Alcohol and the human fetal brain

  • The first step in the metabolism of alcohol is its conversion to acetaldehyde (AcHO).
  • AcHO is a highly reactive and toxic chemical that can damage the cells of all living things.
  • In adults, AcHO is blocked from entering the brain.
  • The prenatal brain may metabolize alcohol differently than the adult brain.
  • Researchers found an unexpectedly high and rapid accumulation of AcHO in developing brain tissue.

In an effort to understand the sensitivity of the human prenatal brain to alcohol, scientists are engaging in a delicate area of research. In a study published in the September issue of Alcoholism: Clinical & Experimental Research, scientists compared the metabolism of alcohol in prenatal human brain and liver tissue with the metabolism in both prenatal and adult rodent brain and liver tissue. More specifically, researchers closely examined the conversion of alcohol to acetaldehyde (AcHO) -- a highly reactive and toxic alcohol metabolite -- in the human prenatal brain.

"The public gets outraged when they hear about crack babies," observed Thomas R. Hinds, research associate professor at the University of Washington, "but are relatively blas about children born with alcohol-induced birth defects. The more that we as scientists can substantiate the links between prenatal alcohol exposure and Fetal Alcohol Effects and the more severe Fetal Alcohol Syndrome, the more likely the public will accept it as fact."

The first step in the metabolism of alcohol is its conversion to acetaldehyde (AcHO). AcHO belongs to a class of compounds called aldehydes (such as formaldehyde, a disinfectant and preservative), and is well known as a highly reactive and toxic chemical that can damage the cells of all living things. Normally, the liver is responsible for detoxifying the body from alcohol; alcohol is converted to AcHO in the liver, which is then rapidly metabolized to acetate, which is then further metabolized by tissues outs

Contact: Mont R. Juchau, Ph.D.
Alcoholism: Clinical & Experimental Research

Page: 1 2 3 4

Related biology news :

1. Alcohol-use and depression among pregnant and postpartum women
2. Alcoholism risk linked to gene involved in brain chemistry
3. Alcohol consumption can damage hearing
4. Alcohol-dependence gene identified
5. Alcohol exposure in pre- and early post-natal stages may cause insulin resistance
6. Alcoholics with antisocial personality disorder have blunted emotional reactivity
7. Alcohols pharmacological properties, not smell or taste, reinforce its effects
8. Alcohol abuse may increase susceptibility to HIV infection
9. Alcohol researchers relate a genetic factor to anxiety in women
10. Alcohol researchers identify a genetic basis of pain response
11. Alcohols effects on testosterone

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: