HOME >> BIOLOGY >> NEWS
Alcohol Consumption, Resistance To Its Effects Related To Levels Of Neurotransmitter, Say UW Researchers

Science is still a long way from understanding why some people are more prone to alcoholism and alcohol abuse than others, but University of Washington researchers have discovered that concentrations of a neurotransmitter in the brains of mice are directly related to alcohol consumption and resistance to the sedative effects of alcohol.

Writing in tomorrow's issue of the journal Nature, the UW scientists report that genetically altered mice that do not produce the naturally occurring brain chemical or neurotransmitter called neuropeptide Y (NPY) drank significantly more alcohol and were less affected by its sedative, or sleep-inducing, effects than normal mice. In addition, genetically engineered mice that produce abnormally high levels of NPY drank less alcohol than normal mice and were highly prone to succumb to its sedative effects.

"This is the first direct demonstration that there are altered levels of alcohol consumption if you change the amount of NPY present in the brains of rodents," said Todd Thiele, who headed the UW team along with Richard Palmiter. "Alcohol consumption and resistance are inversely proportional to concentrations of NPY in the brain. Together, these data indicate that in rodents there is a relationship between NPY levels and the willingness to voluntarily consume alcohol."

The researchers cautioned that while their results with mice are convincing, further research is necessary to determine if there is a relationship between NPY and alcohol consumption and abuse in humans. They next plan to try to find the mechanism by which NPY in the brain modulates alcohol drinking.

"This study is important for two reasons," according to Dr. Enoch Gordis, director of the National Institute on Alcohol Abuse and Alcoholism. "It indicates that peptides related to appetite and anxiety are significant areas for study in alcohol research and that drugs designed to interact with components of the n
'"/>

Contact: Joel Schwarz
joels@u.washington.edu
206-543-2580
University of Washington
26-Nov-1998


Page: 1 2

Related biology news :

1. Alcohol-use and depression among pregnant and postpartum women
2. Alcoholism risk linked to gene involved in brain chemistry
3. Alcohol consumption can damage hearing
4. Alcohol-dependence gene identified
5. Alcohol exposure in pre- and early post-natal stages may cause insulin resistance
6. Alcoholics with antisocial personality disorder have blunted emotional reactivity
7. Alcohols pharmacological properties, not smell or taste, reinforce its effects
8. Alcohol abuse may increase susceptibility to HIV infection
9. Alcohol researchers relate a genetic factor to anxiety in women
10. Alcohol researchers identify a genetic basis of pain response
11. Alcohols effects on testosterone

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/12/2019)... ... November 12, 2019 , ... ... from nonprofit U.S. universities and research institutions for its Instrumentation Grant for ... up to $1.2 million per site for the acquisition of instrumentation, development and ...
(Date:11/7/2019)... (PRWEB) , ... November 07, 2019 , ... R3 Stem ... 50% off through the rest of 2019. The code to use during checkout is ... well. , R3 is the nation’s leader in regenerative therapies with over 12,000 successful ...
(Date:11/5/2019)... ... November 05, 2019 , ... Dr. Lauren Kopp ... dentistry to Seattle, WA, including porcelain veneers , smile makeovers, dental implants, ... University of Washington, Dr. Kopp is passionate about serving her Seattle community with ...
Breaking Biology News(10 mins):
(Date:11/5/2019)... ... November 05, 2019 , ... Focal Healthcare ... Mark for its Fusion Bx 2.0 prostate fusion biopsy solution. By combining information ... Bx 2.0 will give urologists across Europe the ability to perform targeted transrectal ...
(Date:11/2/2019)... ... 2019 , ... A clinical trial usually involves many different ... principal investigators, supply chain managers, manufacturers, IRT, CRAs and so on. Lack of ... data, potentially leading to patient risk. , By having a single source of ...
(Date:11/2/2019)... (PRWEB) , ... October 31, 2019 , ... ... released by pharma artificial intelligence pioneer tellic. drug360 brings tellic’s expertise in ... new tool allows researchers to quickly uncover relationships between genes, diseases, variants, phenotypes, ...
(Date:10/30/2019)... ... October 30, 2019 , ... Western University of ... innovation and technology play in educating the next generation of health care providers. ... and presentations by WesternU administrators and representatives of companies working with the University ...
Breaking Biology Technology:
Cached News: