HOME >> BIOLOGY >> NEWS
A probable cause for high blood pressure identified - shows links with diabetes

A study published in this week's Proceedings of the National Academy of Sciences identified the molecule that binds to a receptor (a molecule on the cell surface that triggers a reaction within the cell) in the brain that is known to regulate blood pressure and release of insulin. Furthermore, the researchers discovered that this molecule acts as a neurotransmitter, in that it conveys messages throughout different regions of the brain.

"We have known for decades that when a particular receptor in the brain is over-stimulated, blood vessels constrict and blood pressure rises," said George Prell, PhD, Associate Professor of Pharmacology and Biological Chemistry at Mount Sinai School of Medicine and first author on the study. "What we didn't know was which molecule in the body was binding to this receptor to trigger this reaction. Now that we have identified this substance, we can begin to look at ways of blocking its action. We also found that excessive accumulation of this molecule in the pancreas will impair insulin release, thus it is possible that this molecule is the long searched for link between these two disorders."

The researchers found that imidazole-4-acetic acid-ribotide binds to imidazol(in)e receptors which are widespread throughout the brain, and are abundant in the brainstem in areas critical to blood pressure regulation. In addition, they found that when this molecule binds to the receptor it leads to elevated blood pressure. When an antagonist (another molecule that blocks the action of the first) is given, imidazole-4-acetic acid-ribotide's high blood pressure effect is inhibited.

While some causes of high blood pressure are clearly established, the majority of cases are considered "essential hypertension," that is high blood pressure for which the cause is unknown. The researchers hypothesize that elevated levels of this ribotide may account for a major fraction of cases of essential hypertension.

In addition, imida
'"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
13-Sep-2004


Page: 1 2

Related biology news :

1. Rutgers geneticists discover probable causes of hybrid plant vigor
2. Climate change plus human pressure caused large mammal extinctions in late Pleistocene
3. Researchers determine genetic cause of Timothy syndrome
4. Cigarette smoke causes breaks in DNA and defects to a cells chromosomes, Pitt study finds
5. Marijuana use could cause tubal pregnancies
6. Pollutant causes delayed flowering in plants
7. Disruption of protein-folding causes neurodegeneration, mental retardation
8. Researchers discover why mutant gene causes colon cancer
9. New genetic hypothesis for the cause of autism
10. Common cold virus can cause polio in mice when injected into muscles
11. Mitochondrial genes cause nuclear mischief

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: