HOME >> BIOLOGY >> NEWS
Alcohol Consumption, Resistance To Its Effects Related To Levels Of Neurotransmitter, Say UW Researchers

Science is still a long way from understanding why some people are more prone to alcoholism and alcohol abuse than others, but University of Washington researchers have discovered that concentrations of a neurotransmitter in the brains of mice are directly related to alcohol consumption and resistance to the sedative effects of alcohol.

Writing in tomorrow's issue of the journal Nature, the UW scientists report that genetically altered mice that do not produce the naturally occurring brain chemical or neurotransmitter called neuropeptide Y (NPY) drank significantly more alcohol and were less affected by its sedative, or sleep-inducing, effects than normal mice. In addition, genetically engineered mice that produce abnormally high levels of NPY drank less alcohol than normal mice and were highly prone to succumb to its sedative effects.

"This is the first direct demonstration that there are altered levels of alcohol consumption if you change the amount of NPY present in the brains of rodents," said Todd Thiele, who headed the UW team along with Richard Palmiter. "Alcohol consumption and resistance are inversely proportional to concentrations of NPY in the brain. Together, these data indicate that in rodents there is a relationship between NPY levels and the willingness to voluntarily consume alcohol."

The researchers cautioned that while their results with mice are convincing, further research is necessary to determine if there is a relationship between NPY and alcohol consumption and abuse in humans. They next plan to try to find the mechanism by which NPY in the brain modulates alcohol drinking.

"This study is important for two reasons," according to Dr. Enoch Gordis, director of the National Institute on Alcohol Abuse and Alcoholism. "It indicates that peptides related to appetite and anxiety are significant areas for study in alcohol research and that drugs designed to interact with components of the n
'"/>

Contact: Joel Schwarz
joels@u.washington.edu
206-543-2580
University of Washington
26-Nov-1998


Page: 1 2

Related biology news :

1. Alcohol-use and depression among pregnant and postpartum women
2. Alcoholism risk linked to gene involved in brain chemistry
3. Alcohol consumption can damage hearing
4. Alcohol-dependence gene identified
5. Alcohol exposure in pre- and early post-natal stages may cause insulin resistance
6. Alcoholics with antisocial personality disorder have blunted emotional reactivity
7. Alcohols pharmacological properties, not smell or taste, reinforce its effects
8. Alcohol abuse may increase susceptibility to HIV infection
9. Alcohol researchers relate a genetic factor to anxiety in women
10. Alcohol researchers identify a genetic basis of pain response
11. Alcohols effects on testosterone

Post Your Comments:
(Date:8/18/2015)... Research and Markets ( http://www.researchandmarkets.com/research/9dmm6l/global_biometric ) ... Biometric Authentication & Identification Market: Focus On Modality, ... report to their offering. ... is expected to grow at an estimated CAGR ... over $25 billion (approximately) by 2020 as per ...
(Date:8/12/2015)... , Aug. 12, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that four of its ... solution, have officially been named FIDO Certified™ by ... of the certification, Synaptics, Natural ID™ fingerprint solutions ... Authentication Framework (UAF) standard and are interoperable among ...
(Date:8/6/2015)... Germany , August 6, 2015 /PRNewswire/ ... SensoMotoric Instruments (SMI) shows the world,s first ... based on Epson,s Moverio BT-200 see-through head mounted display ... new solution, unprecedented quality and efficiency is brought to ... displays. For the first time, professionals and researchers can ...
Breaking Biology News(10 mins):Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3
(Date:9/4/2015)... ... September 04, 2015 , ... ... bioprinter, the BioBot 1, at the 2015 TERMIS World Congress in Boston. The ... and biomedical engineering institutions around the world. The printer is revolutionary for its ...
(Date:9/3/2015)... Sept. 3, 2015  Guardant Health®, the leader ... highlighting the performance and clinical utility of Guardant360® ... oral and poster presentations at the International Association ... Conference on Lung Cancer. These abstracts were submitted ... California, Davis; the University of Chicago; Sarah Cannon ...
(Date:9/3/2015)... India , September 3, 2015 ... Instruments Market by System (LC (HPLC, UHPLC, Flash), GC, ... Phase Columns, Syringe Filters, Vials) - Analysis & Global ... Market is expected to reach around 9.223 Billion by ... CAGR of 5.5%. Browse 141 tables and ...
(Date:9/2/2015)... Bermuda , Sept. 2, 2015 Axovant Sciences ... the treatment of dementia, today announced upcoming presentations at three ... PM at the Baird 2015 Healthcare Conference in ... , Thursday, September 10 at 2:00 PM at the ... at the Millennium Broadway Hotel & Conference Center , ...
Breaking Biology Technology:BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 2BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 3BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 4Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 2Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 3Leading Cancer Centers to Present Clinical Utility Data For Guardant360 At IASLC's 16th World Conference on Lung Cancer in Denver Sept. 6-9 4Chromatography Instruments Market Worth $ 9.223 Billion by 2020 2Chromatography Instruments Market Worth $ 9.223 Billion by 2020 3Chromatography Instruments Market Worth $ 9.223 Billion by 2020 4Axovant Sciences To Present At Upcoming Investor Conferences 2Axovant Sciences To Present At Upcoming Investor Conferences 3
Cached News: