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AVAX Technologies' AC Vaccine™ improves relapse-free survival

-- Preclinical Data Presented at the 91st Annual Meeting of the American Association of Cancer Research --

Kansas City, MO, April 5, 2000 -- AVAX Technologies, Inc. (NASDAQ: AVXT) today announced the presentation of preclinical data on its AC Vaccine™ technology, an autologous cell cancer vaccine, at the 91st Annual Meeting of the American Association for Cancer Research (AACR). The presentation outlined findings in a mouse model of breast cancer, indicating that vaccination with AVAX's AC Vaccine technology resulted in improved relapse-free survival. The dosage regimen used in the animal experiments is very similar to that currently being used in the company's pivotal registration trial of M-Vax™ for metastatic melanoma and in Phase 2 studies of O-Vax™ for ovarian cancer. This study was supported by a grant from AVAX and was conducted at the University of Illinois, Chicago, by Dr. Margalit B. Mokyr.

The study, entitled "Vaccination with DNP-Modified 410.4 Mammary Tumor Cells Leads to the Eradication of Established Metastases via a CD8+ T-Cell-Dependent Mechanism," was designed to assess the therapeutic potential of vaccination with irradiated tumor cells modified with the hapten "DNP" (AVAX's AC Vaccine technology), compared to treatment with tumor cells that were not modified via the AVAX process. The studies utilized a specific murine (mouse) mammary carcinoma, which closely models human breast cancer in terms of its immunogenicity, metastatic properties and growth characteristics. The data illustrated that treatment with DNP-modified irradiated tumor cells improved relapse-free survival of the mice, while treatment with unmodified cells had no effect. The study further indicated that vaccination with modified tumor cells elicited an immune response, which was identified by activation of CD8+ T-cells, and showed that these cells are a necessary component for the vaccine to achieve its effect in this model.
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Contact: Olga Fleming
ofleming@cpronline.com
201-641-2408 ext. 51
AVAX Technologies, Inc.
4-Apr-2000


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