HOME >> BIOLOGY >> NEWS
Adult stem cells selectively delivered into the eye and used to control angiogenesis at TSRI

A team of researchers from The Scripps Research Institute (TSRI) has discovered a way to use adult bone marrow stem cells to form new blood vessels in the eye or to deliver chemicals that will prevent the abnormal formation of new vessels.

This technique, which involves injecting the stem cells into the eye, could potentially be used to stimulate vessel growth and address inherited degenerations of the retina in the first instance, and in the second, to treat ocular diseases resulting from abnormal retinal angiogenesis, the aberrant growth of new blood vessels in the eye, which is the leading cause of vision loss in the United States.

"This is very exciting," says Martin Friedlander, M.D., Ph.D., who led the study. "We have shown that the cells can incorporate into the [degenerating] vasculature and make it normal."

"And when loaded with antiangiogenics, they can selectively wipe out the formation of new blood vessels."

Friedlander, who is Associate Professor in the Department of Cell Biology and Chief of the Retina Service in the Division of Ophthalmology, Department of Surgery at Scripps Clinic, has had a longstanding research program looking at ways of treating eye diseases that result from abnormal angiogenesis.

Abnormal angiogenesis is the cause of visual loss in age-related macular degeneration, where new blood vessels grow under the retina, and diabetic retinopathy, where abnormal vessels grow on top of the retina. The end result is much the same in these diseases--the normal structures for the transmission of light to the back of the eye are lost, and vision is catastrophically impeded in many of the tens of millions of Americans who suffer from them.

From stem cells to vessels

Adult bone marrow stem cells are "pluripotent" which means they have the potential to develop into a number of different cell types, such as red blood cells, platelets, or lymphocytes. The group's basic technique s
'"/>

Contact: Robin B. Clark
rclark@scripps.edu
858-784-8134
Scripps Research Institute
29-Jul-2002


Page: 1 2 3

Related biology news :

1. Adult alcoholism and attention-deficit hyperactivity disorder are connected
2. Adult mouse bone marrow stem cells can become cells of the nervous system
3. Straight talk: Adult and embryonic stem cells and the future of research
4. Study: Adults maintain significant improvement in ADHD with long-term use of amphetamine
5. Adult stem cells shown to develop into all brain cell types
6. U of Minnesota study: Adult bone marrow stem cells can become liver cells
7. Adult human breast stem cell candidate found
8. Adult bone marrow stem cells can become blood vessels
9. Adult stem cell therapy for heart failure proves promising
10. Adult stem cells can produce a wealth of cell types, Science authors report
11. Study Indicates Adolescent Smokers Are More Susceptible To Long-Term DNA Damage From Smoking Than Adults Smokers

Post Your Comments:
(Date:11/21/2014)... 20, 2014   Atmel® Corporation (NASDAQ: ... and touch technology solutions, today launched the industry,s first ... the widest V cc range from 1.7V to ... faster I 2 C bus communication speeds, and are ... making them ideal for consumer, industrial, computer, and medical ...
(Date:11/15/2014)... NEW YORK , Nov. 13, 2014  While we ... of technology Doctor McCoy used in "Star Trek" to gain ... and tools designed to work with smartphones and tablets for ... corners of the healthcare world. This may seem a tad ... are ready to adopt some of these technological opportunities into ...
(Date:11/7/2014)... conjunction with the Glendale and ... the Verdugos has announced the " GLENDALE - ... to keep the Verdugo Regional Crime Lab operational after its ... existence, the Lab has processed more than 400 DNA samples, ... "Because our number one priority is the wellbeing of ...
Breaking Biology News(10 mins):Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2
(Date:11/22/2014)... CannLabs, Inc. (OTCQB: CANL), the ... testing methodologies relating to cannabis, today announced that it ... credit from an existing stockholder of the Company. ... commitment from one of our existing stockholders,” stated ... will help accelerate our planned expansions into the Connecticut ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 Respiratory ... simulate the proper management of life-like respiratory ailments ... lung devices . Grand Rapids-based, Michigan Instruments Inc. ... donate two of the respiratory simulation units to ... each. Grand Valley and Muskegon Community College are ...
(Date:11/21/2014)...   TRU-D SmartUVC LLC and its UK partners, ... disinfection robot, TRU-D SmartUVC, at FIS 2014 in ... 26 at Stand 23. The conference, hosted by ... largest infection-related event of its kind and brings ... the leading events of its type throughout the world. This ...
(Date:11/21/2014)... Alto, Calif. (PRWEB) November 20, 2014 ... a nonprofit, public policy research organization representing leading ... pharmaceutical firms, and PwC US today ... states in life sciences industry growth. The trend ... 2013. The 2015 California Biomedical Industry Report ...
Breaking Biology Technology:CannLabs Secures $750,000 Line Of Credit 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4
Cached News: