HOME >> BIOLOGY >> NEWS
A probable cause for high blood pressure identified - shows links with diabetes

A study published in this week's Proceedings of the National Academy of Sciences identified the molecule that binds to a receptor (a molecule on the cell surface that triggers a reaction within the cell) in the brain that is known to regulate blood pressure and release of insulin. Furthermore, the researchers discovered that this molecule acts as a neurotransmitter, in that it conveys messages throughout different regions of the brain.

"We have known for decades that when a particular receptor in the brain is over-stimulated, blood vessels constrict and blood pressure rises," said George Prell, PhD, Associate Professor of Pharmacology and Biological Chemistry at Mount Sinai School of Medicine and first author on the study. "What we didn't know was which molecule in the body was binding to this receptor to trigger this reaction. Now that we have identified this substance, we can begin to look at ways of blocking its action. We also found that excessive accumulation of this molecule in the pancreas will impair insulin release, thus it is possible that this molecule is the long searched for link between these two disorders."

The researchers found that imidazole-4-acetic acid-ribotide binds to imidazol(in)e receptors which are widespread throughout the brain, and are abundant in the brainstem in areas critical to blood pressure regulation. In addition, they found that when this molecule binds to the receptor it leads to elevated blood pressure. When an antagonist (another molecule that blocks the action of the first) is given, imidazole-4-acetic acid-ribotide's high blood pressure effect is inhibited.

While some causes of high blood pressure are clearly established, the majority of cases are considered "essential hypertension," that is high blood pressure for which the cause is unknown. The researchers hypothesize that elevated levels of this ribotide may account for a major fraction of cases of essential hypertension.

In addition, imida
'"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
13-Sep-2004


Page: 1 2

Related biology news :

1. Rutgers geneticists discover probable causes of hybrid plant vigor
2. Climate change plus human pressure caused large mammal extinctions in late Pleistocene
3. Researchers determine genetic cause of Timothy syndrome
4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
5. Marijuana use could cause tubal pregnancies
6. Pollutant causes delayed flowering in plants
7. Disruption of protein-folding causes neurodegeneration, mental retardation
8. Researchers discover why mutant gene causes colon cancer
9. New genetic hypothesis for the cause of autism
10. Common cold virus can cause polio in mice when injected into muscles
11. Mitochondrial genes cause nuclear mischief

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/13/2018)... Calif. (PRWEB) , ... November 12, 2018 , ... ... offering premier, interactive educational virtual events and webinars, will be hosting its 9th ... 15th, 2018, featuring new technologies and treatments available, and updates in regulatory processes ...
(Date:11/13/2018)... ... November 13, 2018 , ... M3 ... service companies in North America, announces a new partnership with EmergeOrtho, one ... provider of innovative, quality, comprehensive musculoskeletal care. This new joint venture will ...
(Date:11/9/2018)... ... November 09, 2018 , ... Controlled Contamination Services (CCS) ... that will enable CCS to scale its business across the US and widen ... geographic footprint and a need for a wide array of services to accommodate ...
Breaking Biology News(10 mins):
(Date:11/9/2018)... N.H. and PHILADELPHIA (PRWEB) , ... November 08, ... ... 25-year-old control system integrator of custom industrial automation and IT solutions with 140 ... be exhibiting at Automation Fair®, taking place at the Pennsylvania Convention Center on ...
(Date:11/5/2018)... ... 2018 , ... USARAD Holdings Inc., the leading US Joint ... VC firms announces at Distributed Health 2018 conference November 5-6 (Nashville, TN) implementation ... obtaining its first radiology interpretations, one of the first known true use of ...
(Date:10/31/2018)... ... ... Rooam , the premier payment platform for the nightlife and hospitality ... of the Tally payment app, the leading payment platform in Chicago that allows users ... market share and increase the number of restaurant and bar locations offered on its ...
(Date:10/29/2018)... ... October 29, 2018 , ... PracticeMatch , a company that provides ... of physician career fairs planned for 2019. The company has expanded its offering of ... in the areas of the country which have the highest concentrations of resident and ...
Breaking Biology Technology:
Cached News: