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Adding vitamin C to certain drugs may help treat Alzheimers, other brain disorders

rrier in its normal form. Using a group of mice that had been chemically induced to have convulsions, the researchers injected the normal molecule into the mice. This had no effect on their convulsions. When a vitamin C modified version of the drug was injected, convulsions were delayed, demonstrating the improved performance of the drug, the researchers say.

Side effects in the mice were very limited and no deaths were reported, they say.

Additional animal studies of vitamin C modified drugs are anticipated, Manfredini and his associates say. They have filed a patent for their discovery.

The researchers also believe that the in vitro cell model of vitamin C transporters used in this study will serve as a valuable tool to study one of the many mechanisms by which ascorbic acid works in the body, a mystery scientists have yet to fully understand. An understanding of these mechanisms could provide insights into many of the controversial health claims regarding vitamin C, they say.


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Contact: Beverly Hassell
b_hassell@acs.org
202-872-4065
American Chemical Society
9-Jan-2002


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