use and depression among pregnant and postpartum women
2. Gestational diabetes not found to alter the metabolic processes in obese pregnant women
3. Common nutrients fed to pregnant mice altered their offsprings coat color
4. Doctors miss chances to help pregnant women quit smoking
5. Many pregnant women may have depression, but few getting treatment, study finds
6. Study finds more than 1 in 10 pregnant women drink alcohol
7. Labor-inducing folklore alive and well among pregnant women
8. Women who drink moderately do not face a longer wait to become pregnant
9. A combination of zinc and vitamin A may restore night vision in pregnant Nepalese women
10. New research shows calcium deficiency permits faster lead release from pregnant womens bones
11. Ginger may spice up the lives of pregnant women

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/25/2020)... ... May 22, 2020 , ... Oxford Nanopore Technologies is in advanced development ... virus that causes COVID-19. , The LamPORE assay is designed to be ... to very large numbers of samples. Hardware and reagents sit outside current, squeezed ...
(Date:5/21/2020)... N.C. (PRWEB) , ... May ... ... , the leading software-as-a-service (SaaS) provider of operations management solutions, today introduced ... BioMed module provides a cloud-based platform for connecting the people and systems ...
(Date:5/21/2020)... ... May 20, 2020 , ... Law Enforcement has always been a highly stressful ... The positions of these men and women put them constantly in harm’s way both ... precisely. Officers have always had to face very high daily stress. Now, COVID-19 introduces ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... ... June 26, 2020 , ... ... solutions providers, today announced its strong opposition to the recently introduced bicameral ... a blanket ban on most federal use of nearly all biometric and related ...
(Date:6/23/2020)... ... 22, 2020 , ... Dracen Pharmaceuticals Inc., announced today that ... during the American Association for Cancer Research Virtual meeting. One poster describes the ... single agent activity in KEAP1 mutant tumor models of NSCLC. , ...
(Date:6/11/2020)... (PRWEB) , ... June 09, 2020 , ... ... of Phase I of a Small Business Innovation Research (SBIR) program funded by ... 21st Century: Rapid Toxin Detection in the Field”. The project’s goal was to ...
(Date:6/2/2020)... ... June 01, 2020 , ... As part ... positive change in the world, enterprise security solutions provider bitsIO donated time to ... working from home during self-quarantines and shelter-in-place orders, companies are increasingly concerned about ...
Breaking Biology Technology:
Cached News: