HOME >> BIOLOGY >> NEWS
ADHD in a SNAP: The SNAP gene in attention deficit hyperactivity

Attention Deficit Hyperactivity Disorder (ADHD) is a neuropsychiatric condition characterized by hyperactive-impulsive behavior and persistent inattention. Individuals with this condition experience social and academic dysfunction. It is postulated that a developmental failure in the brain mechanism underlies self-control and inhibition in ADHD. ADHD affects approximately 3 to 6% of children from different geographical regions worldwide. Boys are affected more frequently than girls, with the ratio ranging from 3:1 to 9:1. Family studies have indicated a strong genetic component in susceptibility to ADHD. An approximate five to six fold increase in the frequency of ADHD among first-degree relatives when compared with the general population was observed. A number of twin studies have estimated the heritability of ADHD to range from 39% to 91% for various symptoms of the disorder.

Synaptosomal-associated protein 25 (SNAP-25) is a protein which is expressed highly and specifically in the nerve cells. The gene encodes a protein essential for synaptic vesicle fusion and neurotransmitter release. Animal model studies have shown that the coloboma mouse mutant has a hyperactive phenotype similar to that of ADHD. This model was shown to be the result of a deletion of the SNAP-25 gene. This deletion may have a direct consequence on the neurotransmitter release that has been implicated in the susceptibility to ADHD. DNA variations within or closely mapped to the SNAP-25 gene may alter the level of expression of the gene and hence may have an effect on the neurotransmitter release. We analysed 93 ADHD trios (child, mother and father) from Ireland and found increased preferential transmission of SNAP-25/DdeI variant to ADHD cases (c2= 6.55, p = 0.01). This provides preliminary evidence for the involvement of SNAP-25 in predisposing to ADHD at least in the Irish population. Replication of these results is required to firmly implicate SNAP-25 as a predisposing factor for A
'"/>

Contact: Aimee Midei
molecularpsychiatry@mednet.ucla.edu
310-206-6739
Molecular Psychiatry
23-Sep-2002


Page: 1 2

Related biology news :

1. Adult alcoholism and attention-deficit hyperactivity disorder are connected
2. Rutgers researcher advances understanding of attention deficit disorder and schizophrenia
3. Too little attention is paid to the side effects of emission-limiting measures
4. Is there a link between soy formula and attention deficit disorder?
5. The immune system may be involved in the susceptibility to childhood attention deficit hyperactivity disorder (ADHD)
6. Neuronal choir hums in unison to rivet brains attention
7. Why some people just cant seem to pay attention
8. Pay attention to potassium channels! First steps in the molecular identification of SK channels and their role in neuronal signal encoding.
9. Brain cell chorus appears as attention increases
10. Professor says college athletic departments must pay more attention to eating disorders
11. How alcohol use during pregnancy can lead to attention-deficit/hyperactivity disorder

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/5/2018)... ... October 04, 2018 , ... High dose of biotin may cause ... such as cardiac troponin has serious clinical complications. There is an increasing trend of ... still unknown. , High dose of biotin supplement use may continue to increase ...
(Date:10/3/2018)... ... October 03, 2018 , ... ... commercialization of first-in-class stromal cell immunotherapies, announced that ORBCEL-M™, a second generation ... diabetes and progressive diabetic kidney disease in a four-site, pan-European Phase I/II ...
(Date:10/2/2018)... ... October 02, 2018 , ... Through this webinar, sponsored by ... They will also learn the role of calcium kinetics in cardiac safety testing. The ... officer at PPSC Biography; and Tsang Wai Lam, an assay development scientist at PPSC. ...
Breaking Biology News(10 mins):
(Date:10/11/2018)... ... October 11, 2018 , ... ... and software solutions, in collaboration with HP, the global leader in printing, has ... GHS Chemical Labels on all HP PageWide Printers. , The award-winning Avery UltraDuty ...
(Date:10/5/2018)... ... 2018 , ... Earthres Group, Inc., a multi-disciplinary engineering firm, ... identity and better reflects its current breadth of markets and services. Marketing now ... related support services to clients in seven market sectors, and currently operates in ...
(Date:10/2/2018)... (PRWEB) , ... October 02, 2018 , ... ... or ignored, contamination endangers the reliability and reproducibility of experimental data. Each lab ... , In this educational webinar, which is sponsored by Eppendorf , attendees ...
(Date:9/28/2018)... ... September 28, 2018 , ... ... tech innovators, engineers, and scientists from around the world, is excited to announce ... of San Marcos, as the winner of the LabRoots Summer 2018 Textbook Scholarship, ...
Breaking Biology Technology:
Cached News: