HOME >> BIOLOGY >> NEWS
Adding vitamin C to certain drugs may help treat Alzheimers, other brain disorders

Drugs used to treat Alzheimers and other brain disorders appear to enter the brain more easily when a vitamin C molecule is attached, according to researchers in Italy. The discovery could lead to safer and more effective drugs that target the brain, they say.

The study is tentatively scheduled to appear in the Jan. 31 print issue of the Journal of Medicinal Chemistry, a peer-reviewed publication of the American Chemical Society, the worlds largest scientific society. It was published in the Web edition of the journal on Dec. 21.

Weve opened a door for a promising new way to improve delivery of drugs into the brain using a natural nutrient, ascorbic acid [vitamin C], says Stefano Manfredini, lead investigator in the study and a professor of pharmaceutical chemistry at the University of Ferrara in Ferrara, Italy.

Some drugs that have difficulty entering the brain could cross more easily when attached to a vitamin C molecule, while some that cannot enter the brain could enter for the first time, he says. Potential applications include drugs for central nervous system diseases, viral infections (including AIDS), brain lesions, and neurodegenerative diseases including Alzheimers, Parkinsons and epilepsy, Manfredini says.

He calls the results exciting, but cautions that the data are very preliminary. So far, animal tests of at least one of the vitamin C modified drugs appear promising, but no human tests have been conducted. The new design approach will not enhance the effectiveness of all drugs, while those that do work could take several years to reach the consumer market, the researcher predicts.

One of the major problems in the treatment of brain diseases is the difficulty of distributing drugs to the central nervous system. This is due to a natural barrier, the blood brain barrier, which selectively regulates the movement of chemicals across the brain.

Researchers have known for some time that adding new compon
'"/>

Contact: Beverly Hassell
b_hassell@acs.org
202-872-4065
American Chemical Society
9-Jan-2002


Page: 1 2 3

Related biology news :

1. Adding bacteria to wounds
2. Adding acetone to compost remediates chunk TNT contaminated soil
3. Lycopene slows human prostate tumour growth in mice and combined with vitamin E is even better
4. Chemical derived from vitamin-E shows early promise as cancer drug
5. Folic acid vitamin use by women reaches all-time high, March of Dimes survey finds
6. Alterations in vitamin D receptor gene increase prostate, breast cancer risk
7. Could vitamins raise levels of bad cholesterol? Animal study suggests they might
8. New antioxidants are 100 times more effective than vitamin E
9. Study finds huge variability in vitamin E absorption
10. People with undetermined muscle/bone pain tend to be severely vitamin D deficient
11. Daily vitamins could prevent vision loss among thousands

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2016)... The global Biometric ... USD 1.83 billion by 2024, according to a ... proliferation and increasing demand in commercial buildings, consumer ... the market growth.      (Logo: ... of advanced multimodal techniques for biometric authentication and ...
(Date:6/9/2016)... innovation leader in attendance control systems is proud to announce the introduction of fingerprint ... sure the right employees are actually signing in, and to even control the opening ... ... ... Photo ...
(Date:6/7/2016)... 2016  Syngrafii Inc. and San Antonio Credit ... includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution ... will result in greater convenience for SACU members ... maintaining existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Md. , June 23, 2016 A person ... from the crime scene to track the criminal down. ... the U.S. Food and Drug Administration (FDA) uses DNA evidence ... Sound far-fetched? It,s not. The FDA ... sequencing to support investigations of foodborne illnesses. Put as simply ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge (BDC), ... new ways to harness living systems and biotechnology, announced ... (MoMA) in New York City . ... participating students, showcased projects at MoMA,s Celeste Bartos Theater ... Antonelli , MoMA,s senior curator of architecture and design, ...
(Date:6/23/2016)... NC (PRWEB) , ... June 23, 2016 , ... In ... University Hospital in Denmark detail how a patient who developed lymphedema after being treated ... tissue. The results could change the paradigm for dealing with this debilitating, frequent side ...
(Date:6/23/2016)... 2016 On Wednesday, June 22, 2016, ... 0.22%; the Dow Jones Industrial Average edged 0.27% lower to ... down 0.17%. Stock-Callers.com has initiated coverage on the following equities: ... (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing their ...
Breaking Biology Technology:
Cached News: