HOME >> BIOLOGY >> NEWS
A test for sensitivity of normal tissue to radiation damage?

Researchers in Denmark have identified specific changes in the basic building blocks of DNA that can affect how sensitive a patient is to radiotherapy. Their findings offer a glimmer of hope that it might be possible to develop gene-based predictive tests that would enable doctors to work out the highest dose a patient could tolerate, thereby improving the efficacy of radiotherapy treatment.

Dr Nicolaj Andreassen told a news conference at ECCO12 The European Cancer Conference that he and his colleagues had studied five genes that were known to be involved in the body's response to radiation. They had looked at the sequence of the four different nucleotides (A, T, G and C) that make up the DNA of each gene and found particular places in the genetic sequence where the sequence varied from the norm in a way that could affect the proteins that the gene was responsible for coding for (or making).

The spots on the genes where these variations are found are called single nucleotide polymorphisms (SNPs), and they represent sites where a number of people have a nucleotide that is different to the nucleotide that most people would have for instance, a T instead of a C. SNPs mean that certain people may have a protein that works in a different way to the corresponding protein in other people, and these differences in protein function contribute to making us different to one another and with bodies that behave in different ways to external challenges such as radiotherapy.

Dr Andreassen, a research fellow at the Department of Experimental Clinical Oncology at Aarhus University Hospital, Denmark, found that in 41 women treated with radiotherapy after a mastectomy between 1978 and 1982, five SNPs in four genes correlated with different levels of two types of radiation damage: subcutaneous fibrosis (scarring under the skin) and telangiectasia (an increase in small blood vessels under the skin).

The XRCC1 and XRCC3 genes code for proteins invo
'"/>

Contact: Margaret Willson
m.willson@mwcommunication.org.uk
45-3252-4163
Federation of European Cancer Societies
22-Sep-2003


Page: 1 2 3 4

Related biology news :

1. Antibiotics alter GI tract microbes and increase lung sensitivity to allergens
2. Genetics, alcohol sensitivity, and behavior
3. Researchers determine a contributing genetic factor of photosensitivity in lupus patients
4. New clinical study uncovers mechanism by which chromium picolinate may enhance insulin sensitivity
5. Ovarian tumor cell sensitivity then resistance - to chemotherapy linked to genetic abnormality
6. Lower insulin sensitivity found In Mexican-Americans, regardless of behavioral and metabolic factors
7. Ten new candidate genes associated with salt sensitivity and hypertension are identified in rats
8. Climate sensitivity may be higher than many think, researchers say
9. Yale physicists first to create a squeezed state of atoms, which could lead to improved sensitivity ofnavigation systems used on planes and ships
10. Genetic variation in sensitivity to estrogen may mask endocrine disruption
11. Good news for "wusses": Research links pain sensitivity to gene

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... , April 24, 2017 ... and partner with  Identity Strategy Partners, LLP (IdSP) ... "With or without President Trump,s March 6, 2017 ... Terrorist Entry , refugee vetting can be instilled with ... resettlement. (Right now, all refugee applications are suspended ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced ... will feature emerging and evolving technology through ... Innovation Summits will run alongside the expo portion of ... sessions, panels and demonstrations focused on trending topics within ... advanced design and manufacturing event will take place June ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Firmex ... solution that makes it easy for organizations to send and gather large files ... FTP software or email file size limitations. , Using the same market-tested ...
(Date:5/23/2017)... ... May 22, 2017 , ... A new Technology Hot ... California, this August will feature high-level speakers on quantum devices, graphene electronic tattoo ... and Photonics, the largest multidisciplinary optical sciences meeting in North America, will run ...
(Date:5/23/2017)... ... ... Cambridge Semantics , the leading provider of Big Data management and ... Expo in Boston May 23-25 with a featured speaker and solution demos of ... is also a finalist for the Best of Show award. , James LaPointe, Managing ...
(Date:5/21/2017)... LOS ANGELES, CA (PRWEB) , ... May 19, ... ... at the annual meeting and educational conference of the American Association of Bioanalysts ... at the Galleria Hotel in Houston. The conference reinforces AAB’s commitment to excellence ...
Breaking Biology Technology:
Cached News: