HOME >> BIOLOGY >> NEWS
Alcohol Consumption, Resistance To Its Effects Related To Levels Of Neurotransmitter, Say UW Researchers

Science is still a long way from understanding why some people are more prone to alcoholism and alcohol abuse than others, but University of Washington researchers have discovered that concentrations of a neurotransmitter in the brains of mice are directly related to alcohol consumption and resistance to the sedative effects of alcohol.

Writing in tomorrow's issue of the journal Nature, the UW scientists report that genetically altered mice that do not produce the naturally occurring brain chemical or neurotransmitter called neuropeptide Y (NPY) drank significantly more alcohol and were less affected by its sedative, or sleep-inducing, effects than normal mice. In addition, genetically engineered mice that produce abnormally high levels of NPY drank less alcohol than normal mice and were highly prone to succumb to its sedative effects.

"This is the first direct demonstration that there are altered levels of alcohol consumption if you change the amount of NPY present in the brains of rodents," said Todd Thiele, who headed the UW team along with Richard Palmiter. "Alcohol consumption and resistance are inversely proportional to concentrations of NPY in the brain. Together, these data indicate that in rodents there is a relationship between NPY levels and the willingness to voluntarily consume alcohol."

The researchers cautioned that while their results with mice are convincing, further research is necessary to determine if there is a relationship between NPY and alcohol consumption and abuse in humans. They next plan to try to find the mechanism by which NPY in the brain modulates alcohol drinking.

"This study is important for two reasons," according to Dr. Enoch Gordis, director of the National Institute on Alcohol Abuse and Alcoholism. "It indicates that peptides related to appetite and anxiety are significant areas for study in alcohol research and that drugs designed to interact with components of the n
'"/>

Contact: Joel Schwarz
joels@u.washington.edu
206-543-2580
University of Washington
26-Nov-1998


Page: 1 2

Related biology news :

1. Alcohol-use and depression among pregnant and postpartum women
2. Alcoholism risk linked to gene involved in brain chemistry
3. Alcohol consumption can damage hearing
4. Alcohol-dependence gene identified
5. Alcohol exposure in pre- and early post-natal stages may cause insulin resistance
6. Alcoholics with antisocial personality disorder have blunted emotional reactivity
7. Alcohols pharmacological properties, not smell or taste, reinforce its effects
8. Alcohol abuse may increase susceptibility to HIV infection
9. Alcohol researchers relate a genetic factor to anxiety in women
10. Alcohol researchers identify a genetic basis of pain response
11. Alcohols effects on testosterone

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/22/2016)... 2016  As part of its longstanding mission to improve ... company, recently released its latest children,s book, titled ... on the topics of inheritance and variation of traits that ... in elementary school classrooms in the US. ... Ariana Killoran , whose previous book with 23andMe, ...
(Date:12/20/2016)... , Dec. 20, 2016 The ... sharing, rental and leasing is stoking significant interest ... radio frequency technology, Bluetooth low energy (BLE), biometrics ... as the next wave of wireless technologies in ... access system to advanced access systems opens the ...
(Date:12/19/2016)... TORONTO , 19 de diciembre de 2016 /PRNewswire/ ... que permitirá el desarrollo acelerado de MSC-1, un anticuerpo humanizado que ... de tumor en 2017, con múltiples sitios previstos a lo largo ... ... en el factor inhibidor de leucemia (LIF), una citoquina pleiotrópica que ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... and HOUSTON , Jan. 19, ... today announced the formation of its Medical/Clinical Advisory ... and industry veterans who enhance the range and ... accelerates development of its novel prenatal diagnostic tests.  ... clinical and strategic guidance for the company,s product ...
(Date:1/19/2017)... CA (PRWEB) , ... January 19, 2017 , ... ... delivery of product vigilance software to leading biopharmaceutical and medical device manufacturers and ... is a fully 21 CFR Part 11-compliant email client designed to provide product ...
(Date:1/19/2017)... (PRWEB) , ... January 18, 2017 , ... ... National Institutes of Health (NIH) to update its Data Sharing Policy. Specifically, the ... element of grant applications subject to the existing policy. AMIA recommended that NIH ...
(Date:1/19/2017)... , Jan. 18, 2017 The ... reach USD 92.9 billion by 2025, according to ... Pharmaceutical industry has been adaptive of the function ... early as 2002. Among the services outsourced, clinical ... For instance, Johnson & Johnson was the first ...
Breaking Biology Technology:
Cached News: