HOME >> BIOLOGY >> NEWS
Adaptive changes in the genome may provide insight into the genetics of complex disease

One of the most comprehensive studies of the forces that have shaped patterns of human genetic variation has found strong evidence for the action of natural selection, which may help explain why certain people are at risk for a variety of conditions and others are not.

The findings were published online this week for the journal Public Library of Science Biology in a paper titled "Population History and Natural Selection Shape Patterns of Genetic Variation in 132 Genes." For the paper, researchers studied the molecular evolution of 132 genes by comprehensively resequencing them in 24 African-Americans and 23 European-Americans. The results showed strong evidence for natural selection at eight genes in the European-American population, likely explained by the different environmental conditions people encountered as they moved into Europe sometime between 25,000 to 50,000 years ago.

"Our results suggest that the migration of humans out of Africa into new environments was accompanied by genetic adaptations to emergent selective forces," said Dr. Joshua Akey, lead author of the paper and an assistant professor in the Department of Genome Sciences at the University of Washington in Seattle.

If you were to compare the genomes of two randomly selected individuals you would find that they are not identical, but on average contain differences every 1,000 base pairs or so. The most common form of these differences is "single nucleotide polymorphisms," or SNPs (pronounced 'snips').

Occasionally, new SNPs arise that allow certain individuals in a population to be healthier and produce more offspring, and these variants become more frequent through the process of natural selection. Although there is considerable interest in finding regions of the human genome that have been targets of natural selection, the tools and resources needed to do so are only now becoming widely available.

In the paper, r
'"/>

Contact: Walter Neary
wneary@u.washington.edu
206-685-1323
University of Washington
8-Sep-2004


Page: 1 2 3

Related biology news :

1. Adaptive mutation is common in E. coli, say IU researchers
2. UC Riverside to play active role in Institute for Complex Adaptive Matter
3. Gene changes linked to increased eye pressure may have implications for glaucoma therapy
4. Study finds plant enzyme function changes with location in cell
5. Protein controls acid in cells by direct detection of volume changes, study finds
6. Gene mutation causes progressive changes to cell structure in children with Progeria
7. Researchers develop blood test that can detect genetic changes in progressive breast cancer
8. Unexpected changes in Earths climate observed on the dark side of the moon
9. Small gene changes in some leukemia patients may explain varying responses to chemotherapy
10. Childrens eating patterns show striking changes in two decades
11. New method is first to mimic subtle genetic changes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/14/2019)... ... August 14, 2019 , ... ... explore how developments in microbiome therapeutics are helping to promote normal immune function ... information. , Advancements will educate about the DECODE.DESIGN.CURE™ technology platform, which rapidly develops ...
(Date:8/14/2019)... TORONTO (PRWEB) , ... August 13, 2019 , ... ... Cancer Medicine Team, Division of Molecular Pathology, Institute of Cancer Research (ICR) in ... (5pm BST/UK) to learn about the process of biomarker and companion diagnostic development ...
(Date:8/6/2019)... ... August 05, 2019 , ... Keck Graduate Institute (KGI) President ... Pharmacy and Health Sciences (SPHS). , “Dean Zdanowicz is highly regarded as an innovative ... Jim Widergren. “He is a great choice to build on the success of the ...
Breaking Biology News(10 mins):
(Date:6/11/2019)... , ... June 10, 2019 , ... ... and technology in an upcoming episode, scheduled to broadcast 4Q/2019. Check your local ... Group) and will educate viewers about how its technology facilitates laboratories to improve ...
(Date:6/11/2019)... Md. and ROANOKE, Va. (PRWEB) , ... June ... ... care optimized for microlearning engagement, and Carilion Clinic, a national leader in opioid ... the latest in virtual care. , Mytonomy recently deployed its virtual ...
(Date:6/11/2019)... N.C. (PRWEB) , ... June 11, 2019 , ... ... extracellular vesicles derived from human mesenchymal stem cells (MSC-EV) are able to incorporate ... cloning ability. In a test on mice, MSC-EVs also increased the cells’ ability ...
(Date:5/31/2019)... ... , ... For many years, the primary forms of cancer treatment have been ... in immuno-oncology have led to the advent of Chimeric Antigen Receptor T (CAR T) ... known as “CARs”. The CAR enables the final product to produce chemicals in the ...
Breaking Biology Technology:
Cached News: