HOME >> BIOLOGY >> NEWS
A switch that makes a blood clot sticky found within the platelet membrane

(Philadelphia, PA) - Integrin receptors allow cells to attach to other cells and to connective tissue which is necessary to form tissues, organs, or even people, for that matter. Researchers at the University of Pennsylvania School of Medicine have demonstrated that a key to activating αIIbβ3, the integrin that allows platelets to form blood clots, can be found in the part of the molecule embedded within a platelet's outer membrane.

The αIIbβ3 integrin, also known as the platelet fibrinogen receptor or GP IIb-IIIa, has been the focus of an entire class of blood-thinning drugs, called GPIIb-IIIa agonists. The Penn researchers findings, published in this week's issue of Science, have implications for drugs created to thin the blood and, perhaps more broadly, offer an intriguing hint as to how integrins on cells throughout the body may function.

"The part of the GPIIb-IIIa molecule that is embedded in the fatty layers that constitute the platelet's outer membrane can determine whether or not the integrin is activated, thereby making the platelet 'sticky,'" said Joel S. Bennett, MD, Professor in Penn's Division of Hematology/Oncology within the Department of Medicine. "The transmembrane region, which was generally assumed to be just an anchor for keeping the integrin receptor in place, can be an activating switch for the entire molecule."

Once activated, the two subunits of GPIIb-IIIa that extend outside the cell can clasp the walls of a damaged blood vessel or a passing fibrinogen molecule V much like a bobby pin can close around strands of hair V thereby forming a normal blood clot or a pathologic thrombus. GPIIb-IIIa agonist drugs, such as ReoPro, Integrilin, and Aggrastat, work by preventing activated GPIIb-IIIa from binding to other objects in the bloodstream.

Since it is a protein, GPIIb-IIIa is made up of amino acids, strung along in a specific sequence to give the protein its shape. Bennett and his colleagues were able
'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
1-May-2003


Page: 1 2

Related biology news :

1. Researchers find color sensitive atomic switch in bacteria
2. Rice finds on-off switch for buckyball toxicity
3. Plant-like enzyme acts as key life cycle switch in malaria parasite
4. Shared gene switch for all plants found
5. EMBL researchers discover key molecular switch in eye development of medaka fish
6. Genetic master switch sends bacteria toward seafood dinner
7. Scientists switch components in cell circuits: Possible new technology, therapy
8. Crabs switch skeleton types
9. The mechanical switch in the ear
10. The structure behind the switch
11. Oxygen key switch in transforming adult stem cells from fat into cartilage

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/21/2016)... 2016 Unique technology combines ... superior security   Xura, Inc. ... secure digital communications services, today announced it is working ... enterprise customers, particularly those in the Financial Services Sector, ... authentication within a mobile app, alongside, and in combination ...
(Date:3/15/2016)... Yissum Research Development Company of the Hebrew University ... University, announced today the formation of Neteera Technologies ... biological indicators. Neteera Technologies has completed its first round ... Neteera,s ... from sweat ducts, enables reliable and speedy biometric identification, ...
(Date:3/11/2016)... 2016 --> ... "Image Recognition Market by Technology (Pattern Recognition), by Component ... Deployment Type (On-Premises and Cloud), by Industry Vertical and ... MarketsandMarkets, the global market is expected to grow from ... by 2020, at a CAGR of 19.1%. ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... ... 2016 , ... Shimadzu Scientific Instruments (SSI) will be showcasing ... Conference and Expo. Shimadzu’s high-performance instruments enable laboratories to test cannabis products for ... stop by booth 1021 to learn how Shimadzu’s instruments can help improve QA/QC ...
(Date:4/27/2016)... and RESEARCH TRIANGLE PARK, N.C. ... UTHR ) announced today that Martine ... United Therapeutics will provide an overview and update on ... Annual Health Care Conference. The presentation ... 10:00 a.m. Eastern Time, and can be accessed via ...
(Date:4/27/2016)... ... April 27, 2016 , ... ... PET (Positron Emission Tomography) and MRI (Magnetic Resonance Imaging) in existing third-party MRI ... testing novel treatments in small animal subjects. Simultaneous PET/MRI imaging offers a solution ...
(Date:4/27/2016)... April 27, 2016 ReportsnReports.com ... with specific focus on US, EU, ... , to the healthcare business intelligence collection of ... Complete report on the Flow Cytometry market ... supported with 282 tables and figures is now ...
Breaking Biology Technology:
Cached News: