HOME >> BIOLOGY >> NEWS
Adult stem cells selectively delivered into the eye and used to control angiogenesis at TSRI

A team of researchers from The Scripps Research Institute (TSRI) has discovered a way to use adult bone marrow stem cells to form new blood vessels in the eye or to deliver chemicals that will prevent the abnormal formation of new vessels.

This technique, which involves injecting the stem cells into the eye, could potentially be used to stimulate vessel growth and address inherited degenerations of the retina in the first instance, and in the second, to treat ocular diseases resulting from abnormal retinal angiogenesis, the aberrant growth of new blood vessels in the eye, which is the leading cause of vision loss in the United States.

"This is very exciting," says Martin Friedlander, M.D., Ph.D., who led the study. "We have shown that the cells can incorporate into the [degenerating] vasculature and make it normal."

"And when loaded with antiangiogenics, they can selectively wipe out the formation of new blood vessels."

Friedlander, who is Associate Professor in the Department of Cell Biology and Chief of the Retina Service in the Division of Ophthalmology, Department of Surgery at Scripps Clinic, has had a longstanding research program looking at ways of treating eye diseases that result from abnormal angiogenesis.

Abnormal angiogenesis is the cause of visual loss in age-related macular degeneration, where new blood vessels grow under the retina, and diabetic retinopathy, where abnormal vessels grow on top of the retina. The end result is much the same in these diseases--the normal structures for the transmission of light to the back of the eye are lost, and vision is catastrophically impeded in many of the tens of millions of Americans who suffer from them.

From stem cells to vessels

Adult bone marrow stem cells are "pluripotent" which means they have the potential to develop into a number of different cell types, such as red blood cells, platelets, or lymphocytes. The group's basic technique s
'"/>

Contact: Robin B. Clark
rclark@scripps.edu
858-784-8134
Scripps Research Institute
29-Jul-2002


Page: 1 2 3

Related biology news :

1. Adult alcoholism and attention-deficit hyperactivity disorder are connected
2. Adult mouse bone marrow stem cells can become cells of the nervous system
3. Straight talk: Adult and embryonic stem cells and the future of research
4. Study: Adults maintain significant improvement in ADHD with long-term use of amphetamine
5. Adult stem cells shown to develop into all brain cell types
6. U of Minnesota study: Adult bone marrow stem cells can become liver cells
7. Adult human breast stem cell candidate found
8. Adult bone marrow stem cells can become blood vessels
9. Adult stem cell therapy for heart failure proves promising
10. Adult stem cells can produce a wealth of cell types, Science authors report
11. Study Indicates Adolescent Smokers Are More Susceptible To Long-Term DNA Damage From Smoking Than Adults Smokers

Post Your Comments:
(Date:4/15/2014)... The Royal Netherlands Academy of Arts and Sciences (KNAW) ... who have been awarded prestigious Heineken Prizes (one million ... the Heineken Prizes for their great merits to science. ... first Heineken Prize, awarded to the Austrian-American chemist Erwin ... this year,s Heineken Prizes to the following laureates: ...
(Date:4/15/2014)... that the genetic code is far more complex ... building blocks adenine, cytosine, guanine, and thymine, numerous ... assume that the newly discovered nucleic acid modifications ... extends and complements the genetic code. "The new ... standard alphabet," explained Professor Mark Helm of the ...
(Date:4/15/2014)... April 15, 2014 New research, partially funded by ... Federation, shows that consumers can improve their diets simply ... their daily meals. , In a ... and Nutrition Sciences , lead author Theresa Nicklas, DrPH, ... and Nutrition Examination Survey datasets from 2005-2010 and evaluated ...
Breaking Biology News(10 mins):Five scientists awarded prestigious Heineken Prizes 2German Research Foundation approves new priority program in the life sciences 2Eating rice boosts diet quality, reduces body weight and improves markers for health 2Eating rice boosts diet quality, reduces body weight and improves markers for health 3
(Date:1/15/2014)... January 15, 2014 This webinar ... on nonclinical and clinical safety assessment in biosimilars. ... guide a path for biosimilar drug development, however ... of biosimilarity with regards to quality, safety and ... of biosimilar drug development and registration, development strategies ...
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 ... an enhancement to its Online Web Portal for Life ... now have the ability to specify the subject matter ... nearly 50 life science sub-domains. This will help reduce ... and scientific fields, and decrease the likelihood of error. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 ... – 11 p.m. , Location: Warrington Country Club, 1360 ... Hepatitis B Foundation, the only national nonprofit organization solely ... improving the quality of life for those affected worldwide, ... 11 at Warrington Country Club in Warrington, Pa. ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
Cached News: