HOME >> BIOLOGY >> NEWS
A viral cure for type 1 diabetes

Viruses can both cause and prevent autoimmune disease. In order to understand this dualism, Matthias von Herrath and colleagues from the La Jolla Institute for Allergy and Immunology in California exposed prediabetic mice to viral infections. In the January 2 issue of the Journal of Clinical Investigation the authors report that infection with lymphocytic choriomeningitis virus (LCMV) during the prediabetic period completely abolished the diabetic process in two distinct mouse models.

This protection against the development of type 1 diabetes correlated with a reduced number of autoaggressive CD8 T cells in pancreatic islets. Increased production of the chemokine CXCL-10 in pancreatic lymph nodes redirected cells of the immune response away from the b cells. Once in the pancreatic lymph node, CD8 lymphocytes underwent increased apoptosis, which was directly dependent on TNF-a and indirectly on IFN-g production. The data indicate that proinflammatory cytokines and chemokines induced by viral infection can influence ongoing autoaggressive processes beneficially at the preclinical stage if produced at the correct time, location, and level. Therefore viruses that do not directly destroy b cells may actually enhance the course of autoimmune diabetes.


'"/>

Contact: Brooke Grindlinger
science_editor@the-jci.org
212-342-9006
Journal of Clinical Investigation
2-Jan-2004


Page: 1

Related biology news :

1. First glimpse of DNA binding to viral enzyme
2. X marks the spot: Vector insertion is viral specific
3. Retroviral gene therapy? ASLV, HIV, and MLV show distinct target site preferences
4. Researchers develop better understanding of immune response to viral infection
5. New papillomavirus target could lead to specific antiviral drugs for precancerous cervical lesions
6. Sick Kids researchers look at viral triggers for multiple sclerosis in children
7. The catch 22 of immune response to AIDs viral infection
8. Purdue biologists expose the inner workings of viral machine
9. Budding viral hijackers may co-opt cell machinery for the getaway
10. Retroviral protein triggers proliferation of immune cells
11. Purdue researchers expose Docking Bay for viral attack

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/20/2018)... ... November 20, 2018 , ... Like many large breed dogs, Jack, a ... was a year old, his mom, Rebecca, noticed he was slow to get up ... veterinarian and her suspicions were confirmed: Jack had bilateral hip dysplasia, a congenital condition ...
(Date:11/15/2018)... (PRWEB) , ... November 15, 2018 , ... ... integrator of custom industrial automation and IT solutions with 140 employees on both ... Control Systems Integrators Association (CSIA) Certification. CSIA Certified control system integrators ...
(Date:11/15/2018)... ... November 14, 2018 , ... ... MD, founder and medical director of Flatiron Functional Medicine to its Medical Advisory ... Dr. Carnahan will bring to uBiome extensive experience in treating the root causes ...
Breaking Biology News(10 mins):
(Date:11/7/2018)... ... ... Diversified Technologies, Inc. (DTI) has installed a PEF (Pulsed Electric Field) ... Innovation at ASU. Funded by a USDA NIFA SBIR, the purpose of the system ... control applications. , Algae ponds get up to 50% consumed by predators and the ...
(Date:11/5/2018)... ... November 05, 2018 , ... GlycoMark, Inc., the exclusive provider ... its website, http://www.glycomark.com , as part of National Diabetes Month. The ... the website in November from 9 a.m. – 5 p.m. ET weekdays for ...
(Date:10/31/2018)... ... October 30, 2018 , ... Rooam , the premier payment platform ... this winter. After its acquisition of the Tally payment app, the leading payment platform ... tips, Rooam will grow its market share and increase the number of restaurant and ...
(Date:10/31/2018)... ST. LOUIS, Mo. (PRWEB) , ... October 30, 2018 , ... ... Consider Corn Challenge contest. The goal of this global competition is to find new ... competition. , In 2017, America’s corn farmers produced 14.6 billion bushels of corn and ...
Breaking Biology Technology:
Cached News: