Matthew R. Jones, Ph.D. Harvard School of Public Health
Dr. Jones' research centers on determining how immune cells and lung cells communicate with each other to fight off infection and protect the lungs. Interleukin-6 (IL-6) is an intercellular mediator that is essential to overcoming pneumonia infections. With APS funding, he and his colleagues will investigate how IL-6 is made and how it directs gene expression, immunity, and physiology in the lungs.
Takuya Sakaguchi, Ph.D. University of California, San Francisco
Dr. Sakaguchi's research focus is the molecular mechanism underlying liver formation (organogenesis). Though the liver is one of the major digestive organs vital to human physiology, the mechanism underlying liver organogenesis is largely unknown. He is now using a forward genetic approach in zebrafish to identify new factors that are key to liver organogenesis. This study will shed new light on liver development and will likely contribute to the future of liver regeneration technology.
The aim of the APS Postdoctoral Fellowship is to advance the study of physiological genomics by furthering understanding of the human genome in the context of the whole body. The Fellowship was established to provide training that enables outstanding young scientists to combine the tools of cellular and molecular biology in the setting of the whole animal. Through these fellowships, awarded annually since 1995, APS has contributed more than $1 million to physiological genomics research.