HOME >> BIOLOGY >> NEWS
Access to DNA secrets yields better understanding of genes, possible tool for disease diagnosis

DALLAS July 8, 2004 A new technique for examining DNA is giving scientists a more detailed picture of which genes have the propensity for activation, offering a new tool for understanding how genes function and possibly for diagnosing disease.

The technology, called a chromatin array, was developed by researchers at UT Southwestern Medical Center at Dallas and is described in the July issue of the journal Genome Research.

DNA, which contains the genetic instructions needed to make a human or any other life form, is a long molecule that is tightly compacted in a cell's nucleus. Various pieces of DNA are constantly being compressed and expanded like the folds of an accordion as a cell responds to its changing needs.

When the DNA relaxes, or expands, proteins called transcription factors gain access to the genetic code to "read" its instructions for making a molecule called RNA, which in turn makes other proteins that carry out life's essential functions, from immune response and muscle contraction to cholesterol and hormone regulation.

When DNA is highly compacted, like a closed accordion, it's not as accessible to transcription proteins, and cannot make RNA, said Dr. Harold "Skip" Garner, professor of biochemistry and internal medicine at UT Southwestern and senior author of the study.

Using the chromatin array, UT Southwestern researchers can detect the relative compactness of several stretches of DNA at a time with very high resolution, allowing them to determine which genes have the propensity for making RNA. They found that for many genes, but not all, the more open the DNA is, the more RNA is produced.

"The interesting genes are the ones that don't behave this way," Dr. Garner said.

Exactly what controls compaction and expansion of DNA is still under scientific debate. In their next set of experiments, Dr. Garner and his team will apply various drugs such as those used in cancer therapy to cells in
'"/>

Contact: Amanda Siegfried
Amanda.siegfried@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
8-Jul-2004


Page: 1 2 3

Related biology news :

1. BioMed Central to consult funders and librarians over Open Access payment model
2. Open Access journals proven to compete on quality
3. OUP launch a new Open Access Journal on Complementary and Alternative Medicine
4. BioMed Central explodes Open Access myths
5. Open Access Initiative from Oxford Journals
6. Access to healthy foods limited in poor neighborhoods
7. Sick Kids Improves Access To Global Genome Database
8. Anthrax enzyme images reveal secrets of antibiotic resistance, suggest new drug design
9. Genes expose secrets of sex on the side
10. Entrepreneurs to be told how natures secrets can improve business
11. Stuck on you: Scientists lay bare secrets of bacterial attachment proteins

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2019)... , ... June 14, 2019 , ... ... invited to lecture at the fifth annual Neodent World Congress. Attended by thousands ... innovative progress and latest advancements in the world of dentistry. The three-day event ...
(Date:6/11/2019)... , ... June 12, 2019 , ... ... antibody discovery services, Abveris plans to leverage the Geneious Biologics platform as a ... Souders, Chief Technology Officer at Abveris, says: “The Geneious team has done an ...
(Date:6/4/2019)... ... June 04, 2019 , ... In’Tech Medical SAS ( ... Q1-19 revenues of $31M, up 12% from Q1-18. The growth is associated with ... & operational excellence initiatives worldwide. , Laurent Pruvost , President & CEO ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... ... June 11, 2019 , ... ... Stem Cells Inc. (PSC) , has announced that their GMP facility for cell ... Drug Branch for manufacturing. This is an important milestone for VetStem as ...
(Date:5/31/2019)... ... May 29, 2019 , ... ... applications from the USPTO providing proprietary interest to our methodology, processes, and ... DISORDER DIAGNOSIS AND TREATMENT… extends Somnology’s IP rights including our proprietary sleep ...
(Date:5/22/2019)... ... May 22, 2019 , ... Artemis (formerly Agrilyst), the ... Series A funding round co-led by Astanor Ventures and Talis Capital ... and iSelect Fund . The company has raised $11.75m to date and ...
(Date:5/14/2019)... ... May 13, 2019 , ... Leak Detection Associates ... the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries’ is excited to announce ... to improve LDA’s ability to communicate directly with the marketplace; serving as a ...
Breaking Biology Technology:
Cached News: