HOME >> BIOLOGY >> NEWS
A switch that makes a blood clot sticky found within the platelet membrane

to determine which amino acids are responsible for activating GPIIb-IIIa by substituting a 'wrong' amino acid at spaces along the  protein chain and expressing the mutant protein in cells growing in culture. They found that the transmembrane portion of one of the GPIIb-IIIa subunits is responsible for responding to activation signals and, in return, causing groups of the activated integrin to cluster.

"Remarkably, these regions are evolutionarily conserved V meaning the transmembrane region in GPIIb-IIIa is the same in apes or rabbits or mice as they are in humans," said Bennett. "That tells us that the sequences of the transmembrane region of integrins are important factors in how these proteins function."

Moreover, nearly every integrin has a different transmembrane region made up of a unique amino acid sequence. If the transmembrane regions of all integrins work on a similar scheme, it would provide a new paradigm for the function of integrins and other cell membrane proteins.

"Integrin receptors are more than just a cellular form of Velcro V as integrins bind, they can also generate signals that command a cell to act, such as whether to divide or differentiate or to produce an important protein such as a gene transcription factor," said Bennett. "It will be interesting, and even medically important, to determine how these signals can be modulated."

Other scientists involved in the research paper described here include Renhao Li, Neal Mitra, Holly Gratkowski, Gaston Vilaire, Reustem Litvinov, Chandrasekaran Nagasami, John Weisel, James D. Lear, and William F. DeGrado from Penn.


'"/>

Contact: Greg Lester
lesterg@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
1-May-2003


Page: 1 2

Related biology news :

1. Researchers find color sensitive atomic switch in bacteria
2. Rice finds on-off switch for buckyball toxicity
3. Plant-like enzyme acts as key life cycle switch in malaria parasite
4. Shared gene switch for all plants found
5. EMBL researchers discover key molecular switch in eye development of medaka fish
6. Genetic master switch sends bacteria toward seafood dinner
7. Scientists switch components in cell circuits: Possible new technology, therapy
8. Crabs switch skeleton types
9. The mechanical switch in the ear
10. The structure behind the switch
11. Oxygen key switch in transforming adult stem cells from fat into cartilage

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... 2017 NXT-ID, Inc. (NASDAQ: NXTD ) ... of its 2016 Annual Report on Form 10-K on Thursday April ... ... in the Investor Relations section of the Company,s website at ... at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/13/2017)... PUNE, India , April 13, 2017 According ... Identity Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication ... by MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 ... Annual Growth Rate (CAGR) of 17.3%. ... ...
(Date:4/11/2017)... 11, 2017 Research and Markets has announced ... report to their offering. ... global eye tracking market to grow at a CAGR of 30.37% ... Tracking Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
Breaking Biology News(10 mins):
(Date:9/17/2017)... ... 17, 2017 , ... GeneOne Life Science, Inc. announces that ... Safety (KMFDS) for an Investigational New Drug application for a Phase I/IIa study ... The study in Korea represents the second clinical trial for GLS-5300. , ...
(Date:9/14/2017)... ... September 14, 2017 , ... Boston Strategic ... experience with Health Economics and Outcomes Research (HEOR) and ‘big data’ to provide ... 2014, US healthcare spending exceeded $3.0 trillion with nearly 1/3 spent on hospitalizations. ...
(Date:9/13/2017)... ... 13, 2017 , ... AMRI, a global contract research, development ... and quality of life for more than 25 years, today announced that John ... the International Standards Organization/Technical Committee 194: Biological and Clinical Evaluation of Medical ...
(Date:9/12/2017)... (PRWEB) , ... September 12, 2017 , ... It wasn’t ... months, it has been hot, hot, hot, as Lajollacooks4u has had a record-breaking number ... , Guests came from far and wide to celebrate company outings, family get-togethers, anniversaries ...
Breaking Biology Technology:
Cached News: