Alcohol Consumption, Resistance To Its Effects Related To Levels Of Neurotransmitter, Say UW Researchers

Science is still a long way from understanding why some people are more prone to alcoholism and alcohol abuse than others, but University of Washington researchers have discovered that concentrations of a neurotransmitter in the brains of mice are directly related to alcohol consumption and resistance to the sedative effects of alcohol.

Writing in tomorrow's issue of the journal Nature, the UW scientists report that genetically altered mice that do not produce the naturally occurring brain chemical or neurotransmitter called neuropeptide Y (NPY) drank significantly more alcohol and were less affected by its sedative, or sleep-inducing, effects than normal mice. In addition, genetically engineered mice that produce abnormally high levels of NPY drank less alcohol than normal mice and were highly prone to succumb to its sedative effects.

"This is the first direct demonstration that there are altered levels of alcohol consumption if you change the amount of NPY present in the brains of rodents," said Todd Thiele, who headed the UW team along with Richard Palmiter. "Alcohol consumption and resistance are inversely proportional to concentrations of NPY in the brain. Together, these data indicate that in rodents there is a relationship between NPY levels and the willingness to voluntarily consume alcohol."

The researchers cautioned that while their results with mice are convincing, further research is necessary to determine if there is a relationship between NPY and alcohol consumption and abuse in humans. They next plan to try to find the mechanism by which NPY in the brain modulates alcohol drinking.

"This study is important for two reasons," according to Dr. Enoch Gordis, director of the National Institute on Alcohol Abuse and Alcoholism. "It indicates that peptides related to appetite and anxiety are significant areas for study in alcohol research and that drugs designed to interact with components of the n

Contact: Joel Schwarz
University of Washington

Page: 1 2

Related biology news :

1. Alcohol-use and depression among pregnant and postpartum women
2. Alcoholism risk linked to gene involved in brain chemistry
3. Alcohol consumption can damage hearing
4. Alcohol-dependence gene identified
5. Alcohol exposure in pre- and early post-natal stages may cause insulin resistance
6. Alcoholics with antisocial personality disorder have blunted emotional reactivity
7. Alcohols pharmacological properties, not smell or taste, reinforce its effects
8. Alcohol abuse may increase susceptibility to HIV infection
9. Alcohol researchers relate a genetic factor to anxiety in women
10. Alcohol researchers identify a genetic basis of pain response
11. Alcohols effects on testosterone

Post Your Comments:

(Date:11/20/2015)... OXFORD, Connecticut , November 20, 2015 ... biometric authentication company focused on the growing mobile commerce ... its CEO, Gino Pereira , was recently interviewed ... The interview will air on this weekend on ... Bloomberg Latin America . --> NXTD ) ...
(Date:11/19/2015)... 2015  Based on its in-depth analysis of the ... with the 2015 Global Frost & Sullivan Award for ... presents this award to the company that has developed ... of the market it serves. The award recognizes the ... on customer base demands, the overall impact it has ...
(Date:11/19/2015)... 19, 2015  Although some 350 companies are actively ... a few companies, according to Kalorama Information. These include Roche ... the market share of the 6.1 billion-dollar molecular testing ... Market for Molecular Diagnostic s .    ... still controlled by one company and only a handful ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... and HOLLISTON, Mass. , Nov. 25, ... HART ), a biotechnology company developing bioengineered organ ... Jim McGorry will present at the LD Micro ... at 2:30 p.m. PT. The presentation will be webcast ... days. Management will also be available at the conference ...
(Date:11/25/2015)... 25, 2015  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ... and CEO of Neurocrine Biosciences, will be presenting at ... New York . http://www.neurocrine.com .   ... approximately 5 minutes prior to the presentation to download ... presentation will be available on the website approximately one ...
(Date:11/25/2015)... , Nov. 25, 2015 /PRNewswire/ - Aeterna Zentaris Inc. ... its business and prospects remain fundamentally strong and ... (zoptarelin doxorubicin) recently received DSMB recommendation to continue ... following review of the final interim efficacy and ... Primary Endpoint in men with heavily pretreated castration- ...
(Date:11/25/2015)... ... November 25, 2015 , ... A long-standing partnership ... Professionals (OPBAP) has been formalized with the signing of a Memorandum of Understanding. ... OPBAP leaders Capt. Karl Minter and Capt. Albert Glenn Tuesday, November 24, 2015, ...
Breaking Biology Technology:
Cached News: