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AVAX Technologies' M-Vax™ cancer vaccine extends five-year overall survival in patients with lymph node metastatic melanoma

Data Gathered from a Larger Patient Population with Ten-Year Follow-Up Consistent with Previously Reported Data
New Findings Suggest Improved Survival Even After Patient Relapse
Data Presented at the Annual Meeting of the American Society of Clinical Oncology

AVAX Technologies, Inc. (NASDAQ: AVXT) today announced the presentation of data at the 36th Annual Meeting of the American Society of Clinical Oncology (ASCO)(May 20-23) in New Orleans on the company's autologous cell vaccine (AC Vaccine™) M-Vax™ for the treatment of metastatic melanoma. The data from additional studies confirm and expand the results of a study published in 1997 showing that M-Vax increases the survival rate of patients with advanced Stage III melanoma, even after disease recurrence.

The trials, which began in 1989, include 214 patients. All had melanoma with large (at least 3 cm diameter) regional lymph node metastases. Following removal of the lymph node masses, patients were treated with M-Vax by one of four dosage-schedules. The median follow-up time for these patients is 4.4 years, and the longest is over 10 years. Fifty-four patients have been observed for five years or more. M-Vax caused no major side effects.

The overall five-year survival rate from all these trials for patients with spread of melanoma to one nodal area was 50%, versus historical five-year survival rates of approximately 20-25% for patients treated with surgery alone. Of note, this group included high-risk patients with clinical features usually associated with poor prognosis, such as in-transit metastases, tumor masses that spread to the skin between the primary site and the lymph node. Another high-risk group treated in this study included patients with spread of melanoma to two nodal areas. In this group, the five-year survival was 35%, versus a 10% five-year survival rate when patients are treated with lymph node surgery alone.

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Contact: Sue Yeoh
syeoh@cpronline.com
201-641-2408 ext. 43
AVAX Technologies, Inc.
22-May-2000


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