Activity of calcium-handling gene appears to prevent cardiac arrhythmias

Activation of a gene already shown to correct heart failure by improving calcium metabolism in the heart muscle may also help prevent arrhythmias, sometimes-dangerous disturbances in heart rhythm, according to a study from the Massachusetts General Hospital (MGH) Cardiovascular Research Center (CVRC). The article, being released today in the early online edition of Proceedings of the National Academy of Sciences, describes how overexpression of the protein SERCA2a in the hearts of rats reduced the incidence of arrhythmia after heart muscle injury.

"If these results hold up in future studies, SERCA2a gene therapy could help protect patients at risk of arrhythmia because of existing heart disease or prevent rhythm disturbances that can occur after percutaneous coronary interventions," says Roger J. Hajjar, MD, of the CVRC and the MGH Heart Failure Center, the paper's senior author.

While arrhythmias are common, certain types may indicate serious heart disease. Significant rhythm disturbances of the ventricles the lower chambers that pump blood out of the heart can be dangerous. Ventricular fibrillation, in which the muscles contract in a rapid, uncoordinated fashion, is the leading cause of cardiac death occurring outside of a hospital. Such arrhythmias need to be stopped by application of electrical current through a defibrillator, and some patients with a history of fibrillation have permanent defibrillators implanted to correct their heart rhythm.

Contraction of any muscle cell requires the correct movement of calcium within the cell. It has been known for 20 years that heart failure in which the heart muscle is weak and does not pump effectively is associated with abnormal handling of calcium. Earlier research has shown that SERCA2a, which helps transport calcium between cellular structures, does not function well in heart failure. Cellular and animal studies by the same MGH CVRC team led by Federica del Monte, MD, PhD have con

Contact: Michelle Marcella
Massachusetts General Hospital

Page: 1 2 3

Related biology news :

1. Activity detailed for sirtuins, involved in metabolism, aging, gene expression
2. Activity decrease in exercising older adults linked to decline in resting metabolism
3. UT Southwestern Researchers Find Way To Control Gene Activity, Opening Way For Cancer Drugs
4. Research Findings Suggest Potent, Broad-Spectrum Antiviral Activity For Vertexs Investigational IMPDH Inhibitor VX-497
5. Research Shows Wrong Activity Worse Than No Activity In Developing Brain
6. Chopping And Cooking Affect Garlics Anti-Cancer Activity
7. Ribozyme Pharmaceuticals, Inc. Demonstrates Potent Activity Of A Ribozyme Targeted Against The Hepatitis C Virus
8. Phase III Results Suggest Potent Antiviral Activity For Vertex And Glaxo Wellcomes Second-Generation HIV Protease Inhibitor Agenerase TM
9. HIV Infected Adults In UCSF Study Show Evidence Of Thymus Activity
10. Researchers Discover Novel Gene Family Responsible For Pacemaker Activity In Brain And Heart
11. New Test Opens Window On Corrosive Free-Radical Activity In Individuals

Post Your Comments:

(Date:8/14/2019)... (PRWEB) , ... August 14, 2019 , ... ... broadcast 4Q/2019, will explore how developments in microbiome therapeutics are helping to promote ... listings for more information. , Advancements will educate about the DECODE.DESIGN.CURE™ technology platform, ...
(Date:8/14/2019)... ... , ... Representatives with MyBioGate announced that China Focus@Biotech Week will be held ... innovative projects connect with Chinese pharma and investors in healthcare innovation,” said Miao Guo, ... that as a part of Biotech Week Boston – the annual biotech festival at ...
(Date:8/14/2019)... ... ... Reck of Veterinary Medical Center of Fort Mill has recently begun providing ... own geriatric Australian Shepherd, Simon, was treated in June 2019 for osteoarthritis in his shoulders, ... was weak, and he struggled to play fetch and other games with his family. ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... 13, 2019 , ... INDIGO Biosciences, Inc. (INDIGO), the recognized ... appointment of Mark McLoughlin to the Company’s Board of Directors. Mark brings four ... his healthcare expertise and extensive background in laboratory and scientific products manufacturing, distribution, ...
(Date:8/8/2019)... ... August 08, 2019 , ... ... sales and service organizations, today announced that the company’s Studio Intelligent Virtual Agent ... IVA market . Inference will officially accept the award at Frost & Sullivan’s ...
(Date:8/6/2019)... (PRWEB) , ... August 06, 2019 , ... ... Radio (LSMR) have joined forces in launching the biweekly SDBN BUZZ podcast focused ... growth. SDBN BUZZ podcast will also serve to promote the region and attract ...
(Date:8/6/2019)... , ... August 05, 2019 , ... ... Casarella has been recognized as a distinguished leader by PharmaVOICE magazine, earning him ... an article in the magazine’s July/August special issue. , As the executive vice ...
Breaking Biology Technology:
Cached News: